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    USP36 ubiquitin specific peptidase 36 [ Homo sapiens (human) ]

    Gene ID: 57602, updated on 10-Dec-2024

    Summary

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    Official Symbol
    USP36provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 36provided by HGNC
    Primary source
    HGNC:HGNC:20062
    See related
    Ensembl:ENSG00000055483 MIM:612543; AllianceGenome:HGNC:20062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DUB1
    Summary
    This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in bone marrow (RPKM 11.2), adrenal (RPKM 8.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See USP36 in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (78787381..78841439, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (79682181..79736241, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76783463..76837521, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904066 Neighboring gene MPRA-validated peak3019 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76662364-76662975 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76662976-76663586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76663587-76664197 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:76664198-76664807 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76671141-76672019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76672283-76672784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76672785-76673284 Neighboring gene cytohesin 1 Neighboring gene RNA, U6 small nuclear 638, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12903 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:76719667-76720172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12905 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12909 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76770651-76771152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9073 Neighboring gene CRISPRi-validated cis-regulatory element chr17.5512 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76834350-76834864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:76834865-76835379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12913 Neighboring gene uncharacterized LOC124904067 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9075 Neighboring gene MPRA-validated peak3020 silencer Neighboring gene uncharacterized LOC124904068 Neighboring gene Sharpr-MPRA regulatory region 3779 Neighboring gene MPRA-validated peak3021 silencer Neighboring gene ribosomal protein L9 pseudogene 29 Neighboring gene TIMP metallopeptidase inhibitor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential display identifies overexpression of the USP36 gene, encoding a deubiquitinating enzyme, in ovarian cancer. Li J, et al. Int J Med Sci, 2008 Jun 6. PMID 18566677, Free PMC Article
    2. USP36 regulates the proliferation, survival, and differentiation of hFOB1.19 osteoblast. Yan J, et al. J Orthop Surg Res, 2024 Aug 17. PMID 39152465, Free PMC Article
    3. Deubiquitinating enzyme USP36 contains the PEST motif and is polyubiquitinated. Kim MS, et al. Biochem Biophys Res Commun, 2005 May 13. PMID 15809067
    4. A novel cysteine protease HeLa DUB-1 responsible for cleaving the ubiquitin in human ovarian cancer cells. Kim MS, et al. Int J Oncol, 2004 Aug. PMID 15254734
    5. Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer. Guan S, et al. Clin Cancer Res, 2024 Apr 1. PMID 38261467

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP36 SUMOylates Las1L and Promotes Its Function in Pre-Ribosomal RNA ITS2 Processing.
      Title: USP36 SUMOylates Las1L and Promotes Its Function in Pre-Ribosomal RNA ITS2 Processing.
    2. USP36 promotes tumorigenesis and tamoxifen resistance in breast cancer by deubiquitinating and stabilizing ERalpha.
      Title: USP36 promotes tumorigenesis and tamoxifen resistance in breast cancer by deubiquitinating and stabilizing ERα.
    3. USP36 regulates the proliferation, survival, and differentiation of hFOB1.19 osteoblast.
      Title: USP36 regulates the proliferation, survival, and differentiation of hFOB1.19 osteoblast.
    4. USP36 inhibits apoptosis by deubiquitinating cIAP1 and survivin in colorectal cancer cells.
      Title: USP36 inhibits apoptosis by deubiquitinating cIAP1 and survivin in colorectal cancer cells.
    5. Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
      Title: Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
    6. USP36 plays an oncogenic role in colorectal cancer cells.
      Title: USP36 plays an oncogenic role in colorectal cancer cells.
    7. The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8.
      Title: The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8.
    8. The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.
      Title: The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.
    9. USP36 facilitates esophageal squamous carcinoma progression via stabilizing YAP.
      Title: USP36 facilitates esophageal squamous carcinoma progression via stabilizing YAP.
    10. CircRNA circUSP36 impairs the stability of NEDD4L mRNA through recruiting PTBP1 to enhance ULK1-mediated autophagic granulosa cell death.
      Title: CircRNA circUSP36 impairs the stability of NEDD4L mRNA through recruiting PTBP1 to enhance ULK1-mediated autophagic granulosa cell death.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2B deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleolus organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitophagy HMP PubMed 
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of rRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 36
    Names
    deubiquitinating enzyme 36
    ubiquitin specific protease 36
    ubiquitin thioesterase 36
    ubiquitin-specific-processing protease 36
    NP_001308220.1
    NP_001372098.1
    NP_001372099.1
    NP_001372100.1
    NP_001372101.1
    NP_001372102.1
    NP_001372103.1
    NP_001372104.1
    NP_001372105.1
    NP_001372106.1
    NP_001372107.1
    NP_001372108.1
    NP_001372109.1
    XP_011523367.1
    XP_011523368.1
    XP_011523370.1
    XP_011523371.1
    XP_011523373.1
    XP_016880390.1
    XP_024306613.1
    XP_024306614.1
    XP_047292424.1
    XP_047292425.1
    XP_047292426.1
    XP_047292427.1
    XP_047292428.1
    XP_047292429.1
    XP_047292430.1
    XP_047292431.1
    XP_047292432.1
    XP_054172735.1
    XP_054172736.1
    XP_054172737.1
    XP_054172738.1
    XP_054172739.1
    XP_054172740.1
    XP_054172741.1
    XP_054172742.1
    XP_054172743.1
    XP_054172744.1
    XP_054172745.1
    XP_054172746.1
    XP_054172747.1
    XP_054172748.1
    XP_054172749.1
    XP_054172750.1
    XP_054172751.1
    XP_054172752.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321291.2 → NP_001308220.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 3-9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Related
      ENSP00000441214.1, ENST00000542802.7
      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    2. NM_001385169.1 → NP_001372098.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC022966
      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    3. NM_001385170.1 → NP_001372099.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 2 and 4-9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    4. NM_001385171.1 → NP_001372100.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 2, 3, and 5-9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    5. NM_001385172.1 → NP_001372101.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 2-4 and 6-9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    6. NM_001385173.1 → NP_001372102.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 2-5 and 7-9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    7. NM_001385174.1 → NP_001372103.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 2-6, 8, and 9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Related
      ENSP00000401119.4, ENST00000449938.7
      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    8. NM_001385175.1 → NP_001372104.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 2-7 and 9, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Related
      ENSP00000465698.2, ENST00000592231.6
      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    9. NM_001385176.1 → NP_001372105.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 2-8, encodes isoform 2.
      Source sequence(s)
      AC022966
      Consensus CDS
      CCDS32755.1
      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275
      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    10. NM_001385177.1 → NP_001372106.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 11, encodes isoform 3.
      Source sequence(s)
      AC022966
      Conserved Domains (2) summary
      PHA03247
      Location:341 → 675
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:1 → 256
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    11. NM_001385178.1 → NP_001372107.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 10, encodes isoform 3.
      Source sequence(s)
      AC022966
      Conserved Domains (2) summary
      PHA03247
      Location:341 → 675
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:1 → 256
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    12. NM_001385179.1 → NP_001372108.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC022966
      Conserved Domains (2) summary
      PHA03247
      Location:296 → 630
      PHA03247; large tegument protein UL36; Provisional
      cl02553
      Location:21 → 211
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    13. NM_001385180.1 → NP_001372109.1  ubiquitin carboxyl-terminal hydrolase 36 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022966
      UniProtKB/TrEMBL
      B3KMW2
      Conserved Domains (2) summary
      PHA03247
      Location:287 → 621
      PHA03247; large tegument protein UL36; Provisional
      cl02553
      Location:1 → 202
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    RNA

    1. NR_169581.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022966

    2. NR_169582.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022966

    3. NR_169583.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022966

    4. NR_169584.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022966

    5. NR_169585.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC022966
      Related
      ENST00000693020.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      78787381..78841439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525071.4 → XP_011523373.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X10

      Conserved Domains (2) summary
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:122 → 420
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. XM_011525069.4 → XP_011523371.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X7

      Conserved Domains (2) summary
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:122 → 420
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. XM_011525066.4 → XP_011523368.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

      See identical proteins and their annotated locations for XP_011523368.1

      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    4. XM_011525065.3 → XP_011523367.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

      See identical proteins and their annotated locations for XP_011523367.1

      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    5. XM_047436472.1 → XP_047292428.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X5

    6. XM_047436470.1 → XP_047292426.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275

    7. XM_047436469.1 → XP_047292425.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

      UniProtKB/Swiss-Prot
      Q05C98, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8, Q9P275

    8. XM_024450845.2 → XP_024306613.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    9. XM_024450846.2 → XP_024306614.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:506 → 840
      PHA03247; large tegument protein UL36; Provisional
      cd02661
      Location:121 → 421
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

    10. XM_047436468.1 → XP_047292424.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    11. XM_011525068.2 → XP_011523370.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

      Conserved Domains (2) summary
      cd02661
      Location:1 → 256
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1 → 255
      UCH; Ubiquitin carboxyl-terminal hydrolase

    12. XM_017024901.2 → XP_016880390.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X4

    13. XM_047436473.1 → XP_047292429.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

    14. XM_047436474.1 → XP_047292430.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X8

    15. XM_047436475.1 → XP_047292431.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X9

    16. XM_047436471.1 → XP_047292427.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X3

    17. XM_047436476.1 → XP_047292432.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X11

      UniProtKB/TrEMBL
      A0A075B784
      Related
      ENSP00000468549.3, ENST00000588086.6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      79682181..79736241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316776.1 → XP_054172751.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X10

    2. XM_054316773.1 → XP_054172748.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X7

    3. XM_054316766.1 → XP_054172741.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    4. XM_054316761.1 → XP_054172736.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    5. XM_054316760.1 → XP_054172735.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    6. XM_054316770.1 → XP_054172745.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X5

    7. XM_054316762.1 → XP_054172737.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    8. XM_054316767.1 → XP_054172742.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    9. XM_054316765.1 → XP_054172740.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    10. XM_054316763.1 → XP_054172738.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    11. XM_054316764.1 → XP_054172739.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    12. XM_054316772.1 → XP_054172747.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

    13. XM_054316769.1 → XP_054172744.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X4

    14. XM_054316771.1 → XP_054172746.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

    15. XM_054316774.1 → XP_054172749.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X8

    16. XM_054316775.1 → XP_054172750.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X9

    17. XM_054316768.1 → XP_054172743.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X3

    18. XM_054316777.1 → XP_054172752.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X11

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025090.3: Suppressed sequence

      Description
      NM_025090.3: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P275.4 GenPept UniProtKB/Swiss-Prot:Q9P275

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