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    TMEM61 transmembrane protein 61 [ Homo sapiens (human) ]

    Gene ID: 199964, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TMEM61provided by HGNC
    Official Full Name
    transmembrane protein 61provided by HGNC
    Primary source
    HGNC:HGNC:27296
    See related
    Ensembl:ENSG00000143001 AllianceGenome:HGNC:27296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney (RPKM 2.5), salivary gland (RPKM 2.4) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM61 in Genome Data Viewer
    Location:
    1p32.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (54980628..54992288)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (54860835..54872524)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55446301..55457961)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904184 Neighboring gene tRNA-Lys (anticodon CTT) 7-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1069 Neighboring gene uncharacterized LOC105378736 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55462851-55463835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55466287-55466787 Neighboring gene barttin CLCNK type accessory subunit beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55484247-55484747 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:55488329-55488955 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:55493259-55493762 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:55493763-55494266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55494267-55494770 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:55501658-55501847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55509121-55509622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55509623-55510122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55514655-55515210 Neighboring gene proprotein convertase subtilisin/kexin type 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Proteome-scale mapping of binding sites in the unstructured regions of the human proteome. Benz C, et al. Mol Syst Biol, 2022 Jan. PMID 35044719, Free PMC Article
    2. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
    3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
    4. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182532.3 → NP_872338.1  transmembrane protein 61

      See identical proteins and their annotated locations for NP_872338.1

      Status: VALIDATED

      Source sequence(s)
      AA918832, AL590440, BC029775, BG430102
      Consensus CDS
      CCDS601.1
      UniProtKB/Swiss-Prot
      Q8N0U2
      Related
      ENSP00000360315.3, ENST00000371268.4
      Conserved Domains (1) summary
      pfam15105
      Location:13 → 206
      TMEM61; TMEM61 protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      54980628..54992288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540911.3 → XP_011539213.1  transmembrane protein 61 isoform X1

      See identical proteins and their annotated locations for XP_011539213.1

      UniProtKB/Swiss-Prot
      Q8N0U2
      Related
      ENSP00000520542.1, ENST00000715913.1
      Conserved Domains (1) summary
      pfam15105
      Location:13 → 206
      TMEM61; TMEM61 protein family

    2. XM_005270586.5 → XP_005270643.1  transmembrane protein 61 isoform X2

      See identical proteins and their annotated locations for XP_005270643.1

      UniProtKB/TrEMBL
      A0AAQ5BIH8
      Related
      ENSP00000520540.1, ENST00000715911.1
      Conserved Domains (1) summary
      pfam15105
      Location:8 → 201
      TMEM61; TMEM61 protein family

    3. XM_011540912.3 → XP_011539214.1  transmembrane protein 61 isoform X2

      See identical proteins and their annotated locations for XP_011539214.1

      UniProtKB/TrEMBL
      A0AAQ5BIH8
      Conserved Domains (1) summary
      pfam15105
      Location:8 → 201
      TMEM61; TMEM61 protein family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      54860835..54872524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334900.1 → XP_054190875.1  transmembrane protein 61 isoform X1

      UniProtKB/Swiss-Prot
      Q8N0U2

    2. XM_054334901.1 → XP_054190876.1  transmembrane protein 61 isoform X2

      UniProtKB/TrEMBL
      A0AAQ5BIH8

    3. XM_054334902.1 → XP_054190877.1  transmembrane protein 61 isoform X2

      UniProtKB/TrEMBL
      A0AAQ5BIH8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N0U2.1 GenPept UniProtKB/Swiss-Prot:Q8N0U2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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