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    ELOA elongin A [ Homo sapiens (human) ]

    Gene ID: 6924, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ELOAprovided by HGNC
    Official Full Name
    elongin Aprovided by HGNC
    Primary source
    HGNC:HGNC:11620
    See related
    Ensembl:ENSG00000011007 MIM:600786; AllianceGenome:HGNC:11620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIII; ELOA1; TCEB3; TCEB3A; SIII p110
    Summary
    This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lung (RPKM 15.9), thyroid (RPKM 14.1) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See ELOA in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23743471..23762059)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23578438..23597030)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (24069961..24088549)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 48 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24024040-24024661 Neighboring gene ribosomal protein L11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 376 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 420 Neighboring gene Sharpr-MPRA regulatory region 2978 Neighboring gene ELOA antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12147 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:24103632-24104584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 422 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:24105838-24107037 Neighboring gene PITH domain containing 1 Neighboring gene uncharacterized LOC105376860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 423 Neighboring gene lysophospholipase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1. Aso T, et al. Genomics, 1995 Nov 20. PMID 8586449
    2. A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin. Aso T, et al. Gene, 1996 Feb 12. PMID 8654961
    3. Factors regulating the transcriptional elongation activity of RNA polymerase II. Shilatifard A. FASEB J, 1998 Nov. PMID 9806752
    4. TCEB3C a putative tumor suppressor gene of small intestinal neuroendocrine tumors. Edfeldt K, et al. Endocr Relat Cancer, 2014 Apr. PMID 24351681
    5. TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1. Cai Y, et al. FASEB J, 2024 Apr 30. PMID 38661028

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1.
      Title: TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1.
    2. Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.
      Title: Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.
    3. the Elongin A ubiquitin ligase and the CSB protein function together in a common pathway in response to Pol II stalling and DNA damage
      Title: Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.
    4. TCEB3C is a putative tumor suppressor gene of small intestinal neuroendocrine tumors
      Title: TCEB3C a putative tumor suppressor gene of small intestinal neuroendocrine tumors.
    5. Elongin A transcription elongation activity, but not its ubiquitination activity, is most important for its function in induction of transcription of ATF3 and p21.
      Title: Transcriptional properties of mammalian elongin A and its role in stress response.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of transcription elongation factor B (SIII), polypeptide 3 (TCEB3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
    Knockdown of transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A; TCEB3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef expression in HeLa cells upregulates transcription elongation factor B (SIII; elongin A) expression PubMed
    Tat tat The C-terminal 34 residues (1329-1362) of BRD4 are crucial for interaction with P-TEFb. Overexpression of the BRD4 P-TEFb-interacting domain disrupts the interaction between HIV-1 Tat and P-TEFb PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ38760, FLJ42849

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of elongin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in site of DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    elongin-A
    Names
    RNA polymerase II transcription factor SIII subunit A1
    elongin 110 kDa subunit
    transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
    transcription elongation factor B alpha subunit
    transcription elongation factor B polypeptide 3
    transcription elongation factor B subunit 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003198.3 → NP_003189.3  elongin-A

      Status: REVIEWED

      Source sequence(s)
      AL031295
      Consensus CDS
      CCDS239.3
      UniProtKB/Swiss-Prot
      B2R7Q8, Q14241, Q8IXH1
      Related
      ENSP00000484196.2, ENST00000613537.5
      Conserved Domains (3) summary
      cd00183
      Location:37 → 76
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      TIGR01385
      Location:37 → 127
      TFSII; transcription elongation factor S-II
      pfam06881
      Location:566 → 664
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      23743471..23762059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      23578438..23597030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14241.3 GenPept UniProtKB/Swiss-Prot:Q14241

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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