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    MIF4GD MIF4G domain containing [ Homo sapiens (human) ]

    Gene ID: 57409, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MIF4GDprovided by HGNC
    Official Full Name
    MIF4G domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:24030
    See related
    Ensembl:ENSG00000125457 MIM:612072; AllianceGenome:HGNC:24030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIFD; AD023; SLIP1
    Summary
    This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
    Expression
    Ubiquitous expression in lymph node (RPKM 9.4), bone marrow (RPKM 8.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MIF4GD in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75266228..75271292, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76158321..76163378, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73262309..73267373, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:73201514-73202447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73203873-73204440 Neighboring gene nucleoporin 85 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73220785-73221286 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:73221550-73222749 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73230746-73230909 Neighboring gene Sharpr-MPRA regulatory region 15557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12738 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12740 Neighboring gene Sharpr-MPRA regulatory region 8279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12741 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73257869-73258746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8960 Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8961 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73268227-73269014 Neighboring gene MIF4GD divergent transcript Neighboring gene solute carrier family 25 member 19 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:73284659-73285160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8963 Neighboring gene uncharacterized LOC124904059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12750

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation. Neusiedler J, et al. RNA, 2012 Jun. PMID 22532700, Free PMC Article
    2. MIF4G domain containing protein regulates cell cycle and hepatic carcinogenesis by antagonizing CDK2-dependent p27 stability. Wan C, et al. Oncogene, 2015 Jan 8. PMID 24336329
    3. SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein. Cakmakci NG, et al. Mol Cell Biol, 2008 Feb. PMID 18025107, Free PMC Article
    4. Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1. Bansal N, et al. Biochemistry, 2013 Jan 22. PMID 23286197, Free PMC Article
    5. Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins. von Moeller H, et al. Nucleic Acids Res, 2013 Sep. PMID 23804756, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that MIF4GD is a potential regulator of p27-dependent cell proliferation in HCC.
      Title: MIF4G domain containing protein regulates cell cycle and hepatic carcinogenesis by antagonizing CDK2-dependent p27 stability.
    2. Data suggest that oligomerization and SLBP phosphorylation regulate SLBP-SLIP1-histone-mRNA complex formation/disassociation; sequential and ordered assembly is required.
      Title: Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1.
    3. This paper describes the oligomeric state of SLIP1 and the SLIP1-SLBP complex and how it is regulated by SLBP phosphorylation. Using alanine scanning mutagenesis, the authors demonstrate that the binding site on SLIP1 for SLBP lies close to the dimer interface. A single-point mutant near the SLIP1 homodimer interface abolished interaction with SLBP in vitro and reduced the abundance of histone mRNA in vivo.
      Title: Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1.
    4. INT6 and MIF4GD were observed to colocalize in cytoplasmic foci. It was concluded that INT6, by establishing interactions with MIF4GD and SLBP, plays an important role in translation of poly(A) minus histone mRNAs.
      Title: INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.
    5. downregulation of endogenous SLIP1 reduces the rate of translation of endogenous histone mRNA and also reduces cell viability.
      Title: SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC45027

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cap-dependent translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    part_of histone mRNA stem-loop binding complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    MIF4G domain-containing protein
    Names
    SLBP (stem loop binding protein)-interacting protein 1
    SLBP-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242498.2 → NP_001229427.1  MIF4G domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001229427.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variant 6, encodes the longest isoform (1).
      Source sequence(s)
      AC022211, AK300711, BC033759, BI752882
      Consensus CDS
      CCDS58598.1
      UniProtKB/TrEMBL
      A0A0S2Z5S7
      Related
      ENSP00000462459.1, ENST00000579297.5
      Conserved Domains (1) summary
      cl02652
      Location:75 → 220
      MIF4G; MIF4G domain

    2. NM_001242500.1 → NP_001229429.1  MIF4G domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_001229429.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 2, encodes isoform (2).
      Source sequence(s)
      AC022211, BC033759, BU190758
      Consensus CDS
      CCDS11719.1
      UniProtKB/TrEMBL
      A0A0S2Z5T5
      Conserved Domains (1) summary
      cl02652
      Location:68 → 213
      MIF4G; MIF4G domain

    3. NM_001242501.1 → NP_001229430.1  MIF4G domain-containing protein isoform 4

      See identical proteins and their annotated locations for NP_001229430.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 7-10, encodes isoform (4).
      Source sequence(s)
      BC033759, CA488406
      Consensus CDS
      CCDS56044.1
      UniProtKB/Swiss-Prot
      A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
      UniProtKB/TrEMBL
      A0A0S2Z5K9, J3QRZ6
      Related
      ENSP00000484245.1, ENST00000618645.5
      Conserved Domains (1) summary
      cl02652
      Location:8 → 179
      MIF4G; MIF4G domain

    4. NM_001363806.2 → NP_001350735.1  MIF4G domain-containing protein isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS92390.1
      UniProtKB/TrEMBL
      J3KSB8
      Related
      ENSP00000462412.1, ENST00000580571.5

    5. NM_001365751.1 → NP_001352680.1  MIF4G domain-containing protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 1, encodes the longest isoform (1).
      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS58598.1
      UniProtKB/TrEMBL
      A0A0S2Z5S7
      Conserved Domains (1) summary
      cl02652
      Location:75 → 220
      MIF4G; MIF4G domain

    6. NM_001365752.1 → NP_001352681.1  MIF4G domain-containing protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 4 and 8-10, encodes isoform (4).
      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS56044.1
      UniProtKB/Swiss-Prot
      A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
      UniProtKB/TrEMBL
      A0A0S2Z5K9, J3QRZ6
      Related
      ENSP00000464448.1, ENST00000580717.5
      Conserved Domains (1) summary
      cl02652
      Location:8 → 179
      MIF4G; MIF4G domain

    7. NM_001365753.1 → NP_001352682.1  MIF4G domain-containing protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 4, 7, 9, and 10, encodes isoform (4).
      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS56044.1
      UniProtKB/Swiss-Prot
      A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
      UniProtKB/TrEMBL
      A0A0S2Z5K9, J3QRZ6
      Conserved Domains (1) summary
      cl02652
      Location:8 → 179
      MIF4G; MIF4G domain

    8. NM_001365754.1 → NP_001352683.1  MIF4G domain-containing protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 4, 7, 8, and 10, encodes isoform (4).
      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS56044.1
      UniProtKB/Swiss-Prot
      A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
      UniProtKB/TrEMBL
      A0A0S2Z5K9, J3QRZ6
      Conserved Domains (1) summary
      cl02652
      Location:8 → 179
      MIF4G; MIF4G domain

    9. NM_001365755.1 → NP_001352684.1  MIF4G domain-containing protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 4 and 7-9, encodes isoform (4).
      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS56044.1
      UniProtKB/Swiss-Prot
      A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
      UniProtKB/TrEMBL
      A0A0S2Z5K9, J3QRZ6
      Conserved Domains (1) summary
      cl02652
      Location:8 → 179
      MIF4G; MIF4G domain

    10. NM_001370592.1 → NP_001357521.1  MIF4G domain-containing protein isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC022211, AF225422, BP308696
      Consensus CDS
      CCDS56044.1
      UniProtKB/Swiss-Prot
      A9UHW6, B4DUM7, Q8N4Q5, Q9HBL5
      UniProtKB/TrEMBL
      A0A0S2Z5K9, J3QRZ6
      Related
      ENSP00000321625.8, ENST00000325102.13
      Conserved Domains (1) summary
      cl02652
      Location:8 → 179
      MIF4G; MIF4G domain

    11. NM_001411093.1 → NP_001398022.1  MIF4G domain-containing protein isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022211
      Consensus CDS
      CCDS92391.1
      UniProtKB/TrEMBL
      J3QLJ5, J3QRZ6

    12. NM_020679.4 → NP_065730.2  MIF4G domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_065730.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variant 3, encodes isoform (2).
      Source sequence(s)
      AC022211, BC033759, BI752882, BX404175
      Consensus CDS
      CCDS11719.1
      UniProtKB/TrEMBL
      A0A0S2Z5T5
      Related
      ENSP00000245551.5, ENST00000245551.9
      Conserved Domains (1) summary
      cl02652
      Location:68 → 213
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      75266228..75271292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436457.1 → XP_047292413.1  MIF4G domain-containing protein isoform X6

    2. XM_047436452.1 → XP_047292408.1  MIF4G domain-containing protein isoform X4

      UniProtKB/TrEMBL
      J3QLJ5, J3QRZ6
      Related
      ENSP00000463579.1, ENST00000579119.5

    3. XM_047436454.1 → XP_047292410.1  MIF4G domain-containing protein isoform X9

    4. XM_047436448.1 → XP_047292404.1  MIF4G domain-containing protein isoform X2

    5. XM_047436455.1 → XP_047292411.1  MIF4G domain-containing protein isoform X5

    6. XM_047436444.1 → XP_047292400.1  MIF4G domain-containing protein isoform X1

    7. XM_047436458.1 → XP_047292414.1  MIF4G domain-containing protein isoform X8

      UniProtKB/TrEMBL
      J3KSB8

    8. XM_047436456.1 → XP_047292412.1  MIF4G domain-containing protein isoform X10

    9. XM_047436450.1 → XP_047292406.1  MIF4G domain-containing protein isoform X7

      UniProtKB/TrEMBL
      A0A0S2Z5S7
      Related
      ENSP00000463334.1, ENST00000577542.5

    10. XM_047436445.1 → XP_047292401.1  MIF4G domain-containing protein isoform X1

    11. XM_047436447.1 → XP_047292403.1  MIF4G domain-containing protein isoform X1

    12. XM_011525055.3 → XP_011523357.2  MIF4G domain-containing protein isoform X8

      UniProtKB/TrEMBL
      J3KSB8

    13. XM_047436449.1 → XP_047292405.1  MIF4G domain-containing protein isoform X6

    14. XM_047436443.1 → XP_047292399.1  MIF4G domain-containing protein isoform X4

      UniProtKB/TrEMBL
      J3QLJ5, J3QRZ6

    15. XM_011525052.3 → XP_011523354.2  MIF4G domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z5T5

    16. XM_047436442.1 → XP_047292398.1  MIF4G domain-containing protein isoform X2

    17. XM_011525054.3 → XP_011523356.2  MIF4G domain-containing protein isoform X5

    18. XM_047436441.1 → XP_047292397.1  MIF4G domain-containing protein isoform X1

    19. XM_047436451.1 → XP_047292407.1  MIF4G domain-containing protein isoform X7

      UniProtKB/TrEMBL
      A0A0S2Z5S7
      Related
      ENSP00000462655.2, ENST00000579194.6

    20. XM_047436446.1 → XP_047292402.1  MIF4G domain-containing protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      76158321..76163378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316743.1 → XP_054172718.1  MIF4G domain-containing protein isoform X6

    2. XM_054316738.1 → XP_054172713.1  MIF4G domain-containing protein isoform X4

      UniProtKB/TrEMBL
      J3QLJ5, J3QRZ6

    3. XM_054316740.1 → XP_054172715.1  MIF4G domain-containing protein isoform X9

    4. XM_054316733.1 → XP_054172708.1  MIF4G domain-containing protein isoform X2

    5. XM_054316741.1 → XP_054172716.1  MIF4G domain-containing protein isoform X5

    6. XM_054316729.1 → XP_054172704.1  MIF4G domain-containing protein isoform X1

    7. XM_054316744.1 → XP_054172719.1  MIF4G domain-containing protein isoform X8

      UniProtKB/TrEMBL
      J3KSB8

    8. XM_054316742.1 → XP_054172717.1  MIF4G domain-containing protein isoform X10

    9. XM_054316736.1 → XP_054172711.1  MIF4G domain-containing protein isoform X7

      UniProtKB/TrEMBL
      A0A0S2Z5S7

    10. XM_054316730.1 → XP_054172705.1  MIF4G domain-containing protein isoform X1

    11. XM_054316732.1 → XP_054172707.1  MIF4G domain-containing protein isoform X1

    12. XM_054316739.1 → XP_054172714.1  MIF4G domain-containing protein isoform X8

      UniProtKB/TrEMBL
      J3KSB8

    13. XM_054316735.1 → XP_054172710.1  MIF4G domain-containing protein isoform X6

    14. XM_054316728.1 → XP_054172703.1  MIF4G domain-containing protein isoform X4

      UniProtKB/TrEMBL
      J3QLJ5, J3QRZ6

    15. XM_054316727.1 → XP_054172702.1  MIF4G domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z5T5

    16. XM_054316726.1 → XP_054172701.1  MIF4G domain-containing protein isoform X2

    17. XM_054316734.1 → XP_054172709.1  MIF4G domain-containing protein isoform X5

    18. XM_054316725.1 → XP_054172700.1  MIF4G domain-containing protein isoform X1

    19. XM_054316737.1 → XP_054172712.1  MIF4G domain-containing protein isoform X7

      UniProtKB/TrEMBL
      A0A0S2Z5S7

    20. XM_054316731.1 → XP_054172706.1  MIF4G domain-containing protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A9UHW6.1 GenPept UniProtKB/Swiss-Prot:A9UHW6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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