CEND1 cell cycle exit and neuronal differentiation 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CEND1provided by HGNC
Official Full Name: cell cycle exit and neuronal differentiation 1provided by HGNC
Primary source: HGNC:HGNC:24153
See related: Ensembl:ENSG00000184524 MIM:608213; AllianceGenome:HGNC:24153
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BM88
Summary: The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 37.5) and adrenal (RPKM 2.6) See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (787115..790090, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (838549..841523, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (787115..790090, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons.
Title: Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons.
CEND1 and miR885 methylation changes associated with successful cognitive aging in community-dwelling older adults.
Title: CEND1 and miR885 methylation changes associated with successful cognitive aging in community-dwelling older adults.
Interaction of CEND1 gene and life events in susceptibility to depressive symptoms in Chinese Han college students.
Title: Interaction of CEND1 gene and life events in susceptibility to depressive symptoms in Chinese Han college students.
BM88/Cend1 participates in cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis and becomes crucial for the transition from neuroblasts to mature neurons when reaching high levels
Title: BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12688 (e-PCR)
- UniSTS:8757

RH102018 (e-PCR)
- UniSTS:96352

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adult walking behavior	IEA Inferred from Electronic Annotation more info
involved_in cerebellar Purkinje cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebellar granular layer maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cerebellar granule cell precursor proliferation	IEA Inferred from Electronic Annotation more info
involved_in radial glia guided migration of cerebellar granule cell	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with mitochondrion	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cell cycle exit and neuronal differentiation protein 1

Names: BM88 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016564.4 → NP_057648.2 cell cycle exit and neuronal differentiation protein 1

See identical proteins and their annotated locations for NP_057648.2

Status: REVIEWED

Source sequence(s)

AP006621, DA066200

Consensus CDS

CCDS7714.1

UniProtKB/Swiss-Prot

Q8N111, Q9NYM6

UniProtKB/TrEMBL

B2R7I3

Related

ENSP00000328336.4, ENST00000330106.5

Conserved Domains (1) summary

pfam15677
Location:1 → 149

CEND1; Cell cycle exit and neuronal differentiation protein 1