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    ELFN1-AS1 ELFN1 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 101927125, updated on 27-Aug-2024

    Summary

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    Official Symbol
    ELFN1-AS1provided by HGNC
    Official Full Name
    ELFN1 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:39071
    See related
    Ensembl:ENSG00000236081 AllianceGenome:HGNC:39071
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYCLo-2
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    7p22.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (1738630..1742310, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (1851189..1854870, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1778266..1781946, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901819 Neighboring gene extracellular leucine rich repeat and fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC105375124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1764307-1764893 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1772549-1773050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25499 Neighboring gene Sharpr-MPRA regulatory region 13438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1847611-1848112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1848113-1848612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1852667-1853242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1878277-1879182 Neighboring gene uncharacterized LOC100127955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1887449-1888158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1896343-1897150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1897151-1897958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1897959-1898765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1900385-1901202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1901203-1902019 Neighboring gene mitotic arrest deficient 1 like 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1902954-1903628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1913269-1914241 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1923010-1923799 Neighboring gene microRNA 4655 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:1930010-1930510 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:1930511-1931011 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:1940274-1941134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1951273-1951773 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1951951-1952584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1952585-1953218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1970348-1971296 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1979601-1980186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25503 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1985471-1986286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1986287-1987101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1994453-1995177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1997460-1998140 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:2000936-2002135 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:2019399-2020598 Neighboring gene uncharacterized LOC124901573

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. lncRNA ELFN1-AS1 promotes proliferation, migration and invasion and suppresses apoptosis in colorectal cancer cells by enhancing G6PD activity. Wu F, et al. Acta Biochim Biophys Sin (Shanghai), 2023 Feb 15. PMID 36786074, Free PMC Article
    2. ELFN1-AS1: a novel primate gene with possible microRNA function expressed predominantly in human tumors. Polev DE, et al. Biomed Res Int, 2014. PMID 24707484, Free PMC Article
    3. MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1. Li C, et al. Mol Cancer Res, 2022 Nov 3. PMID 35857351
    4. lncRNA ELFN1-AS1 predicts poor prognosis and promotes tumor progression of non-small cell lung cancer by sponging miR-497. Yang B, et al. Cancer Biomark, 2022. PMID 35431233
    5. lncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression. Huang J, et al. Acta Biochim Biophys Sin (Shanghai), 2023 Mar 25. PMID 36876422, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. m6A-related lncRNAs as potential biomarkers and the lncRNA ELFN1-AS1/miR-182-5p/BCL-2 regulatory axis in diffuse large B-cell lymphoma.
      Title: m6A-related lncRNAs as potential biomarkers and the lncRNA ELFN1-AS1/miR-182-5p/BCL-2 regulatory axis in diffuse large B-cell lymphoma.
    2. lncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression.
      Title: lncRNA ELFN1-AS1 upregulates TRIM29 by suppressing miR-211-3p to promote gastric cancer progression.
    3. lncRNA ELFN1-AS1 promotes proliferation, migration and invasion and suppresses apoptosis in colorectal cancer cells by enhancing G6PD activity.
      Title: lncRNA ELFN1-AS1 promotes proliferation, migration and invasion and suppresses apoptosis in colorectal cancer cells by enhancing G6PD activity.
    4. MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1.
      Title: MYC-Induced Upregulation of Lncrna ELFN1-AS1 Contributes to Tumor Growth in Colorectal Cancer via Epigenetically Silencing TPM1.
    5. lncRNA ELFN1-AS1 predicts poor prognosis and promotes tumor progression of non-small cell lung cancer by sponging miR-497.
      Title: lncRNA ELFN1-AS1 predicts poor prognosis and promotes tumor progression of non-small cell lung cancer by sponging miR-497.
    6. A long non-coding RNA, ELFN1-AS1, sponges miR-1250 to upregulate MTA1 to promote cell proliferation, migration and invasion, and induce apoptosis in colorectal cancer.
      Title: A long non-coding RNA, ELFN1-AS1, sponges miR-1250 to upregulate MTA1 to promote cell proliferation, migration and invasion, and induce apoptosis in colorectal cancer.
    7. LncRNA ELFN1-AS1 promotes esophageal cancer progression by up-regulating GFPT1 via sponging miR-183-3p.
      Title: LncRNA ELFN1-AS1 promotes esophageal cancer progression by up-regulating GFPT1 via sponging miR-183-3p.
    8. ELFN1-AS1 accelerates the proliferation and migration of colorectal cancer via regulation of miR-4644/TRIM44 axis.
      Title: ELFN1-AS1 accelerates the proliferation and migration of colorectal cancer via regulation of miR-4644/TRIM44 axis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Clone Names

    • AC074389.9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_120508.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC074389, BF665480, HY180852, JX046910

    2. NR_120509.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      HO663747, HY180852, JX046910

    3. NR_120510.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      HY180852, JX046910
      Related
      ENST00000453348.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      1738630..1742310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      1851189..1854870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials