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    DIO3OS DIO3 opposite strand upstream RNA [ Homo sapiens (human) ]

    Gene ID: 64150, updated on 22-Oct-2024

    Summary

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    Official Symbol
    DIO3OSprovided by HGNC
    Official Full Name
    DIO3 opposite strand upstream RNAprovided by HGNC
    Primary source
    HGNC:HGNC:20348
    See related
    Ensembl:ENSG00000258498 MIM:608523; AllianceGenome:HGNC:20348
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIO3-OS; DIO3-AS1; C14orf134; NCRNA00041
    Summary
    The mouse and human DIO3OS and DIO3 (MIM 601038) genes overlap and are transcribed in opposite directions. The mouse Dio3 gene is imprinted from the paternal allele during fetal development, suggesting that DIO3OS is a noncoding gene that may have a role in maintaining monoallelic expression of DIO3 (Hernandez et al., 2004 [PubMed 14962667]).[supplied by OMIM, Mar 2008]
    Orthologs
    mouse all
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    Genomic context

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    See DIO3OS in Genome Data Viewer
    Location:
    14q32.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (101552221..101560422, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (95787465..95795676, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102018558..102026759, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101988607-101989138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101989139-101989669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101991618-101992451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:101994118-101994949 Neighboring gene uncharacterized LOC105370674 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:102018566-102019765 Neighboring gene microRNA 1247 Neighboring gene iodothyronine deiodinase 3 Neighboring gene uncharacterized LOC105370675

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO-Mediated Nuclear Export of ZEB1 mRNA. Hou YR, et al. Adv Sci (Weinh), 2023 Aug. PMID 37271897, Free PMC Article
    2. KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease. Wang S, et al. Mol Med Rep, 2018 Feb. PMID 29207070, Free PMC Article
    3. Complex organization and structure of sense and antisense transcripts expressed from the DIO3 gene imprinted locus. Hernandez A, et al. Genomics, 2004 Mar. PMID 14962667
    4. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. Velez Edwards DR, et al. Hum Genet, 2013 Mar. PMID 23192594, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO-Mediated Nuclear Export of ZEB1 mRNA.
      Title: The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO-Mediated Nuclear Export of ZEB1 mRNA.
    2. there were significantly positive correlations in KIF9AS1, LINC01272 and DIO3OS expression between IBD tissue and plasma samples. Therefore, the present study indicated that KIF9AS1, LINC01272 and DIO3OS may be potential diagnostic biomarkers for IBD.
      Title: KIF9‑AS1, LINC01272 and DIO3OS lncRNAs as novel biomarkers for inflammatory bowel disease.
    3. We analyzed the human DIO3 genomic region and identified a gene (DIO3OS) that is transcribed in the antisense orientation.
      Title: Complex organization and structure of sense and antisense transcripts expressed from the DIO3 gene imprinted locus.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Other Names

    • DIO3 opposite strand (non-protein coding)
    • DIO3 opposite strand/antisense RNA (head to head)
    • DIO3 opposite strand/antisense RNA (non-protein coding)
    • deiodinase, iodothyronine, type III opposite strand
    • uterine-derived 14 kDa protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_152588.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF469208, AI983003, BC111049
      Related
      ENST00000557109.7

    2. NR_152589.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF305836, AF469200, BC111049
      Related
      ENST00000557532.7

    3. NR_152590.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF305836, AL049836, BC111049
      Related
      ENST00000555174.7

    4. NR_152591.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF305836, AF469199, BC065701, BC111049
      Related
      ENST00000554694.3

    5. NR_152592.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF305836, BC065701, BC111049
      Related
      ENST00000557661.3

    6. NR_152593.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF305836, AL049836, BC065701, BC111049, BI760536
      Related
      ENST00000554441.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      101552221..101560422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      95787465..95795676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_022345.2: Suppressed sequence

      Description
      NM_022345.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

    2. NR_002770.1: Suppressed sequence

      Description
      NR_002770.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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