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    SLC16A7 solute carrier family 16 member 7 [ Homo sapiens (human) ]

    Gene ID: 9194, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SLC16A7provided by HGNC
    Official Full Name
    solute carrier family 16 member 7provided by HGNC
    Primary source
    HGNC:HGNC:10928
    See related
    Ensembl:ENSG00000118596 MIM:603654; AllianceGenome:HGNC:10928
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCT2
    Summary
    This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
    Expression
    Broad expression in fat (RPKM 11.7), heart (RPKM 9.2) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC16A7 in Genome Data Viewer
    Location:
    12q14.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (59596029..59789841)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (59572554..59766418)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (59989810..60183622)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6575 Neighboring gene RNA, U4 small nuclear 20, pseudogene Neighboring gene polyadenylate-binding protein 4-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:60265054-60265568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:60265569-60266081 Neighboring gene uncharacterized LOC124903070

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function. Medel V, et al. Proc Natl Acad Sci U S A, 2022 Aug 16. PMID 35939682, Free PMC Article
    2. Relative distribution of three major lactate transporters in frozen human tissues and their localization in unfixed skeletal muscle. Fishbein WN, et al. Muscle Nerve, 2002 Jul. PMID 12115955
    3. Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: an immunohistochemical study. Chiry O, et al. Brain Res, 2008 Aug 21. PMID 18598673
    4. Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype. Moncrieffe H, et al. Pharmacogenet Genomics, 2010 Nov. PMID 20827233, Free PMC Article
    5. Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines. Hussien R, et al. Physiol Genomics, 2011 Mar 16. PMID 21177384, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.
      Title: Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.
    2. Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function.
      Title: Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function.
    3. Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.
      Title: Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.
    4. Cooperative transport mechanism of human monocarboxylate transporter 2.
      Title: Cooperative transport mechanism of human monocarboxylate transporter 2.
    5. the present study reports that the combination of tumour stroma percentage and tumour cell expression of cytoplasmic MCT-2 or nuclear LDH-5 is associated with poor prognosis.
      Title: The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer.
    6. MCT2 dictates the mode of action of N-oxalylglycine (NOG) by determining its intracellular concentration
      Title: MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.
    7. Adipocytes promote malignant growth of breast tumors with MCT2 expression via beta-hydroxybutyrate.
      Title: Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate.
    8. SLC16A7 (MCT2) epigenetic regulation results in protein over-expression, affecting signalling and cellular phenotypes in prostate cancer
      Title: Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer.
    9. Data suggest that monocarboxylate transporter 2 (MCT2) at peroxisomes is related to an increase in beta-oxidation levels which may be crucial for malignant transformation.
      Title: Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer.
    10. This study identified that CGPs was found to significantly correlate with the differential expression and methylation of genes encoding solute carrier family 16, member 7.
      Title: Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lactate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lactate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pyruvate secondary active transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables pyruvate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lactate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane lactate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in parallel fiber to Purkinje cell synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 2
    Names
    solute carrier family 16 (monocarboxylate transporter), member 7
    solute carrier family 16, member 7 (monocarboxylic acid transporter 2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270622.2 → NP_001257551.1  monocarboxylate transporter 2

      See identical proteins and their annotated locations for NP_001257551.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC079905, AC119793, AF058056, BC007463, BC030693, DR000391
      Consensus CDS
      CCDS8961.1
      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3
      UniProtKB/TrEMBL
      F8W0N3
      Related
      ENSP00000449547.1, ENST00000552432.5
      Conserved Domains (1) summary
      TIGR00892
      Location:15 → 458
      2A0113; monocarboxylate transporter 1

    2. NM_001270623.2 → NP_001257552.1  monocarboxylate transporter 2

      See identical proteins and their annotated locations for NP_001257552.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC079905, AC119793, AF049608, AF058056, BC007463, BC030693, DR000391
      Consensus CDS
      CCDS8961.1
      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3
      UniProtKB/TrEMBL
      F8W0N3
      Related
      ENSP00000448071.1, ENST00000547379.6
      Conserved Domains (1) summary
      TIGR00892
      Location:15 → 458
      2A0113; monocarboxylate transporter 1

    3. NM_004731.5 → NP_004722.2  monocarboxylate transporter 2

      See identical proteins and their annotated locations for NP_004722.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC079905, AF058056, BC030693
      Consensus CDS
      CCDS8961.1
      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3
      UniProtKB/TrEMBL
      F8W0N3
      Related
      ENSP00000261187.4, ENST00000261187.8
      Conserved Domains (1) summary
      TIGR00892
      Location:15 → 458
      2A0113; monocarboxylate transporter 1

    RNA

    1. NR_073055.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' end and uses two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC079905, AF058056, AK301725, BC030693

    2. NR_073056.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' end and uses two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC079905, AF058056, AK310281, BC030693

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      59596029..59789841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538989.3 → XP_011537291.1  monocarboxylate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_011537291.1

      UniProtKB/TrEMBL
      F8W0N3
      Conserved Domains (2) summary
      cd06174
      Location:20 → 449
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:15 → 484
      2A0113; monocarboxylate transporter 1

    2. XM_011538992.3 → XP_011537294.1  monocarboxylate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_011537294.1

      UniProtKB/TrEMBL
      F8W0N3
      Conserved Domains (2) summary
      cd06174
      Location:20 → 449
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:15 → 484
      2A0113; monocarboxylate transporter 1

    3. XM_024449276.2 → XP_024305044.1  monocarboxylate transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3
      UniProtKB/TrEMBL
      F8W0N3
      Conserved Domains (1) summary
      TIGR00892
      Location:15 → 458
      2A0113; monocarboxylate transporter 1

    4. XM_011538991.3 → XP_011537293.1  monocarboxylate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_011537293.1

      UniProtKB/TrEMBL
      F8W0N3
      Conserved Domains (2) summary
      cd06174
      Location:20 → 449
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:15 → 484
      2A0113; monocarboxylate transporter 1

    5. XM_005269231.4 → XP_005269288.1  monocarboxylate transporter 2 isoform X2

      See identical proteins and their annotated locations for XP_005269288.1

      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3
      UniProtKB/TrEMBL
      F8W0N3
      Related
      ENSP00000446722.1, ENST00000548610.5
      Conserved Domains (1) summary
      TIGR00892
      Location:15 → 458
      2A0113; monocarboxylate transporter 1

    6. XM_011538990.4 → XP_011537292.1  monocarboxylate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_011537292.1

      UniProtKB/TrEMBL
      F8W0N3
      Conserved Domains (2) summary
      cd06174
      Location:20 → 449
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:15 → 484
      2A0113; monocarboxylate transporter 1

    7. XM_017020226.3 → XP_016875715.1  monocarboxylate transporter 2 isoform X3

      UniProtKB/TrEMBL
      B4DWX9
      Conserved Domains (1) summary
      cd06174
      Location:1 → 324
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    8. XM_011538995.3 → XP_011537297.1  monocarboxylate transporter 2 isoform X3

      See identical proteins and their annotated locations for XP_011537297.1

      UniProtKB/TrEMBL
      B4DWX9
      Conserved Domains (1) summary
      cd06174
      Location:1 → 324
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    9. XM_047429885.1 → XP_047285841.1  monocarboxylate transporter 2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      59572554..59766418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373834.1 → XP_054229809.1  monocarboxylate transporter 2 isoform X1

    2. XM_054373837.1 → XP_054229812.1  monocarboxylate transporter 2 isoform X1

    3. XM_054373838.1 → XP_054229813.1  monocarboxylate transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3

    4. XM_054373839.1 → XP_054229814.1  monocarboxylate transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3

    5. XM_054373836.1 → XP_054229811.1  monocarboxylate transporter 2 isoform X1

    6. XM_054373835.1 → XP_054229810.1  monocarboxylate transporter 2 isoform X1

    7. XM_054373840.1 → XP_054229815.1  monocarboxylate transporter 2 isoform X3

    8. XM_054373841.1 → XP_054229816.1  monocarboxylate transporter 2 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60669.2 GenPept UniProtKB/Swiss-Prot:O60669

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