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    LINC01128 long intergenic non-protein coding RNA 1128 [ Homo sapiens (human) ]

    Gene ID: 643837, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC01128provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1128provided by HGNC
    Primary source
    HGNC:HGNC:49377
    See related
    Ensembl:ENSG00000228794 AllianceGenome:HGNC:49377
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in heart (RPKM 8.4), fat (RPKM 5.1) and 25 other tissues See more
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    Genomic context

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    See LINC01128 in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (827591..859446)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (256563..288416)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (762971..794826)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2 Neighboring gene family with sequence similarity 87 member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1 Neighboring gene long intergenic non-protein coding RNA 115 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:772694-772873 Neighboring gene uncharacterized LOC107984850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:802261-802760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2 Neighboring gene family with sequence similarity 41 member C Neighboring gene tubulin beta 8 class VIII pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LINC01128 facilitates the progression of pancreatic cancer through up-regulation of LDHA by targeting miR-561-5p. Zhong M, et al. Cancer Cell Int, 2022 Feb 22. PMID 35193567, Free PMC Article
    2. LINC01128 - miR-16 interaction regulates the migration and invasion of human chorionic trophoblast cells. Zhao X, et al. Hypertens Pregnancy, 2021 May. PMID 33881945
    3. Upregulated lncRNA LINC01128 in colorectal cancer accelerates cell growth and predicts malignant prognosis through sponging miR-363-3p. Zhou X, et al. J Cancer Res Clin Oncol, 2024 May 26. PMID 38796816, Free PMC Article
    4. ARID5B-mediated LINC01128 epigenetically activated pyroptosis and apoptosis by promoting the formation of the BTF3/STAT3 complex in β2GPI/anti-β2GPI-treated monocytes. Tan Y, et al. Clin Transl Med, 2024 Jan. PMID 38224186, Free PMC Article
    5. Long non-coding RNA LINC01128 affects proliferation, migration, and invasion of glioma cells by regulating miR-27b-3p. Zhang Q, et al. Folia Neuropathol, 2022. PMID 36382487

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulated lncRNA LINC01128 in colorectal cancer accelerates cell growth and predicts malignant prognosis through sponging miR-363-3p.
      Title: Upregulated lncRNA LINC01128 in colorectal cancer accelerates cell growth and predicts malignant prognosis through sponging miR-363-3p.
    2. ARID5B-mediated LINC01128 epigenetically activated pyroptosis and apoptosis by promoting the formation of the BTF3/STAT3 complex in beta2GPI/anti-beta2GPI-treated monocytes.
      Title: ARID5B-mediated LINC01128 epigenetically activated pyroptosis and apoptosis by promoting the formation of the BTF3/STAT3 complex in β2GPI/anti-β2GPI-treated monocytes.
    3. Long non-coding RNA LINC01128 affects proliferation, migration, and invasion of glioma cells by regulating miR-27b-3p.
      Title: Long non-coding RNA LINC01128 affects proliferation, migration, and invasion of glioma cells by regulating miR-27b-3p.
    4. LINC01128 - miR-16 interaction regulates the migration and invasion of human chorionic trophoblast cells.
      Title: LINC01128 - miR-16 interaction regulates the migration and invasion of human chorionic trophoblast cells.
    5. LINC01128 regulates the development of osteosarcoma by sponging miR-299-3p to mediate MMP2 expression and activating Wnt/beta-catenin signalling pathway.
      Title: LINC01128 regulates the development of osteosarcoma by sponging miR-299-3p to mediate MMP2 expression and activating Wnt/β-catenin signalling pathway.
    6. Long intergenic non-protein coding RNA 1128 (LINC01128) displays high expression in cervical cancer (CC) tissues. LINC01128 shortage reduces the expression of stratifin (SFN) at mRNA and protein levels. LINC01128 enhances cell proliferation, migration and invasion as well as inhibits cell apoptosis by binding with miR-383-5p and upregulating SFN.
      Title: LINC01128 expedites cervical cancer progression by regulating miR-383-5p/SFN axis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • RP11-206L10.11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_047519.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AL669831, BC102012, CN361275, DR005973

    2. NR_047521.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon compared to variant 1.
      Source sequence(s)
      AL669831, BC042880, CN361275
      Related
      ENST00000445118.7

    3. NR_047523.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two internal exons compared to variant 1.
      Source sequence(s)
      AL669831, CN361275, DA780029

    4. NR_047524.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks two consecutive internal exons compared to variant 1.
      Source sequence(s)
      AL669831, BC107481, CN361275

    5. NR_047525.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate 5'-most exon and lacks an internal exon, compared to variant 1.
      Source sequence(s)
      AL669831, DA223705

    6. NR_047526.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks a large portion of the 3' region and uses an alternate terminal exon, compared to variant 1.
      Source sequence(s)
      AI051839, AL669831, BX095144, CN361275

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      827591..859446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      256563..288416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_015368.2: Suppressed sequence

      Description
      NR_015368.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

    2. NR_047520.1: Suppressed sequence

      Description
      NR_047520.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

    3. NR_047522.1: Suppressed sequence

      Description
      NR_047522.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version

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