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    RACGAP1P1 Rac GTPase activating protein 1 pseudogene 1 [ Homo sapiens (human) ]

    Gene ID: 83956, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RACGAP1P1provided by HGNC
    Official Full Name
    Rac GTPase activating protein 1 pseudogene 1provided by HGNC
    Primary source
    HGNC:HGNC:24689
    See related
    AllianceGenome:HGNC:24689
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FKSG42; RACGAP1P
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    Genomic context

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    See RACGAP1P1 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (45062618..45065411, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (45021251..45024044, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (45456401..45459194, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene neural EGFL like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:45270221-45270722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:45270723-45271222 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6224 Neighboring gene uncharacterized LOC105369742 Neighboring gene developing brain homeobox 2 Neighboring gene DBX2 antisense RNA 1 Neighboring gene small RNA binding exonuclease protection factor La like 3, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 361

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pseudogene RACGAP1P activates RACGAP1/Rho/ERK signalling axis as a competing endogenous RNA to promote hepatocellular carcinoma early recurrence. Wang MY, et al. Cell Death Dis, 2019 Jun 3. PMID 31160556, Free PMC Article
    2. Long non-coding RNA RACGAP1P promotes breast cancer invasion and metastasis via miR-345-5p/RACGAP1-mediated mitochondrial fission. Zhou D, et al. Mol Oncol, 2021 Feb. PMID 33252198, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA RACGAP1P promotes breast cancer invasion and metastasis via miR-345-5p/RACGAP1-mediated mitochondrial fission.
      Title: Long non-coding RNA RACGAP1P promotes breast cancer invasion and metastasis via miR-345-5p/RACGAP1-mediated mitochondrial fission.
    2. Mechanistic investigations indicated that RACGAP1P elicits its oncogenic activity as a competitive endogenous RNA to sequestrate miR-15-5p from its endogenous target RACGAP1, thereby leading to the upregulation of RACGAP1 and the activation of RhoA/ERK signalling.
      Title: Pseudogene RACGAP1P activates RACGAP1/Rho/ERK signalling axis as a competing endogenous RNA to promote hepatocellular carcinoma early recurrence.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026583.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008127

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      45062618..45065411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      45021251..45024044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_005045.4: Suppressed sequence

      Description
      NG_005045.4: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.

    2. NM_032032.1: Suppressed sequence

      Description
      NM_032032.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version

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