NEDD1 NEDD1 gamma-tubulin ring complex targeting factor [Homo sapiens (human)] - Gene

Summary

Official Symbol: NEDD1provided by HGNC
Official Full Name: NEDD1 gamma-tubulin ring complex targeting factorprovided by HGNC
Primary source: HGNC:HGNC:7723
See related: Ensembl:ENSG00000139350 MIM:600372; AllianceGenome:HGNC:7723
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GCP-WD; TUBGCP7
Summary: Predicted to enable gamma-tubulin binding activity. Predicted to be involved in microtubule nucleation and mitotic cell cycle. Located in centrosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis (RPKM 11.1), lymph node (RPKM 7.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q23.1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (96907257..96953780)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (96881012..96927469)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (97301035..97347558)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis.
Title: NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis.
PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations.
Title: PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations.
Authors show here that the expression of a NEDD1 isoform mimicking phosphorylation by Aurora A is sufficient to restore microtubule nucleation in the midzone under conditions of Aurora A inhibition.
Title: Microtubule nucleation during central spindle assembly requires NEDD1 phosphorylation on serine 405 by Aurora A.
One important function of Aurora A in mitotic cells is to promote microtubule nucleation around the chromatin by phosphorylating NEDD1, and thereby to promote functional spindle assembly.
Title: The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function.
The mice treated with small interfering (si) RNA targeting NEDD1 by the atelocollagen-mediated delivery system showed a significantly prolonged survival in a xenograft model of human gastric cancer.
Title: Intraperitoneal delivery of a small interfering RNA targeting NEDD1 prolongs the survival of scirrhous gastric cancer model mice.
Data suggest that the NEDD1/gamma-tubulin interaction is finely tuned by multiple phosphorylation events in the S557-S574 region and is critical for spindle assembly.
Title: Novel NEDD1 phosphorylation sites regulate γ-tubulin binding and mitotic spindle assembly.
Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells.
Title: Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.
a direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome
Title: A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome.
Data suggest that sequential phosphorylation of Nedd1 by Cdk1 and Plk1 plays a role in targeting gamma tubulin ring complex to the centrosome by promoting the interaction of Nedd1 with the gammaTuRC component gamma-tubulin, during mitosis.
Title: Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.
Data propose NEDD1 may be a promising target for controlling cell proliferation, in particular if targeted in combination with Plk1 inhibitors.
Title: The centrosome protein NEDD1 as a potential pharmacological target to induce cell cycle arrest.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants on 1p13.2 associate with risk of autism. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants associated with breast size also influence breast cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93549 (e-PCR)
- UniSTS:90405

PMC310794P11 (e-PCR)
- UniSTS:272699

NEDD1_8133 (e-PCR)
- UniSTS:467798

RH79078 (e-PCR)
- UniSTS:66243

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables gamma-tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in fibrillar center	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein NEDD1

Names: NEDD-1; neural precursor cell expressed developmentally down-regulated protein 1; neural precursor cell expressed, developmentally down-regulated 1; tubulin gamma complex associated protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135175.2 → NP_001128647.1 protein NEDD1 isoform a

See identical proteins and their annotated locations for NP_001128647.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AA236927, AC007564, AC013417, AK290058, AL832466, BC027605

Consensus CDS

CCDS44955.1

UniProtKB/TrEMBL

A8K1Z3

Related

ENSP00000451211.1, ENST00000557644.5

Conserved Domains (3) summary

COG2319
Location:10 → 285

WD40; WD40 repeat [General function prediction only]

cd00200
Location:31 → 306

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:88 → 124

7WD40; WD40 repeat [structural motif]
NM_001135176.2 → NP_001128648.1 protein NEDD1 isoform b

See identical proteins and their annotated locations for NP_001128648.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1, resulting in an isoform (b) that has a shorter N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AA236927, AC013417, AK290058, AK315821, AL832466

Consensus CDS

CCDS9063.1

UniProtKB/Swiss-Prot

B0AZN0, B4E145, G3V3F1, Q8NA30, Q8NHV4

UniProtKB/TrEMBL

A8K1Z3

Related

ENSP00000404978.2, ENST00000429527.6

Conserved Domains (2) summary

cd00200
Location:24 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:81 → 117

7WD40; WD40 repeat [structural motif]
NM_001135177.2 → NP_001128649.1 protein NEDD1 isoform c

See identical proteins and their annotated locations for NP_001128649.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1, resulting in an isoform (c) that has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AA236927, AC013417, AK290058, AK303656, AL832466

Consensus CDS

CCDS44956.1

UniProtKB/TrEMBL

A8K1Z3

Related

ENSP00000411307.2, ENST00000411739.6

Conserved Domains (3) summary

COG2319
Location:2 → 220

WD40; WD40 repeat [General function prediction only]

cd00200
Location:2 → 210

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:34 → 71

7WD40; WD40 repeat [structural motif]
NM_152905.4 → NP_690869.1 protein NEDD1 isoform b

See identical proteins and their annotated locations for NP_690869.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1, resulting in an isoform (b) that has a shorter N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AA236927, AC013417, AK290058, AK315821, AL832466

Consensus CDS

CCDS9063.1

UniProtKB/Swiss-Prot

B0AZN0, B4E145, G3V3F1, Q8NA30, Q8NHV4

UniProtKB/TrEMBL

A8K1Z3

Related

ENSP00000266742.5, ENST00000266742.9

Conserved Domains (2) summary

cd00200
Location:24 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:81 → 117

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

96907257..96953780

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005268644.3 → XP_005268701.1 protein NEDD1 isoform X1

See identical proteins and their annotated locations for XP_005268701.1

UniProtKB/TrEMBL

A8K1Z3

Conserved Domains (3) summary

COG2319
Location:10 → 285

WD40; WD40 repeat [General function prediction only]

cd00200
Location:31 → 306

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:88 → 124

7WD40; WD40 repeat [structural motif]
XM_006719237.5 → XP_006719300.1 protein NEDD1 isoform X2

See identical proteins and their annotated locations for XP_006719300.1

UniProtKB/TrEMBL

A8K1Z3

Conserved Domains (3) summary

COG2319
Location:2 → 220

WD40; WD40 repeat [General function prediction only]

cd00200
Location:2 → 210

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:34 → 71

7WD40; WD40 repeat [structural motif]
XM_011537903.4 → XP_011536205.1 protein NEDD1 isoform X2

See identical proteins and their annotated locations for XP_011536205.1

UniProtKB/TrEMBL

A8K1Z3

Related

ENSP00000407964.2, ENST00000457368.2

Conserved Domains (3) summary

COG2319
Location:2 → 220

WD40; WD40 repeat [General function prediction only]

cd00200
Location:2 → 210

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:34 → 71

7WD40; WD40 repeat [structural motif]
XM_047428288.1 → XP_047284244.1 protein NEDD1 isoform X3
XM_047428289.1 → XP_047284245.1 protein NEDD1 isoform X4
XM_047428290.1 → XP_047284246.1 protein NEDD1 isoform X5