PGR progesterone receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: PGRprovided by HGNC
Official Full Name: progesterone receptorprovided by HGNC
Primary source: HGNC:HGNC:8910
See related: Ensembl:ENSG00000082175 MIM:607311; AllianceGenome:HGNC:8910
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PR; NR3C3
Summary: This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
Expression: Biased expression in endometrium (RPKM 46.4) and ovary (RPKM 5.5) See more
Orthologs: mouse all
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Genomic context

Location:: 11q22.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (101029624..101129813, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (101039187..101139328, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (100900355..101000544, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Progesterone receptor distribution in the human hypothalamus and its association with suicide.
Title: Progesterone receptor distribution in the human hypothalamus and its association with suicide.
Progesterone and cAMP synergistically induce SHP2 expression via PGR and CREB1 during uterine stromal decidualization.
Title: Progesterone and cAMP synergistically induce SHP2 expression via PGR and CREB1 during uterine stromal decidualization.
USP7 promotes decidualization of ESCs by STAT3/PR axis during early pregnancy.
Title: USP7 promotes decidualization of ESCs by STAT3/PR axis during early pregnancy.
The role of progesterone receptor isoforms in the myometrium.
Title: The role of progesterone receptor isoforms in the myometrium.
Progesterone receptor expression and prediction of benefits of adjuvant radiotherapy in de novo atypical meningiomas after gross-total resection.
Title: Progesterone receptor expression and prediction of benefits of adjuvant radiotherapy in de novo atypical meningiomas after gross-total resection.
Association of Val660Leu, progesterone receptor polymorphic variant, with susceptibility to RRMS disease.
Title: Association of Val660Leu, progesterone receptor polymorphic variant, with susceptibility to RRMS disease.
Malignancy risk factors and prognostic variables of pancreatic mucinous cystic neoplasms in Chinese patients.
Title: Malignancy risk factors and prognostic variables of pancreatic mucinous cystic neoplasms in Chinese patients.
PRB inhibited cell proliferation through let-7b-E2F1 in breast cancer.
Title: PRB inhibited cell proliferation through let-7b-E2F1 in breast cancer.
A prospective cohort study of clinical characteristics and outcomes in Chinese patients with estrogen receptor-negative/progesterone receptor-positive early breast cancer.
Title: A prospective cohort study of clinical characteristics and outcomes in Chinese patients with estrogen receptor-negative/progesterone receptor-positive early breast cancer.
Interferon-gamma is quintessential for NOS2 and COX2 expression in ER[-] breast tumors that lead to poor outcome.
Title: Interferon-gamma is quintessential for NOS2 and COX2 expression in ER(-) breast tumors that lead to poor outcome.

Submit: New GeneRIF Correction See all GeneRIFs (645)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Progesterone resistance MedGen: C1849699 OMIM: 264080 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:197856 (e-PCR)
- UniSTS:155971

PGR (e-PCR)
- UniSTS:66636

G67471 (e-PCR)
- UniSTS:186724

G67472 (e-PCR)
- UniSTS:186725

G67473 (e-PCR)
- UniSTS:186726

G67474 (e-PCR)
- UniSTS:186727

G67475 (e-PCR)
- UniSTS:186728

NoName (e-PCR)
- UniSTS:494788

STS-X51730 (e-PCR)
- UniSTS:80081

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATPase binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables G protein-coupled receptor activity	IC Inferred by Curator more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in glandular epithelial cell maturation	IEA Inferred from Electronic Annotation more info
involved_in lung alveolus development	IEA Inferred from Electronic Annotation more info
involved_in maintenance of protein location in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IEP Inferred from Expression Pattern more info	PubMed
involved_in nuclear receptor-mediated steroid hormone signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ovulation from ovarian follicle	IEA Inferred from Electronic Annotation more info
involved_in paracrine signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in progesterone receptor signaling pathway	IC Inferred by Curator more info	PubMed
involved_in progesterone receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in progesterone receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	EXP Inferred from Experiment more info	PubMed
involved_in regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in tertiary branching involved in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: progesterone receptor

Names: nuclear receptor subfamily 3 group C member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016475.1 RefSeqGene

Range

5001..105190

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000926.4 → NP_000917.3 progesterone receptor isoform B

See identical proteins and their annotated locations for NP_000917.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (B).

Source sequence(s)

AP001533, M15716

Consensus CDS

CCDS8310.1

UniProtKB/Swiss-Prot

A7LQ08, A7X8B0, B4E3T0, P06401, Q8TDS3, Q9UPF7

UniProtKB/TrEMBL

Q8NG42

Related

ENSP00000325120.5, ENST00000325455.10

Conserved Domains (3) summary

cd07074
Location:686 → 933

NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor

cd07172
Location:563 → 640

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02161
Location:1 → 564

Prog_receptor; Progesterone receptor
NM_001202474.3 → NP_001189403.1 progesterone receptor isoform A

Status: REVIEWED

Source sequence(s)

AP001533, M15716

UniProtKB/Swiss-Prot

P06401

Conserved Domains (3) summary

cd07074
Location:522 → 769

NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor

cd07172
Location:399 → 476

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02161
Location:1 → 400

Prog_receptor; Progesterone receptor
NM_001271161.2 → NP_001258090.1 progesterone receptor isoform C

Status: REVIEWED

Source sequence(s)

AB084248, AP001533

UniProtKB/Swiss-Prot

P06401

Related

ENSP00000263463.5, ENST00000263463.9

Conserved Domains (3) summary

cd07172
Location:399 → 475

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02161
Location:1 → 400

Prog_receptor; Progesterone receptor

cl11397
Location:470 → 667

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001271162.2 → NP_001258091.1 progesterone receptor isoform D

See identical proteins and their annotated locations for NP_001258091.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) represents an alternate first exon, compared to variant 1, resulting in a protein isoform (D) with a shorter N-terminus.

Source sequence(s)

AK304853, AP001533

Consensus CDS

CCDS59229.1

UniProtKB/Swiss-Prot

P06401

Related

ENSP00000436561.1, ENST00000534013.5

Conserved Domains (2) summary

cd07074
Location:92 → 339

NR_LBD_PR; Ligand binding domain of the progesterone receptor, a member of the nuclear hormone receptor

cl02596
Location:1 → 46

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

RNA

NR_073141.3 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon and represents use of an alternate splice acceptor site, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.

Source sequence(s)

AB085845, AP001533
NR_073142.3 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) represents use of an alternate splice acceptor site, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.

Source sequence(s)

AB085843, AP001533
NR_073143.3 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) omits two coding exons, compared to variant 1, which results in a premature stop codon. This variant is represented as non-coding because it is a nonsense-mediated decay (NMD) candidate.

Source sequence(s)

AB085683, AP001533

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

101029624..101129813 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006718858.4 → XP_006718921.1 progesterone receptor isoform X1

UniProtKB/TrEMBL

Q8NG42

Related

ENSP00000432352.1, ENST00000534780.5

Conserved Domains (3) summary

cd07172
Location:563 → 640

NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

pfam02161
Location:1 → 564

Prog_receptor; Progesterone receptor

cl11397
Location:686 → 786

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
XM_011542869.3 → XP_011541171.1 progesterone receptor isoform X2

UniProtKB/TrEMBL

Q8NG43

Conserved Domains (2) summary

pfam02161
Location:1 → 564

Prog_receptor; Progesterone receptor

cl02596
Location:563 → 596

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers