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    ERBIN erbb2 interacting protein [ Homo sapiens (human) ]

    Gene ID: 55914, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ERBINprovided by HGNC
    Official Full Name
    erbb2 interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:15842
    See related
    Ensembl:ENSG00000112851 MIM:606944; AllianceGenome:HGNC:15842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAP2; ERBB2IP; HEL-S-78
    Summary
    This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in small intestine (RPKM 17.6), lymph node (RPKM 17.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ERBIN in Genome Data Viewer
    Location:
    5q12.3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (65926575..66082546)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (66748417..66903759)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (65222403..65378374)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22609 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:65015266-65015462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16057 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16058 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:65018623-65019444 Neighboring gene small glutamine rich tetratricopeptide repeat co-chaperone beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16059 Neighboring gene PRAME family member 17 pseudogene Neighboring gene neurolysin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16060 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:65220503-65221127 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:65221752-65222376 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22612 Neighboring gene LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene Neighboring gene small nucleolar RNA SNORA76 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22613 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:65280169-65280787 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:65283311-65283508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22614 Neighboring gene uncharacterized LOC124900987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22617 Neighboring gene splicing regulatory glutamic acid and lysine rich protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Palmitoylation of ERBIN is required for its plasma membrane localization. Izawa I, et al. Genes Cells, 2008 Jul. PMID 18498353
    2. LAP2 is widely overexpressed in diverse digestive tract cancers and regulates motility of cancer cells. Kim HJ, et al. PLoS One, 2012. PMID 22745766, Free PMC Article
    3. Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain. Skelton NJ, et al. J Biol Chem, 2003 Feb 28. PMID 12446668
    4. Densin-180: revised membrane topology, domain structure and phosphorylation status. Thalhammer A, et al. J Neurochem, 2009 Apr. PMID 19187442, Free PMC Article
    5. Erbin: sorting out ErbB2 receptors or giving Ras a break? Kolch W. Sci STKE, 2003 Sep 9. PMID 12966186

    See all (151) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting Erbin-mitochondria axis in platelets/megakaryocytes promotes B cell-mediated antitumor immunity.
      Title: Targeting Erbin-mitochondria axis in platelets/megakaryocytes promotes B cell-mediated antitumor immunity.
    2. Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non-small cell lung carcinoma.
      Title: Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non-small cell lung carcinoma.
    3. Targeting Erbin in B cells for therapy of lung metastasis of colorectal cancer.
      Title: Targeting Erbin in B cells for therapy of lung metastasis of colorectal cancer.
    4. The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease.
      Title: The leucine-rich repeat signaling scaffolds Shoc2 and Erbin: cellular mechanism and role in disease.
    5. Findings show that ERBIN is required for Dsg1 requires to downregulate EGFR/Erk signaling and fully suppress invadopodia formation.
      Title: Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner.
    6. Erbin is mainly localized in endothelial cells in human umbilical veins and plays a critical role in endothelial cell migration and tubular formation via the Smad1/5 pathway.
      Title: Erbin plays a critical role in human umbilical vein endothelial cell migration and tubular structure formation via the Smad1/5 pathway.
    7. Erbin interacted with kinase suppressor of Ras 1 (KSR1) and displaced it from the RAF/MEK/ERK complex to prevent signal propagation..These findings establish the scaffold protein Erbin as a negative regulator of EMT and tumorigenesis in colorectal cancer through direct suppression of Akt and RAS/RAF signaling
      Title: Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer.
    8. Erbb2 interacting protein (ERBB2IP), a known target of miR-23c, was positively regulated by KTN1-AS1.
      Title: LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis.
    9. miR-23c inhibited cell proliferation and accelerated apoptosis by attenuating ERBB2IP.
      Title: miR-23c suppresses tumor growth of human hepatocellular carcinoma by attenuating ERBB2IP.
    10. Our data uncovered an important role of Erbin in regulating hepatocellular carcinoma (HCC) tumorigenesis through inactivating ERalpha-mediated tumor-suppressive signaling, suggesting a new strategy for tamoxifen therapy in HCC by targeting Erbin/ERalpha signaling axis.
      Title: Elevated expression of Erbin destabilizes ERα protein and promotes tumorigenesis in hepatocellular carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ErbB-2 class receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in basal protein localization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to tumor necrosis factor IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in intermediate filament cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of monocyte chemotactic protein-1 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to muramyl dipeptide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basal plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in basement membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in hemidesmosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic specialization IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    erbin
    Names
    densin-180-like protein
    epididymis secretory protein Li 78
    protein LAP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031822.2 RefSeqGene

      Range
      5022..160993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001006600.3 → NP_001006600.1  erbin isoform 7

      See identical proteins and their annotated locations for NP_001006600.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two consecutive exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.
      Source sequence(s)
      AB033051, AC025442, BC144075, BP199825, BP342103, BU145959, DA723889, DR000131, N67861
      Consensus CDS
      CCDS34172.1
      UniProtKB/TrEMBL
      A0A8V8TP09
      Related
      ENSP00000422015.1, ENST00000508515.2
      Conserved Domains (4) summary
      cd00116
      Location:48 → 209
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:1212 → 1297
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:24 → 47
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:322 → 380
      LRR_8; Leucine rich repeat

    2. NM_001253697.2 → NP_001240626.1  erbin isoform 1

      See identical proteins and their annotated locations for NP_001240626.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AB033051, AC025442, AF276423, BC144075, BP342103, DR000131, N67861
      Consensus CDS
      CCDS58953.1
      UniProtKB/Swiss-Prot
      A0AVR1, B4E3F1, B7ZLV9, E7EQW9, E9PCR8, Q1RMD0, Q86W38, Q96RT1, Q9NR18, Q9NW48, Q9ULJ5
      UniProtKB/TrEMBL
      Q1RMC9
      Related
      ENSP00000284037.4, ENST00000284037.10
      Conserved Domains (5) summary
      cd00116
      Location:48 → 209
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:1321 → 1407
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:24 → 47
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:368 → 411
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:322 → 380
      LRR_8; Leucine rich repeat

    3. NM_001253698.2 → NP_001240627.1  erbin isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AB033051, AC025442, AK304693, BC144075, BP342103, DR000131, N67861
      Consensus CDS
      CCDS58954.1
      UniProtKB/TrEMBL
      Q1RMC9
      Related
      ENSP00000370325.2, ENST00000380938.6
      Conserved Domains (5) summary
      cd00116
      Location:48 → 209
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:1280 → 1341
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:24 → 47
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:368 → 411
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:322 → 380
      LRR_8; Leucine rich repeat

    4. NM_001253699.2 → NP_001240628.1  erbin isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an exon and includes an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (8) is longer than isoform 1.
      Source sequence(s)
      AB033051, AC025442, BC144075, BP342103, DR000131, N67861
      Consensus CDS
      CCDS58952.1
      UniProtKB/TrEMBL
      Q1RMC9
      Related
      ENSP00000426632.1, ENST00000506030.6
      Conserved Domains (5) summary
      cd00116
      Location:48 → 209
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:1328 → 1414
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:24 → 47
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:368 → 411
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:322 → 380
      LRR_8; Leucine rich repeat

    5. NM_001253701.2 → NP_001240630.1  erbin isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses an alternate splice site and lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (9) is shorter than isoform 1.
      Source sequence(s)
      AB033051, AC025442, BC050692, BC144075, BP342103, DR000131, N67861
      Consensus CDS
      CCDS58951.1
      UniProtKB/TrEMBL
      Q1RMC9
      Related
      ENSP00000422766.1, ENST00000511297.5
      Conserved Domains (5) summary
      cd00116
      Location:48 → 209
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:1276 → 1362
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:24 → 47
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:368 → 411
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:322 → 380
      LRR_8; Leucine rich repeat

    6. NM_018695.4 → NP_061165.1  erbin isoform 2

      See identical proteins and their annotated locations for NP_061165.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB033051, AC025442, BC126464, BC144075, BP342103, DR000131, N67861
      Consensus CDS
      CCDS3990.1
      UniProtKB/TrEMBL
      Q1RMC9
      Related
      ENSP00000370330.2, ENST00000380943.6
      Conserved Domains (5) summary
      cd00116
      Location:48 → 209
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:1280 → 1366
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:24 → 47
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:368 → 411
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:322 → 380
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      65926575..66082546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417376.1 → XP_047273332.1  erbin isoform X1

    2. XM_047417378.1 → XP_047273334.1  erbin isoform X3

    3. XM_047417380.1 → XP_047273336.1  erbin isoform X5

      UniProtKB/Swiss-Prot
      A0AVR1, B4E3F1, B7ZLV9, E7EQW9, E9PCR8, Q1RMD0, Q86W38, Q96RT1, Q9NR18, Q9NW48, Q9ULJ5

    4. XM_047417382.1 → XP_047273338.1  erbin isoform X7

    5. XM_047417384.1 → XP_047273340.1  erbin isoform X9

    6. XM_047417377.1 → XP_047273333.1  erbin isoform X2

      Related
      ENSP00000425728.2, ENST00000511671.6

    7. XM_047417379.1 → XP_047273335.1  erbin isoform X4

      UniProtKB/TrEMBL
      A0A8V8TPC7
      Related
      ENSP00000514083.1, ENST00000699005.1

    8. XM_047417381.1 → XP_047273337.1  erbin isoform X6

    9. XM_047417383.1 → XP_047273339.1  erbin isoform X8

    10. XM_047417385.1 → XP_047273341.1  erbin isoform X10

      UniProtKB/TrEMBL
      A0A8V8TML4
      Related
      ENSP00000514089.1, ENST00000699010.1

    11. XM_005248554.4 → XP_005248611.1  erbin isoform X1

      See identical proteins and their annotated locations for XP_005248611.1

      UniProtKB/TrEMBL
      Q1RMC9
      Conserved Domains (5) summary
      cd00116
      Location:48 → 209
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00992
      Location:1369 → 1455
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00033
      Location:24 → 47
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:368 → 411
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:322 → 380
      LRR_8; Leucine rich repeat

    12. XM_047417386.1 → XP_047273342.1  erbin isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      66748417..66903759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352922.1 → XP_054208897.1  erbin isoform X1

    2. XM_054352925.1 → XP_054208900.1  erbin isoform X3

    3. XM_054352927.1 → XP_054208902.1  erbin isoform X5

      UniProtKB/Swiss-Prot
      A0AVR1, B4E3F1, B7ZLV9, E7EQW9, E9PCR8, Q1RMD0, Q86W38, Q96RT1, Q9NR18, Q9NW48, Q9ULJ5

    4. XM_054352929.1 → XP_054208904.1  erbin isoform X7

    5. XM_054352931.1 → XP_054208906.1  erbin isoform X9

    6. XM_054352924.1 → XP_054208899.1  erbin isoform X2

    7. XM_054352926.1 → XP_054208901.1  erbin isoform X4

    8. XM_054352928.1 → XP_054208903.1  erbin isoform X6

    9. XM_054352930.1 → XP_054208905.1  erbin isoform X8

    10. XM_054352932.1 → XP_054208907.1  erbin isoform X10

      UniProtKB/TrEMBL
      A0A8V8TML4

    11. XM_054352923.1 → XP_054208898.1  erbin isoform X1

    12. XM_054352933.1 → XP_054208908.1  erbin isoform X11

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96RT1.2 GenPept UniProtKB/Swiss-Prot:Q96RT1

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