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    HOMER2 homer scaffold protein 2 [ Homo sapiens (human) ]

    Gene ID: 9455, updated on 2-Nov-2024

    Summary

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    Official Symbol
    HOMER2provided by HGNC
    Official Full Name
    homer scaffold protein 2provided by HGNC
    Primary source
    HGNC:HGNC:17513
    See related
    Ensembl:ENSG00000103942 MIM:604799; AllianceGenome:HGNC:17513
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPD; ACPD; DFNA68; VESL-2; HOMER-2
    Summary
    This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]
    Expression
    Broad expression in prostate (RPKM 9.3), pancreas (RPKM 6.8) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HOMER2 in Genome Data Viewer
    Location:
    15q25.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (82834661..82986157, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (80701241..80850554, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (83517735..83621472, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene actin gamma 1 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9965 Neighboring gene MPRA-validated peak2404 silencer Neighboring gene small Cajal body-specific RNA 15 Neighboring gene small nucleolar RNA host gene 21 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:83450989-83451154 Neighboring gene fibronectin type III and SPRY domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6756 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:83501038-83502237 Neighboring gene WASP homolog associated with actin, golgi membranes and microtubules Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:83518553-83519328 Neighboring gene uncharacterized LOC105370928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:83620722-83621222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:83632148-83632648 Neighboring gene Sharpr-MPRA regulatory region 12194 Neighboring gene chromosome 15 open reading frame 40 Neighboring gene uncharacterized LOC124903542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9968 Neighboring gene RNA guanine-7 methyltransferase activating subunit Neighboring gene BTB domain containing 1 Neighboring gene fatty acid binding protein 5 pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Potential role of Homer-2a on cutaneous vascular anomaly. Kim JT, et al. J Korean Med Sci, 2002 Oct. PMID 12378015, Free PMC Article
    2. Replicated genetic evidence supports a role for HOMER2 in schizophrenia. Gilks WP, et al. Neurosci Lett, 2010 Jan 14. PMID 19914345
    3. A Novel Truncating Mutation in HOMER2 Causes Nonsyndromic Progressive DFNA68 Hearing Loss in a Spanish Family. Lachgar M, et al. Genes (Basel), 2021 Mar 12. PMID 33809266, Free PMC Article
    4. Whole exome sequencing identified a second pathogenic variant in HOMER2 for autosomal dominant non-syndromic deafness. Lu X, et al. Clin Genet, 2018 Nov. PMID 30047143
    5. Overexpression of HOMER2 predicts better outcome in low-grade endometrioid endometrial adenocarcinoma. Mhawech-Fauceglia P, et al. Pathology, 2018 Aug. PMID 29891190, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and in vivo functional investigation of a HOMER2 nonstop variant causing hearing loss.
      Title: Identification and in vivo functional investigation of a HOMER2 nonstop variant causing hearing loss.
    2. A Novel Truncating Mutation in HOMER2 Causes Nonsyndromic Progressive DFNA68 Hearing Loss in a Spanish Family.
      Title: A Novel Truncating Mutation in HOMER2 Causes Nonsyndromic Progressive DFNA68 Hearing Loss in a Spanish Family.
    3. we have identified a distinct, novel insertion variant in HOMER2, which provides validating evidence that HOMER2 is indeed required for normal hearing. Its sequence alteration is responsible for late-onset, autosomal dominant, non-syndromic, SNHL in humans.
      Title: Whole exome sequencing identified a second pathogenic variant in HOMER2 for autosomal dominant non-syndromic deafness.
    4. that HOMER2 may be involved in tumourigenesis of endometrioid uterine tumours
      Title: Overexpression of HOMER2 predicts better outcome in low-grade endometrioid endometrial adenocarcinoma.
    5. Homer1 and Homer2 might be considered as novel diagnostic biomarkers for large-artery atherosclerosis stroke.
      Title: Diagnostic Potential of Differentially Expressed Homer1 and Homer2 in Ischemic Stroke.
    6. This study showed that HOMER2 (rs1256429; intronic, p = 8.7 x 10(1)) associated with Alzheimer disease.
      Title: Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts.
    7. These data provide compelling evidence that HOMER2 is required for normal hearing and that its sequence alteration in humans leads to ADNSHL through a dominant-negative mode of action
      Title: HOMER2, a stereociliary scaffolding protein, is essential for normal hearing in humans and mice.
    8. monitored Homer1 and Homer2 expression and subcellular localization in skeletal muscle biopsies following 60 days of bedrest
      Title: Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise.
    9. Haplotypes of the HOMER 1 and 2 genes are unlikely to play a major role in the pathophysiology of alcohol dependence.
      Title: No association of alcohol dependence with HOMER 1 and 2 genetic variants.
    10. This study supports a role for HOMER2 gene in schizophrenia susceptibility.
      Title: Replicated genetic evidence supports a role for HOMER2 in schizophrenia.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Autosomal dominant nonsyndromic hearing loss 68
    MedGen: C4225240 OMIM: 616707 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables synaptic receptor adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in behavioral response to cocaine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stereocilium tip ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    homer protein homolog 2
    Names
    cupidin
    homer homolog 2
    homer homolog 3
    homer scaffolding protein 2
    homer, neuronal immediate early gene, 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029435.3 RefSeqGene

      Range
      38437..142174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004839.4 → NP_004830.2  homer protein homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_004830.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as HOMER-2A, uses an alternate in-frame splice site in the central coding region, compared to variant 2, resulting in an isoform (1) that is shorter than isoform 2.
      Source sequence(s)
      BC012109
      Consensus CDS
      CCDS45336.1
      UniProtKB/TrEMBL
      A8K9Q7
      Related
      ENSP00000407634.2, ENST00000450735.7
      Conserved Domains (2) summary
      cd01206
      Location:3 → 111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      TIGR02168
      Location:93 → 322
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_199330.3 → NP_955362.1  homer protein homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_955362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as HOMER-2B, represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      BI666912, CB321822, Y19026
      Consensus CDS
      CCDS45334.1
      UniProtKB/Swiss-Prot
      O95269, O95349, Q9NSB6, Q9NSB7, Q9NSB8, Q9UNT7
      UniProtKB/TrEMBL
      A8K9Q7
      Related
      ENSP00000305632.8, ENST00000304231.12
      Conserved Domains (2) summary
      cd01206
      Location:3 → 111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl25732
      Location:93 → 333
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      82834661..82986157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433359.1 → XP_047289315.1  homer protein homolog 2 isoform X7

    2. XM_047433356.1 → XP_047289312.1  homer protein homolog 2 isoform X5

    3. XM_011522232.3 → XP_011520534.1  homer protein homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011520534.1

      UniProtKB/TrEMBL
      A8K9Q7
      Conserved Domains (2) summary
      cd01206
      Location:13 → 121
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl25732
      Location:103 → 343
      SMC_N; RecF/RecN/SMC N terminal domain

    4. XM_047433360.1 → XP_047289316.1  homer protein homolog 2 isoform X8

    5. XM_047433358.1 → XP_047289314.1  homer protein homolog 2 isoform X7

    6. XM_047433355.1 → XP_047289311.1  homer protein homolog 2 isoform X4

      UniProtKB/Swiss-Prot
      O95269, O95349, Q9NSB6, Q9NSB7, Q9NSB8, Q9UNT7

    7. XM_047433357.1 → XP_047289313.1  homer protein homolog 2 isoform X5

    8. XM_006720775.4 → XP_006720838.1  homer protein homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006720838.1

      UniProtKB/TrEMBL
      A8K9Q7
      Conserved Domains (2) summary
      cd01206
      Location:13 → 121
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl25732
      Location:103 → 343
      SMC_N; RecF/RecN/SMC N terminal domain

    9. XM_005272449.5 → XP_005272506.1  homer protein homolog 2 isoform X6

      See identical proteins and their annotated locations for XP_005272506.1

      UniProtKB/TrEMBL
      A8K9Q7
      Conserved Domains (2) summary
      cd01206
      Location:3 → 111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl25732
      Location:149 → 338
      SMC_N; RecF/RecN/SMC N terminal domain

    10. XM_006720776.5 → XP_006720839.1  homer protein homolog 2 isoform X3

      UniProtKB/TrEMBL
      A8K9Q7
      Conserved Domains (2) summary
      cd01206
      Location:3 → 111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl23720
      Location:221 → 334
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    11. XM_047433361.1 → XP_047289317.1  homer protein homolog 2 isoform X8

    12. XM_011522233.4 → XP_011520535.1  homer protein homolog 2 isoform X2

      UniProtKB/TrEMBL
      A8K9Q7
      Conserved Domains (2) summary
      cd01206
      Location:11 → 119
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl23720
      Location:229 → 342
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    13. XM_047433362.1 → XP_047289318.1  homer protein homolog 2 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      80701241..80850554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379235.1 → XP_054235210.1  homer protein homolog 2 isoform X7

    2. XM_054379231.1 → XP_054235206.1  homer protein homolog 2 isoform X5

    3. XM_054379227.1 → XP_054235202.1  homer protein homolog 2 isoform X1

    4. XM_054379236.1 → XP_054235211.1  homer protein homolog 2 isoform X8

    5. XM_054379234.1 → XP_054235209.1  homer protein homolog 2 isoform X7

    6. XM_054379230.1 → XP_054235205.1  homer protein homolog 2 isoform X4

      UniProtKB/Swiss-Prot
      O95269, O95349, Q9NSB6, Q9NSB7, Q9NSB8, Q9UNT7

    7. XM_054379232.1 → XP_054235207.1  homer protein homolog 2 isoform X5

    8. XM_054379226.1 → XP_054235201.1  homer protein homolog 2 isoform X1

    9. XM_054379233.1 → XP_054235208.1  homer protein homolog 2 isoform X6

    10. XM_054379229.1 → XP_054235204.1  homer protein homolog 2 isoform X3

    11. XM_054379228.1 → XP_054235203.1  homer protein homolog 2 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199331.2: Suppressed sequence

      Description
      NM_199331.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_199332.2: Suppressed sequence

      Description
      NM_199332.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NSB8.1 GenPept UniProtKB/Swiss-Prot:Q9NSB8

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