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    GNG8 G protein subunit gamma 8 [ Homo sapiens (human) ]

    Gene ID: 94235, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GNG8provided by HGNC
    Official Full Name
    G protein subunit gamma 8provided by HGNC
    Primary source
    HGNC:HGNC:19664
    See related
    Ensembl:ENSG00000167414 AllianceGenome:HGNC:19664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HG3E
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within cellular response to pheromone; nose development; and social behavior. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See GNG8 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46633953..46639326, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49459562..49464865, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47137210..47139459, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904729 Neighboring gene calmodulin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47119779-47120280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47120281-47120780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47124126-47124640 Neighboring gene prostaglandin I2 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47128561-47129061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10816 Neighboring gene Sharpr-MPRA regulatory region 2120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47157789-47158515 Neighboring gene dishevelled binding antagonist of beta catenin 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10821 Neighboring gene DACT3 antisense RNA 1 Neighboring gene protein kinase D2 Neighboring gene RNA, 7SL, cytoplasmic 364, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. Hurowitz EH, et al. DNA Res, 2000 Apr 28. PMID 10819326
    2. Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. El-Haibi CP, et al. Mol Cancer, 2013 Jun 18. PMID 23773523, Free PMC Article
    3. The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein. Sun Z, et al. Cell Signal, 2012 Dec. PMID 22940628, Free PMC Article
    4. The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction. Rosskopf D, et al. FEBS Lett, 2003 Jun 5. PMID 12782285
    5. Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families. Krishnan A, et al. Mol Phylogenet Evol, 2015 Oct. PMID 26002831

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nose development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in social behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
    Names
    gamma-9
    guanine nucleotide binding protein (G protein), gamma 8
    heterotrimeric guanine nucleotide-binding protein 3E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033258.2 → NP_150283.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

      See identical proteins and their annotated locations for NP_150283.1

      Status: VALIDATED

      Source sequence(s)
      AC093503
      Consensus CDS
      CCDS12687.1
      UniProtKB/Swiss-Prot
      Q4VBM5, Q9UK08
      Related
      ENSP00000508424.1, ENST00000693335.1
      Conserved Domains (1) summary
      smart00224
      Location:8 → 70
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      46633953..46639326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027505.1 → XP_016882994.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

      UniProtKB/Swiss-Prot
      Q4VBM5, Q9UK08
      Conserved Domains (1) summary
      smart00224
      Location:8 → 70
      GGL; G protein gamma subunit-like motifs

    2. XM_017027504.3 → XP_016882993.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

      UniProtKB/Swiss-Prot
      Q4VBM5, Q9UK08
      Related
      ENSP00000300873.3, ENST00000300873.5
      Conserved Domains (1) summary
      smart00224
      Location:8 → 70
      GGL; G protein gamma subunit-like motifs

    3. XM_047439725.1 → XP_047295681.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

      UniProtKB/Swiss-Prot
      Q4VBM5, Q9UK08

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      49459562..49464865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322688.1 → XP_054178663.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

      UniProtKB/Swiss-Prot
      Q4VBM5, Q9UK08

    2. XM_054322687.1 → XP_054178662.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

      UniProtKB/Swiss-Prot
      Q4VBM5, Q9UK08

    3. XM_054322686.1 → XP_054178661.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1

      UniProtKB/Swiss-Prot
      Q4VBM5, Q9UK08
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UK08.1 GenPept UniProtKB/Swiss-Prot:Q9UK08

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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