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    Slc25a21 solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 [ Mus musculus (house mouse) ]

    Gene ID: 217593, updated on 6-Oct-2024

    Summary

    Official Symbol
    Slc25a21provided by MGI
    Official Full Name
    solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21provided by MGI
    Primary source
    MGI:MGI:2445059
    See related
    Ensembl:ENSMUSG00000035472 AllianceGenome:MGI:2445059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630030I10; 9930033G19Rik
    Summary
    Predicted to enable alpha-ketoglutarate transmembrane transporter activity. Predicted to be involved in mitochondrial alpha-ketoglutarate transmembrane transport. Located in mitochondrion. Is expressed in several structures, including integumental system; limb; liver; respiratory system; and skeleton. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome. Orthologous to human SLC25A21 (solute carrier family 25 member 21). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14 (RPKM 5.7), liver E14.5 (RPKM 5.5) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc25a21 in Genome Data Viewer
    Location:
    12 C1; 12 24.54 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (56759419..57244257, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (56712634..57197472, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CNS+2 enhancer downstream of Pax9 Neighboring gene predicted gene 15524 Neighboring gene predicted gene, 46352 Neighboring gene paired box 9 Neighboring gene STARR-seq mESC enhancer starr_32214 Neighboring gene STARR-seq mESC enhancer starr_32215 Neighboring gene STARR-seq mESC enhancer starr_32216 Neighboring gene predicted gene, 30001 Neighboring gene STARR-seq mESC enhancer starr_32218 Neighboring gene STARR-seq mESC enhancer starr_32219 Neighboring gene STARR-positive B cell enhancer ABC_E7135 Neighboring gene predicted gene, 40426 Neighboring gene phosphoribosyl pyrophosphate synthetase 1-like 3 Neighboring gene mirror-image polydactyly 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation
    • Transposon induced (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    mitochondrial 2-oxodicarboxylate carrier
    Names
    mitochondrial solute carrier family 25 member 21
    solute carrier family 25 member 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167976.1NP_001161448.1  mitochondrial 2-oxodicarboxylate carrier isoform 2

      See identical proteins and their annotated locations for NP_001161448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs at the 5' end compared to variant 1, and encodes a longer isoform (2) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK167535, EU180236
      Consensus CDS
      CCDS49069.1
      UniProtKB/TrEMBL
      B6CI26, Q3TRZ4
      Related
      ENSMUSP00000151751.2, ENSMUST00000217690.2
      Conserved Domains (1) summary
      pfam00153
      Location:29111
      Mito_carr; Mitochondrial carrier protein
    2. NM_172577.3NP_766165.2  mitochondrial 2-oxodicarboxylate carrier isoform 1

      See identical proteins and their annotated locations for NP_766165.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
      Source sequence(s)
      AK041694, AK162379, AK167535
      Consensus CDS
      CCDS25925.1
      UniProtKB/Swiss-Prot
      Q8BY72, Q8BZ09
      UniProtKB/TrEMBL
      Q3TRZ4
      Related
      ENSMUSP00000039289.6, ENSMUST00000044634.12
      Conserved Domains (2) summary
      PTZ00168
      Location:11280
      PTZ00168; mitochondrial carrier protein; Provisional
      pfam00153
      Location:14104
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      56759419..57244257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)