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    XAGE2 X antigen family member 2 [ Homo sapiens (human) ]

    Gene ID: 9502, updated on 19-Sep-2024

    Summary

    Official Symbol
    XAGE2provided by HGNC
    Official Full Name
    X antigen family member 2provided by HGNC
    Primary source
    HGNC:HGNC:4112
    See related
    Ensembl:ENSG00000155622 MIM:300416; AllianceGenome:HGNC:4112
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT12.2; GAGED3; XAGE-2; XAGE2B
    Summary
    This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in normal testis, and in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer and a germ cell tumor. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward placenta (RPKM 70.1) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See XAGE2 in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (52369021..52375680)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (51640755..51647414)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (52112164..52118823)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:52089469-52090668 Neighboring gene microRNA 8088 Neighboring gene uncharacterized LOC124905189 Neighboring gene X antigen family member 5-like Neighboring gene RNA binding motif protein 22 pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    X antigen family member 2
    Names
    G antigen family D member 3
    X antigen family, member 2B
    cancer/testis antigen 12.2
    cancer/testis antigen family 12, member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130777.3NP_570133.1  X antigen family member 2

      See identical proteins and their annotated locations for NP_570133.1

      Status: REVIEWED

      Source sequence(s)
      AJ318880, H53211
      Consensus CDS
      CCDS59525.1
      UniProtKB/Swiss-Prot
      Q5HYR4, Q96GT9
      Related
      ENSP00000286049.2, ENST00000286049.3
      Conserved Domains (1) summary
      pfam05831
      Location:1105
      GAGE; GAGE protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      52369021..52375680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530836.3XP_011529138.1  X antigen family member 2 isoform X1

      See identical proteins and their annotated locations for XP_011529138.1

      UniProtKB/Swiss-Prot
      Q5HYR4, Q96GT9
      Conserved Domains (1) summary
      pfam05831
      Location:1105
      GAGE; GAGE protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      51640755..51647414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328181.1XP_054184156.1  X antigen family member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5HYR4, Q96GT9