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    CXXC5 CXXC finger protein 5 [ Homo sapiens (human) ]

    Gene ID: 51523, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CXXC5provided by HGNC
    Official Full Name
    CXXC finger protein 5provided by HGNC
    Primary source
    HGNC:HGNC:26943
    See related
    Ensembl:ENSG00000171604 MIM:612752; AllianceGenome:HGNC:26943
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CF5; WID; RINF; HSPC195
    Summary
    The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in brain (RPKM 19.6), kidney (RPKM 19.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CXXC5 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139647299..139683882)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (140172362..140208961)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139026884..139063467)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 D2 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 15 Neighboring gene Sharpr-MPRA regulatory region 3558 Neighboring gene CRISPRi-validated cis-regulatory element chr5.3240 Neighboring gene Sharpr-MPRA regulatory region 4362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139017982-139018548 Neighboring gene H3 histone pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139030154-139030654 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23247 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139038513-139039362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139040914-139041480 Neighboring gene CXXC5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23248 Neighboring gene uncharacterized LOC124901084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139053795-139054348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139058359-139059081 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139064529-139065183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16425 Neighboring gene Sharpr-MPRA regulatory region 3182 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139077525-139078494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139079969-139080794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139080795-139081619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139088825-139089815 Neighboring gene uncharacterized LOC124901085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139104350-139104850 Neighboring gene RNA, U6 small nuclear 236, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139117735-139118662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139121544-139122093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139122094-139122642 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:139123561-139124154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:139125678-139126325 Neighboring gene PSD2 antisense RNA 1 Neighboring gene pleckstrin and Sec7 domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RINF (CXXC5) is overexpressed in solid tumors and is an unfavorable prognostic factor in breast cancer. Knappskog S, et al. Ann Oncol, 2011 Oct. PMID 21325450
    2. Estradiol-Estrogen Receptor α Mediates the Expression of the CXXC5 Gene through the Estrogen Response Element-Dependent Signaling Pathway. Yaşar P, et al. Sci Rep, 2016 Nov 25. PMID 27886276, Free PMC Article
    3. Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia. Kühnl A, et al. Blood, 2015 May 7. PMID 25805812, Free PMC Article
    4. Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation. Bruserud Ø, et al. Oncotarget, 2015 Feb 20. PMID 25605239, Free PMC Article
    5. CXXC5 regulates differentiation of C2C12 myoblasts into myocytes. Li G, et al. J Muscle Res Cell Motil, 2014 Dec. PMID 25433557

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CXXC5 drove inflammation and ovarian cancer proliferation via transcriptional activation of ZNF143 and EGR1.
      Title: CXXC5 drove inflammation and ovarian cancer proliferation via transcriptional activation of ZNF143 and EGR1.
    2. Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair.
      Title: Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair.
    3. Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/beta-catenin signaling pathway.
      Title: Inhibition of CXXC5 function rescues Alzheimer's disease phenotypes by restoring Wnt/β-catenin signaling pathway.
    4. CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2.
      Title: CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD(2).
    5. Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1/mTOR signaling pathway.
      Title: Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1/mTOR signaling pathway.
    6. Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5.
      Title: Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5.
    7. Inhibition of CXXC5 function reverses obesity-related metabolic diseases.
      Title: Inhibition of CXXC5 function reverses obesity-related metabolic diseases.
    8. A prelude to the proximity interaction mapping of CXXC5.
      Title: A prelude to the proximity interaction mapping of CXXC5.
    9. The epigenetic regulator RINF (CXXC5) maintains <i>SMAD7</i> expression in human immature erythroid cells and sustains red blood cells expansion.
      Title: The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cells expansion.
    10. CXXC5 is direct target gene of miR-32 which binds its 3'-UTR and inhibited the expression level of CXXC5 mRNA and protein.
      Title: miR-32 promotes esophageal squamous cell carcinoma metastasis by targeting CXXC5.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl-CpG binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction HMP PubMed 
    involved_in regulation of generation of precursor metabolites and energy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CXXC-type zinc finger protein 5
    Names
    CXXC finger 5 protein
    WT1-induced Inhibitor of Dishevelled
    putative MAPK-activating protein PM08
    putative NF-kappa-B-activating protein 102
    retinoid-inducible nuclear factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317199.2 → NP_001304128.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All of the variants encode the same protein.
      Source sequence(s)
      AK024338, BC006428, DA291558
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    2. NM_001317200.2 → NP_001304129.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AK001782, BC006428
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Related
      ENSP00000427379.1, ENST00000511048.1
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    3. NM_001317201.2 → NP_001304130.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, DA705695
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    4. NM_001317202.2 → NP_001304131.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, DA264868
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    5. NM_001317203.2 → NP_001304132.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AC113361, BC006428, BI763590, DA031665
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    6. NM_001317204.2 → NP_001304133.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AC113361, BC006428, DA031665
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    7. NM_001317205.2 → NP_001304134.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, DA170918
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    8. NM_001317206.2 → NP_001304135.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, CB140368, HY181287
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    9. NM_001317207.2 → NP_001304136.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, CB140368
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    10. NM_001317208.2 → NP_001304137.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, DB458723
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    11. NM_001317209.2 → NP_001304138.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, BI460400, HY012710
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    12. NM_001317210.2 → NP_001304139.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, BI460400, HY043636
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    13. NM_001317211.2 → NP_001304140.1  CXXC-type zinc finger protein 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      BC006428, BI460400, HY015270
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    14. NM_016463.9 → NP_057547.5  CXXC-type zinc finger protein 5

      See identical proteins and their annotated locations for NP_057547.5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AK024338, BC006428
      Consensus CDS
      CCDS43370.1
      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
      Related
      ENSP00000302543.3, ENST00000302517.8
      Conserved Domains (1) summary
      pfam02008
      Location:255 → 296
      zf-CXXC; CXXC zinc finger domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      139647299..139683882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417302.1 → XP_047273258.1  CXXC-type zinc finger protein 5 isoform X1

      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      140172362..140208961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352807.1 → XP_054208782.1  CXXC-type zinc finger protein 5 isoform X1

      UniProtKB/Swiss-Prot
      B3KND0, C8CBA8, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7LFL8.1 GenPept UniProtKB/Swiss-Prot:Q7LFL8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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