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    LSMEM1 leucine rich single-pass membrane protein 1 [ Homo sapiens (human) ]

    Gene ID: 286006, updated on 9-Dec-2024

    Summary

    Official Symbol
    LSMEM1provided by HGNC
    Official Full Name
    leucine rich single-pass membrane protein 1provided by HGNC
    Primary source
    HGNC:HGNC:22036
    See related
    Ensembl:ENSG00000181016 AllianceGenome:HGNC:22036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C7orf53
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LSMEM1 in Genome Data Viewer
    Location:
    7q31.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (112480304..112491062)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (113797449..113809353)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (112120908..112131117)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375457 Neighboring gene Sharpr-MPRA regulatory region 10411 Neighboring gene interferon related developmental regulator 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:112089605-112090422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:112090423-112091240 Neighboring gene uncharacterized LOC128031837 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26513 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:112136767-112136980 Neighboring gene nucleophosmin 1 pseudogene 14 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:112181860-112182047 Neighboring gene long intergenic non-protein coding RNA 3076

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ39575, MGC42850, MGC161427, MGC163440

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leucine-rich single-pass membrane protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134468.2NP_001127940.1  leucine-rich single-pass membrane protein 1

      See identical proteins and their annotated locations for NP_001127940.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AA121517, AC005192, BC126149, DB456503
      Consensus CDS
      CCDS5756.1
      UniProtKB/Swiss-Prot
      Q49AR6, Q8N8F7
      Related
      ENSP00000389278.2, ENST00000439068.6
      Conserved Domains (1) summary
      pfam15145
      Location:1131
      DUF4577; Domain of unknown function (DUF4577)
    2. NM_182597.3NP_872403.1  leucine-rich single-pass membrane protein 1

      See identical proteins and their annotated locations for NP_872403.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AA121517, AC005192, BC126149, DA894907, DA898266
      Consensus CDS
      CCDS5756.1
      UniProtKB/Swiss-Prot
      Q49AR6, Q8N8F7
      Related
      ENSP00000323304.3, ENST00000312849.4
      Conserved Domains (1) summary
      pfam15145
      Location:1131
      DUF4577; Domain of unknown function (DUF4577)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      112480304..112491062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012028.3XP_016867517.1  leucine-rich single-pass membrane protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q49AR6, Q8N8F7
      Conserved Domains (1) summary
      pfam15145
      Location:1131
      DUF4577; Domain of unknown function (DUF4577)
    2. XM_011516074.3XP_011514376.1  leucine-rich single-pass membrane protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011514376.1

      UniProtKB/Swiss-Prot
      Q49AR6, Q8N8F7
      Conserved Domains (1) summary
      pfam15145
      Location:1131
      DUF4577; Domain of unknown function (DUF4577)
    3. XM_011516076.3XP_011514378.1  leucine-rich single-pass membrane protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011514378.1

      UniProtKB/Swiss-Prot
      Q49AR6, Q8N8F7
      Conserved Domains (1) summary
      pfam15145
      Location:1131
      DUF4577; Domain of unknown function (DUF4577)
    4. XM_011516075.3XP_011514377.1  leucine-rich single-pass membrane protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011514377.1

      UniProtKB/Swiss-Prot
      Q49AR6, Q8N8F7
      Conserved Domains (1) summary
      pfam15145
      Location:1131
      DUF4577; Domain of unknown function (DUF4577)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      113797449..113809353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357948.1XP_054213923.1  leucine-rich single-pass membrane protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q49AR6, Q8N8F7
    2. XM_054357950.1XP_054213925.1  leucine-rich single-pass membrane protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q49AR6, Q8N8F7
    3. XM_054357949.1XP_054213924.1  leucine-rich single-pass membrane protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q49AR6, Q8N8F7