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    ZNF611 zinc finger protein 611 [ Homo sapiens (human) ]

    Gene ID: 81856, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZNF611provided by HGNC
    Official Full Name
    zinc finger protein 611provided by HGNC
    Primary source
    HGNC:HGNC:28766
    See related
    Ensembl:ENSG00000213020 AllianceGenome:HGNC:28766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 2.4), thyroid (RPKM 2.3) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF611 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52702813..52735044, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55787259..55819509, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53206066..53238297, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 677-like Neighboring gene zinc finger protein 83 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53140536-53141054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53141055-53141572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10996 Neighboring gene Sharpr-MPRA regulatory region 1800 Neighboring gene Zinc finger protein LOC122539214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53167404-53167904 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53171845-53172346 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:53172853-53174052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53177263-53177762 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53179336-53179900 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53179901-53180465 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53192883-53193418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10997 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53196613-53197148 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53199383-53200194 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53201006-53201816 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53201817-53202627 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:53219681-53220253 Neighboring gene uncharacterized LOC124904760 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53238285-53239270 Neighboring gene uncharacterized LOC105372452 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:53259364-53260079 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:53263091-53263641 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53285228-53285408 Neighboring gene zinc finger protein 600 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:53287129-53287305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53289004-53289862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53289863-53290720 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:53293023-53293553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:53294085-53294614 Neighboring gene zinc finger protein 28 Neighboring gene PABPN1 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    2. Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. Wang P, et al. J Clin Invest, 2019 Jul 25. PMID 31343991, Free PMC Article
    3. Human transcription factor protein interaction networks. Göös H, et al. Nat Commun, 2022 Feb 9. PMID 35140242, Free PMC Article
    4. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
    5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC5384

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 611

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161499.2 → NP_001154971.1  zinc finger protein 611 isoform a

      See identical proteins and their annotated locations for NP_001154971.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AC022150, BC028590, DA226106, DA245006, DA726181
      Consensus CDS
      CCDS12855.1
      UniProtKB/Swiss-Prot
      B3KRD5, Q69YG9, Q8N823
      Related
      ENSP00000498713.1, ENST00000652185.1
      Conserved Domains (5) summary
      smart00349
      Location:24 → 60
      KRAB; krueppel associated box
      COG5048
      Location:256 → 698
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:540 → 560
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:24 → 60
      KRAB; KRAB box
      pfam13465
      Location:665 → 689
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001161500.2 → NP_001154972.1  zinc finger protein 611 isoform a

      See identical proteins and their annotated locations for NP_001154972.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AC022150, BC028590, DB122407
      Consensus CDS
      CCDS12855.1
      UniProtKB/Swiss-Prot
      B3KRD5, Q69YG9, Q8N823
      Related
      ENSP00000439211.1, ENST00000540744.5
      Conserved Domains (5) summary
      smart00349
      Location:24 → 60
      KRAB; krueppel associated box
      COG5048
      Location:256 → 698
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:540 → 560
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:24 → 60
      KRAB; KRAB box
      pfam13465
      Location:665 → 689
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001161501.1 → NP_001154973.1  zinc finger protein 611 isoform b

      See identical proteins and their annotated locations for NP_001154973.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC022150, BC028590, DA225124
      Consensus CDS
      CCDS54312.1
      UniProtKB/Swiss-Prot
      Q8N823
      Related
      ENSP00000443505.1, ENST00000453741.6
      Conserved Domains (3) summary
      COG5048
      Location:187 → 629
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:471 → 491
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:596 → 620
      zf-H2C2_2; Zinc-finger double domain

    4. NM_030972.3 → NP_112234.3  zinc finger protein 611 isoform a

      See identical proteins and their annotated locations for NP_112234.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC022150, AK097434, BC028590, BC143996
      Consensus CDS
      CCDS12855.1
      UniProtKB/Swiss-Prot
      B3KRD5, Q69YG9, Q8N823
      Related
      ENSP00000322427.1, ENST00000319783.5
      Conserved Domains (5) summary
      smart00349
      Location:24 → 60
      KRAB; krueppel associated box
      COG5048
      Location:256 → 698
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:540 → 560
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:24 → 60
      KRAB; KRAB box
      pfam13465
      Location:665 → 689
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      52702813..52735044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      55787259..55819509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N823.2 GenPept UniProtKB/Swiss-Prot:Q8N823

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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