ZFP36 ZFP36 ring finger protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZFP36provided by HGNC
Official Full Name: ZFP36 ring finger proteinprovided by HGNC
Primary source: HGNC:HGNC:12862
See related: Ensembl:ENSG00000128016 MIM:190700; AllianceGenome:HGNC:12862
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TTP; G0S24; GOS24; TIS11; NUP475; zfp-36; RNF162A
Summary: Enables several functions, including 14-3-3 protein binding activity; heat shock protein binding activity; and mRNA 3'-UTR AU-rich region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to epidermal growth factor stimulus; and regulation of gene expression. Acts upstream of or within mRNA catabolic process. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleus. Part of ribonucleoprotein complex. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in gall bladder (RPKM 274.6), bone marrow (RPKM 248.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (39406847..39409407)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (42211127..42213687)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (39897487..39900047)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Persistent infection with Porphyromonas gingivalis increases the tumorigenic potential of human immortalised oral epithelial cells through ZFP36 inhibition.
Title: Persistent infection with Porphyromonas gingivalis increases the tumorigenic potential of human immortalised oral epithelial cells through ZFP36 inhibition.
ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFNbeta/lambda expression and promotes ZIKV persistence.
Title: ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFNβ/λ expression and promotes ZIKV persistence.
ZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC.
Title: ZFP36 loss-mediated BARX1 stabilization promotes malignant phenotypes by transactivating master oncogenes in NSCLC.
Silencing lncRNA CDKN2B-AS1 Alleviates Childhood Asthma Progression Through Inhibiting ZFP36 Promoter Methylation and Promoting NR4A1 Expression.
Title: Silencing lncRNA CDKN2B-AS1 Alleviates Childhood Asthma Progression Through Inhibiting ZFP36 Promoter Methylation and Promoting NR4A1 Expression.
Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with Schizophrenia.
Title: Assessing the expression of two post-transcriptional BDNF regulators, TTP and miR-16 in the peripheral blood of patients with Schizophrenia.
Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA.
Title: Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA.
Identification of ISG15 and ZFP36 as novel hypoxia- and immune-related gene signatures contributing to a new perspective for the treatment of prostate cancer by bioinformatics and experimental verification.
Title: Identification of ISG15 and ZFP36 as novel hypoxia- and immune-related gene signatures contributing to a new perspective for the treatment of prostate cancer by bioinformatics and experimental verification.
Tristetraprolin Prevents Gastric Metaplasia in Mice by Suppressing Pathogenic Inflammation.
Title: Tristetraprolin Prevents Gastric Metaplasia in Mice by Suppressing Pathogenic Inflammation.
TTP-mediated regulation of mRNA stability in immune cells contributes to adaptive immunity, immune tolerance and clinical applications.
Title: TTP-mediated regulation of mRNA stability in immune cells contributes to adaptive immunity, immune tolerance and clinical applications.
ZFP36 promotes VDR mRNA degradation to facilitate cell death in oral and colonic epithelial cells.
Title: ZFP36 promotes VDR mRNA degradation to facilitate cell death in oral and colonic epithelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (181)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of tristetraprolin	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19S633E (e-PCR)
- UniSTS:150556

STS-H28008 (e-PCR)
- UniSTS:2088

STS-M92843 (e-PCR)
- UniSTS:19771

RH81038 (e-PCR)
- UniSTS:83592

RH80286 (e-PCR)
- UniSTS:90029

PMC321570P3 (e-PCR)
- UniSTS:273117

ZFP36 (e-PCR)
- UniSTS:279271

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables C-C chemokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	HDA more info	PubMed
enables RNA polymerase binding	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables heat shock protein binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA 3'-UTR AU-rich region binding	TAS Traceable Author Statement more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in 3'-UTR-mediated mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in 3'-UTR-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to epidermal growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in hematopoietic stem cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA-mediated gene silencing by inhibition of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of erythrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of hematopoietic stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-2 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of polynucleotide adenylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of miRNA-mediated gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of keratinocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA stability	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mRNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in response to wounding	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	ISS Inferred from Sequence or Structural Similarity more info
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
NOT part_of exosome (RNase complex)	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mRNA decay activator protein ZFP36

Names: G0/G1 switch regulatory protein 24; growth factor-inducible nuclear protein NUP475; tristetraprolin; tristetraproline; zinc finger protein 36 homolog; zinc finger protein 36, C3H type, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003407.5 → NP_003398.3 mRNA decay activator protein ZFP36

Status: VALIDATED

Source sequence(s)

AC011500, M92843

Consensus CDS

CCDS12534.3

UniProtKB/Swiss-Prot

B2RA54, P26651

Related

ENSP00000469647.2, ENST00000597629.3

Conserved Domains (1) summary

cl11592
Location:104 → 200

zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)