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    ADGRG6 adhesion G protein-coupled receptor G6 [ Homo sapiens (human) ]

    Gene ID: 57211, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ADGRG6provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor G6provided by HGNC
    Primary source
    HGNC:HGNC:13841
    See related
    Ensembl:ENSG00000112414 MIM:612243; AllianceGenome:HGNC:13841
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APG1; DREG; VIGR; LCCS9; PR126; GPR126; PS1TP2
    Summary
    This gene, which is upregulated in human umbilical vein endothelial cells, encodes a G protein-coupled receptor. Variations in this gene can affect a person's stature. Multiple transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Mar 2009]
    Expression
    Broad expression in placenta (RPKM 17.7), liver (RPKM 15.5) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADGRG6 in Genome Data Viewer
    Location:
    6q24.2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (142302007..142446261)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (143494208..143638629)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (142623144..142767398)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1984 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:142468581-142469101 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:142476776-142477403 Neighboring gene Sharpr-MPRA regulatory region 15423 Neighboring gene vesicle trafficking 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:142596514-142597713 Neighboring gene long intergenic non-protein coding RNA 2919 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17614 Neighboring gene Sharpr-MPRA regulatory region 14737 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:142695388-142695989 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:142695947-142697146 Neighboring gene Sharpr-MPRA regulatory regions 3748 and 6738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:142872203-142872704 Neighboring gene uncharacterized LOC153910 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:142898477-142899003 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:142968516-142969102 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:142969103-142969689 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:142970487-142971223 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:142992915-142994114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25178 Neighboring gene MPRA-validated peak6174 silencer Neighboring gene Sharpr-MPRA regulatory region 15083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25179 Neighboring gene HIVEP zinc finger 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25181 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:143167126-143167819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25184 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:143206090-143207289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25185 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:143233161-143234017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17615 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17616 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17620

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. Werder RB, et al. Am J Hum Genet, 2023 Oct 5. PMID 37734371, Free PMC Article
    2. Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms. Agnati LF, et al. J Recept Signal Transduct Res, 2011 Oct. PMID 21929287
    3. [Protein expression and function of gene 2 transregulated by hepatitis B virus pre-s1 protein and its cloning]. Wang DQ, et al. Zhonghua Gan Zang Bing Za Zhi, 2008 Feb. PMID 18304421
    4. NMR structure of a human homologous methuselah gene receptor peptide. Kikkou T, et al. Biochem Biophys Res Commun, 2007 Jan 5. PMID 17109822
    5. Association of GPR126 gene polymorphism with adolescent idiopathic scoliosis in Chinese populations. Xu JF, et al. Genomics, 2015 Feb. PMID 25479386

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys.
      Title: Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys.
    2. Analysis of GPR126 polymorphisms and their relationship with scoliosis in Marfan syndrome and Marfan-like syndrome in Mexican patients.
      Title: Analysis of GPR126 polymorphisms and their relationship with scoliosis in Marfan syndrome and Marfan-like syndrome in Mexican patients.
    3. The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells.
      Title: The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells.
    4. Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney.
      Title: Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney.
    5. Noncoding SNP at rs1663689 represses ADGRG6 via interchromosomal interaction and reduces lung cancer progression.
      Title: Noncoding SNP at rs1663689 represses ADGRG6 via interchromosomal interaction and reduces lung cancer progression.
    6. Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.
      Title: Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.
    7. Genomic characterization of the adolescent idiopathic scoliosis-associated transcriptome and regulome.
      Title: Genomic characterization of the adolescent idiopathic scoliosis-associated transcriptome and regulome.
    8. Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells.
      Title: Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells.
    9. GPR126 regulates colorectal cancer cell proliferation by mediating HDAC2 and GLI2 expression.
      Title: GPR126 regulates colorectal cancer cell proliferation by mediating HDAC2 and GLI2 expression.
    10. A synthetic method to assay adhesion-family G-protein coupled receptors. Determination of the G-protein coupling profile of ADGRG6(GPR126).
      Title: A synthetic method to assay adhesion-family G-protein coupled receptors. Determination of the G-protein coupling profile of ADGRG6(GPR126).
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Lethal congenital contracture syndrome 9
    MedGen: C4225303 OMIM: 616503 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis.
    EBI GWAS Catalog
    Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
    EBI GWAS Catalog
    Genome-wide association study of height and body mass index in Australian twin families.
    EBI GWAS Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Identification of ten loci associated with height highlights new biological pathways in human growth.
    EBI GWAS Catalog
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog
    Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog
    Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables collagen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables endopeptidase activity TAS
    Traceable Author Statement
    more info
    		  
    enables extracellular matrix binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables laminin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables laminin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in Schwann cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cAMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heart trabecula formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myelination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myelination in peripheral nervous system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myelination in peripheral nervous system ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor G6
    Names
    G-protein coupled receptor 126
    HBV PreS1-transactivated protein 2
    developmentally regulated G-protein-coupled receptor
    vascular-inducible G protein-coupled receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011839.2 RefSeqGene

      Range
      5002..149256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032394.3 → NP_001027566.2  adhesion G-protein coupled receptor G6 isoform alpha 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a2) lacks an alternate in-frame exon and contains an alternate coding exon in the 3' end of the transcript compared to variant b1, that causes a frameshift. The resulting isoform (alpha 2) is shorter and has a distinct C-terminus compared to isoform beta 1.
      Source sequence(s)
      AL033377, AL360007
      Consensus CDS
      CCDS47491.1
      Related
      ENSP00000296932.8, ENST00000296932.13
      Conserved Domains (5) summary
      cd00041
      Location:43 → 146
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam01825
      Location:773 → 818
      GPS; GPCR proteolysis site, GPS, motif
      cd14964
      Location:835 → 860
      7tm_GPCRs; TM helix 1 [structural motif]
      cl22861
      Location:153 → 337
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cl28897
      Location:833 → 1101
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001032395.3 → NP_001027567.2  adhesion G-protein coupled receptor G6 isoform beta 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b2) lacks an alternate in-frame exon compared to variant b1. The resulting isoform (beta 2) has the same N- and C-termini but is shorter compared to isoform beta 1.
      Source sequence(s)
      AL033377, AL360007
      Consensus CDS
      CCDS55064.1
      Related
      ENSP00000356580.2, ENST00000367608.6
      Conserved Domains (4) summary
      cd00041
      Location:43 → 146
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd15996
      Location:833 → 1101
      7tmB2_GPR126; orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:773 → 818
      GPS; GPCR proteolysis site, GPS, motif
      cl22861
      Location:153 → 337
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    3. NM_020455.6 → NP_065188.5  adhesion G-protein coupled receptor G6 isoform alpha 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a1) contains an alternate coding exon in the 3' end of the transcript compared to variant b1, that causes a frameshift. The resulting isoform (alpha 1) is shorter and has a distinct C-terminus compared to isoform beta 1.
      Source sequence(s)
      AL033377, AL360007
      Consensus CDS
      CCDS47490.1
      UniProtKB/Swiss-Prot
      Q5TGN7, Q6DHZ4, Q6F3F5, Q6F3F6, Q6F3F7, Q6F3F8, Q6MZU7, Q86SQ4, Q8IXA4, Q8NC14, Q96JW0
      Related
      ENSP00000230173.6, ENST00000230173.10
      Conserved Domains (4) summary
      cd00041
      Location:43 → 146
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd15996
      Location:861 → 1129
      7tmB2_GPR126; orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:801 → 846
      GPS; GPCR proteolysis site, GPS, motif
      cl22861
      Location:153 → 337
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    4. NM_198569.3 → NP_940971.2  adhesion G-protein coupled receptor G6 isoform beta 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b1) encodes the longest isoform (beta 1).
      Source sequence(s)
      AB183548, AL033377, AL080079
      Consensus CDS
      CCDS47489.1
      Related
      ENSP00000356581.3, ENST00000367609.8
      Conserved Domains (4) summary
      cd00041
      Location:43 → 146
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd15996
      Location:861 → 1129
      7tmB2_GPR126; orphan adhesion receptor GPR126, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:801 → 846
      GPS; GPCR proteolysis site, GPS, motif
      cl22861
      Location:153 → 337
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      142302007..142446261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005267061.4 → XP_005267118.1  adhesion G-protein coupled receptor G6 isoform X4

      Conserved Domains (4) summary
      cd00041
      Location:44 → 147
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam01825
      Location:802 → 847
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:864 → 1111
      7tm_4; Olfactory receptor
      cl22861
      Location:154 → 338
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    2. XM_006715516.3 → XP_006715579.1  adhesion G-protein coupled receptor G6 isoform X1

      Conserved Domains (4) summary
      cd00041
      Location:44 → 147
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam01825
      Location:802 → 847
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:864 → 1111
      7tm_4; Olfactory receptor
      cl22861
      Location:154 → 338
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    3. XM_047419106.1 → XP_047275062.1  adhesion G-protein coupled receptor G6 isoform X9

    4. XM_006715518.3 → XP_006715581.1  adhesion G-protein coupled receptor G6 isoform X3

      Conserved Domains (4) summary
      cd00041
      Location:44 → 147
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam01825
      Location:774 → 819
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:836 → 1083
      7tm_4; Olfactory receptor
      cl22861
      Location:154 → 338
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    5. XM_017011085.2 → XP_016866574.1  adhesion G-protein coupled receptor G6 isoform X11

    6. XM_047419103.1 → XP_047275059.1  adhesion G-protein coupled receptor G6 isoform X6

    7. XM_011535964.2 → XP_011534266.1  adhesion G-protein coupled receptor G6 isoform X12

      Conserved Domains (4) summary
      cd00041
      Location:43 → 146
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam01825
      Location:801 → 846
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:863 → 1110
      7tm_4; Olfactory receptor
      cl22861
      Location:153 → 337
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    8. XM_047419107.1 → XP_047275063.1  adhesion G-protein coupled receptor G6 isoform X10

    9. XM_047419102.1 → XP_047275058.1  adhesion G-protein coupled receptor G6 isoform X5

    10. XM_047419105.1 → XP_047275061.1  adhesion G-protein coupled receptor G6 isoform X8

    11. XM_006715517.3 → XP_006715580.1  adhesion G-protein coupled receptor G6 isoform X2

      Conserved Domains (4) summary
      cd00041
      Location:42 → 145
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam01825
      Location:800 → 845
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:862 → 1109
      7tm_4; Olfactory receptor
      cl22861
      Location:152 → 336
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    12. XM_047419104.1 → XP_047275060.1  adhesion G-protein coupled receptor G6 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      143494208..143638629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355983.1 → XP_054211958.1  adhesion G-protein coupled receptor G6 isoform X4

    2. XM_054355980.1 → XP_054211955.1  adhesion G-protein coupled receptor G6 isoform X1

    3. XM_054355988.1 → XP_054211963.1  adhesion G-protein coupled receptor G6 isoform X9

    4. XM_054355982.1 → XP_054211957.1  adhesion G-protein coupled receptor G6 isoform X3

    5. XM_054355990.1 → XP_054211965.1  adhesion G-protein coupled receptor G6 isoform X11

    6. XM_054355985.1 → XP_054211960.1  adhesion G-protein coupled receptor G6 isoform X6

    7. XM_054355984.1 → XP_054211959.1  adhesion G-protein coupled receptor G6 isoform X5

    8. XM_054355981.1 → XP_054211956.1  adhesion G-protein coupled receptor G6 isoform X2

    9. XM_054355989.1 → XP_054211964.1  adhesion G-protein coupled receptor G6 isoform X10

    10. XM_054355987.1 → XP_054211962.1  adhesion G-protein coupled receptor G6 isoform X8

    11. XM_054355986.1 → XP_054211961.1  adhesion G-protein coupled receptor G6 isoform X7

    12. XM_054355991.1 → XP_054211966.1  adhesion G-protein coupled receptor G6 isoform X12

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86SQ4.3 GenPept UniProtKB/Swiss-Prot:Q86SQ4

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