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    ZSCAN20 zinc finger and SCAN domain containing 20 [ Homo sapiens (human) ]

    Gene ID: 7579, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZSCAN20provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 20provided by HGNC
    Primary source
    HGNC:HGNC:13093
    See related
    Ensembl:ENSG00000121903 MIM:611315; AllianceGenome:HGNC:13093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX29; ZNF31; ZFP-31; ZNF360
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See ZSCAN20 in Genome Data Viewer
    Location:
    1p35.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (33472645..33501643)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (33334198..33363244)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33938246..33967243)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr1:33821846-33822366 Neighboring gene VISTA enhancer hs1388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33832336-33833239 Neighboring gene PHC2 antisense RNA 1 Neighboring gene polyhomeotic homolog 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33920469-33920968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33933768-33934294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33934295-33934819 Neighboring gene Sharpr-MPRA regulatory region 11456 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:33975098-33976006 Neighboring gene proteasome 20S subunit alpha 3 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:33985189-33985725 Neighboring gene toll like receptor 12, pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7293 Neighboring gene CUB and Sushi multiple domains 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:34070585-34071784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:34073062-34073562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:34073563-34074063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:34099135-34099641 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:34100609-34101540 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:34101541-34102471 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:34102434-34102604 Neighboring gene uncharacterized LOC124903976

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Jordanova A, et al. Nat Genet, 2006 Feb. PMID 16429158
    2. PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. Choi SW, et al. Mol Cell, 2018 Jun 7. PMID 29883609
    3. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909
    4. Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. Fan Q, et al. Mol Vis, 2014. PMID 24453475, Free PMC Article
    5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. Chen Y, et al. Mol Cell Proteomics, 2013 Oct. PMID 23824909, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 20
    Names
    zinc finger protein 31
    zinc finger protein 360
    zinc finger protein KOX29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377376.1 → NP_001364305.1  zinc finger and SCAN domain-containing protein 20 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115285, AL138837
      Consensus CDS
      CCDS41300.1
      UniProtKB/Swiss-Prot
      A8K2D0, B1ALI4, B1ALI5, B1ALI6, P17040, Q6ZN23, Q96FA9, Q96H84
      Related
      ENSP00000507139.1, ENST00000684572.1
      Conserved Domains (4) summary
      COG5048
      Location:699 → 1029
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:740 → 760
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:47 → 132
      SCAN; SCAN domain
      pfam13837
      Location:323 → 404
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    2. NM_001377377.1 → NP_001364306.1  zinc finger and SCAN domain-containing protein 20 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115285, AL138837
      Conserved Domains (4) summary
      COG5048
      Location:698 → 1028
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:739 → 759
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:47 → 132
      SCAN; SCAN domain
      pfam13837
      Location:323 → 404
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    3. NM_001377378.1 → NP_001364307.1  zinc finger and SCAN domain-containing protein 20 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC115285, AL138837
      Conserved Domains (4) summary
      COG5048
      Location:645 → 975
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:686 → 706
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:47 → 132
      SCAN; SCAN domain
      pfam13837
      Location:269 → 350
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    4. NM_001377379.1 → NP_001364308.1  zinc finger and SCAN domain-containing protein 20 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC115285, AL138837
      Conserved Domains (3) summary
      COG5048
      Location:381 → 711
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:422 → 442
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13837
      Location:5 → 86
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    5. NM_145238.6 → NP_660281.3  zinc finger and SCAN domain-containing protein 20 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115285, AL138837
      Consensus CDS
      CCDS41300.1
      UniProtKB/Swiss-Prot
      A8K2D0, B1ALI4, B1ALI5, B1ALI6, P17040, Q6ZN23, Q96FA9, Q96H84
      Related
      ENSP00000355053.3, ENST00000361328.7
      Conserved Domains (4) summary
      COG5048
      Location:699 → 1029
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:740 → 760
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:47 → 132
      SCAN; SCAN domain
      pfam13837
      Location:323 → 404
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      33472645..33501643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429973.1 → XP_047285929.1  zinc finger and SCAN domain-containing protein 20 isoform X4

    2. XM_047429974.1 → XP_047285930.1  zinc finger and SCAN domain-containing protein 20 isoform X5

    3. XM_017002238.2 → XP_016857727.1  zinc finger and SCAN domain-containing protein 20 isoform X2

      UniProtKB/Swiss-Prot
      P17040
      Conserved Domains (4) summary
      COG5048
      Location:698 → 1028
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:739 → 759
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:47 → 132
      SCAN; SCAN domain
      pfam13837
      Location:323 → 404
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    4. XM_047429971.1 → XP_047285927.1  zinc finger and SCAN domain-containing protein 20 isoform X3

    5. XM_017002237.2 → XP_016857726.1  zinc finger and SCAN domain-containing protein 20 isoform X1

      UniProtKB/Swiss-Prot
      A8K2D0, B1ALI4, B1ALI5, B1ALI6, P17040, Q6ZN23, Q96FA9, Q96H84
      Conserved Domains (4) summary
      COG5048
      Location:699 → 1029
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:740 → 760
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:47 → 132
      SCAN; SCAN domain
      pfam13837
      Location:323 → 404
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    6. XM_047429970.1 → XP_047285926.1  zinc finger and SCAN domain-containing protein 20 isoform X2

    7. XM_047429972.1 → XP_047285928.1  zinc finger and SCAN domain-containing protein 20 isoform X3

    8. XM_017002241.2 → XP_016857730.1  zinc finger and SCAN domain-containing protein 20 isoform X6

      Conserved Domains (3) summary
      COG5048
      Location:381 → 711
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:422 → 442
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13837
      Location:5 → 86
      Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain

    9. XM_047429975.1 → XP_047285931.1  zinc finger and SCAN domain-containing protein 20 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      33334198..33363244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338614.1 → XP_054194589.1  zinc finger and SCAN domain-containing protein 20 isoform X1

    2. XM_054338616.1 → XP_054194591.1  zinc finger and SCAN domain-containing protein 20 isoform X2

    3. XM_054338618.1 → XP_054194593.1  zinc finger and SCAN domain-containing protein 20 isoform X3

    4. XM_054338619.1 → XP_054194594.1  zinc finger and SCAN domain-containing protein 20 isoform X4

    5. XM_054338620.1 → XP_054194595.1  zinc finger and SCAN domain-containing protein 20 isoform X5

    6. XM_054338615.1 → XP_054194590.1  zinc finger and SCAN domain-containing protein 20 isoform X2

    7. XM_054338617.1 → XP_054194592.1  zinc finger and SCAN domain-containing protein 20 isoform X3

    8. XM_054338621.1 → XP_054194596.1  zinc finger and SCAN domain-containing protein 20 isoform X6

    9. XM_054338622.1 → XP_054194597.1  zinc finger and SCAN domain-containing protein 20 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17040.3 GenPept UniProtKB/Swiss-Prot:P17040

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