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    Tmem258 transmembrane protein 258 [ Mus musculus (house mouse) ]

    Gene ID: 69038, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Tmem258provided by MGI
    Official Full Name
    transmembrane protein 258provided by MGI
    Primary source
    MGI:MGI:1916288
    See related
    Ensembl:ENSMUSG00000036372 AllianceGenome:MGI:1916288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810006K21Rik
    Summary
    Enables oligosaccharyltransferase complex binding activity. Acts upstream of or within several processes, including epithelial cell apoptotic process; protein N-linked glycosylation; and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human TMEM258 (transmembrane protein 258). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 111.7), placenta adult (RPKM 60.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem258 in Genome Data Viewer
    Location:
    19 A; 19 6.54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10181566..10185188)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10204202..10207824)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein 3 pseudogene Neighboring gene fatty acid desaturase 1 Neighboring gene microRNA 6993 Neighboring gene STARR-positive B cell enhancer ABC_E11020 Neighboring gene flap structure specific endonuclease 1 Neighboring gene myelin regulatory factor Neighboring gene diacylglycerol lipase, alpha Neighboring gene STARR-seq mESC enhancer starr_45549 Neighboring gene predicted gene, 30042

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure and transcription promoter activity of mouse flap endonuclease 1 gene: alternative splicing and bidirectional promoter. Emoto M, et al. Gene, 2005 Aug 29. PMID 15967598
    2. TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation. Graham DB, et al. Cell Rep, 2016 Dec 13. PMID 27974209, Free PMC Article
    3. Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Ramírez AS, et al. Science, 2019 Dec 13. PMID 31831667
    4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oligosaccharyltransferase complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within epithelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oligosaccharyltransferase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 258
    Names
    UPF0197 transmembrane protein C11orf10 homolog
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258
    oligosaccharyl transferase subunit TMEM258

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163431.1 → NP_001156903.1  transmembrane protein 258 isoform 2

      See identical proteins and their annotated locations for NP_001156903.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC132148, AV456553, BC058335
      Consensus CDS
      CCDS50386.1
      UniProtKB/TrEMBL
      E9Q853
      Related
      ENSMUSP00000128883.2, ENSMUST00000166412.2
      Conserved Domains (1) summary
      pfam05251
      Location:2 → 74
      Ost5; Oligosaccharyltransferase subunit 5

    2. NM_026919.1 → NP_081195.1  transmembrane protein 258 isoform 1

      See identical proteins and their annotated locations for NP_081195.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK007351, AV456553, BB568308
      Consensus CDS
      CCDS50385.1
      UniProtKB/Swiss-Prot
      P61166
      UniProtKB/TrEMBL
      Q60FD1
      Related
      ENSMUSP00000044751.8, ENSMUST00000040372.14
      Conserved Domains (1) summary
      pfam05251
      Location:7 → 79
      Ost5; Oligosaccharyltransferase subunit 5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10181566..10185188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61166.1 GenPept UniProtKB/Swiss-Prot:P61166

    Gene LinkOut

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