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    PRR5L proline rich 5 like [ Homo sapiens (human) ]

    Gene ID: 79899, updated on 26-Nov-2024

    Summary

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    Official Symbol
    PRR5Lprovided by HGNC
    Official Full Name
    proline rich 5 likeprovided by HGNC
    Primary source
    HGNC:HGNC:25878
    See related
    Ensembl:ENSG00000135362 MIM:611728; AllianceGenome:HGNC:25878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PROTOR2
    Summary
    Enables ubiquitin protein ligase binding activity. Involved in several processes, including TORC2 signaling; positive regulation of intracellular protein transport; and regulation of fibroblast migration. Part of TORC2 complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen (RPKM 11.6), colon (RPKM 10.9) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PRR5L in Genome Data Viewer
    Location:
    11p13-p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (36296288..36465204)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (36436630..36607651)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (36317838..36486754)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 3 Neighboring gene uncharacterized LOC101928510 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36111937-36112464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36112465-36112991 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21313 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36127161-36128105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36128106-36129049 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:36129695-36130220 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36130221-36130744 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36131269-36131792 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36132843-36133366 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36165205-36165812 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:36170828-36172027 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21355 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:36200889-36201107 Neighboring gene Sharpr-MPRA regulatory region 9208 Neighboring gene Sharpr-MPRA regulatory region 15199 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36310336-36311038 Neighboring gene COMM domain containing 9 Neighboring gene Sharpr-MPRA regulatory region 5372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:36398745-36399316 Neighboring gene Sharpr-MPRA regulatory region 14138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36476801-36477325 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:36522348-36523547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4633 Neighboring gene TNF receptor associated factor 6 Neighboring gene recombination activating 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. Thedieck K, et al. PLoS One, 2007 Nov 21. PMID 18030348, Free PMC Article
    2. Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. Holmes B, et al. Cell Signal, 2012 Jan. PMID 21964062, Free PMC Article
    3. Hsp70 associates with Rictor and is required for mTORC2 formation and activity. Martin J, et al. Biochem Biophys Res Commun, 2008 Aug 8. PMID 18505677, Free PMC Article
    4. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Gan X, et al. Nat Cell Biol, 2012 May 20. PMID 22609986, Free PMC Article
    5. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Pearce LR, et al. Biochem J, 2007 Aug 1. PMID 17461779, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TORC2 signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proline-rich protein 5-like
    Names
    Protein observed with Rictor-2
    protor-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160167.2 → NP_001153639.1  proline-rich protein 5-like isoform a

      See identical proteins and their annotated locations for NP_001153639.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC009656, AK055042, BX640959, DA344861, DA449593
      Consensus CDS
      CCDS31463.1
      UniProtKB/Swiss-Prot
      A4QN22, E9PKY1, Q6MZQ0, Q96H46, Q9H7V4
      UniProtKB/TrEMBL
      B3KNU3
      Related
      ENSP00000435050.1, ENST00000530639.6
      Conserved Domains (1) summary
      pfam08539
      Location:49 → 168
      HbrB; HbrB-like

    2. NM_001160168.2 → NP_001153640.1  proline-rich protein 5-like isoform b

      See identical proteins and their annotated locations for NP_001153640.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate AUG and a shorter isoform (b) compared to isoform a.
      Source sequence(s)
      AC009656, AK024275, BX640959, DA458327
      UniProtKB/Swiss-Prot
      Q6MZQ0
      Related
      ENST00000389693.3
      Conserved Domains (1) summary
      pfam08539
      Location:5 → 100
      HbrB; HbrB-like

    3. NM_001160169.1 → NP_001153641.1  proline-rich protein 5-like isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC009656, BC008922, BX640959, DA344861, DR001466
      Consensus CDS
      CCDS53617.1
      UniProtKB/Swiss-Prot
      Q6MZQ0
      Related
      ENSP00000435241.1, ENST00000527487.1
      Conserved Domains (1) summary
      pfam08539
      Location:49 → 168
      HbrB; HbrB-like

    4. NM_024841.5 → NP_079117.3  proline-rich protein 5-like isoform a

      See identical proteins and their annotated locations for NP_079117.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC009656, BX640959, DA344861, DA458327
      Consensus CDS
      CCDS31463.1
      UniProtKB/Swiss-Prot
      A4QN22, E9PKY1, Q6MZQ0, Q96H46, Q9H7V4
      UniProtKB/TrEMBL
      B3KNU3
      Related
      ENSP00000368144.3, ENST00000378867.7
      Conserved Domains (1) summary
      pfam08539
      Location:49 → 168
      HbrB; HbrB-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      36296288..36465204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      36436630..36607651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6MZQ0.2 GenPept UniProtKB/Swiss-Prot:Q6MZQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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