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    SULT1C2 sulfotransferase family 1C member 2 [ Homo sapiens (human) ]

    Gene ID: 6819, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SULT1C2provided by HGNC
    Official Full Name
    sulfotransferase family 1C member 2provided by HGNC
    Primary source
    HGNC:HGNC:11456
    See related
    Ensembl:ENSG00000198203 MIM:602385; AllianceGenome:HGNC:11456
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ST1C1; ST1C2; SULT1C1; humSULTC2
    Summary
    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in stomach (RPKM 61.8), kidney (RPKM 26.2) and 3 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SULT1C2 in Genome Data Viewer
    Location:
    2q12.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (108288895..108309915)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (108749770..108770814)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (108905351..108926371)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1C member 3 Neighboring gene WASF1 pseudogene 1 Neighboring gene sulfotransferase family, cytosolic, 1C, member 2 pseudogene 2 Neighboring gene sulfotransferase family 1C member 5, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16341

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Sulfotransferase SULT1C2 Is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and Is Associated with Patient Outcome in Lung Adenocarcinoma. Johnson C, et al. Int J Environ Res Public Health, 2021 Dec 31. PMID 35010676, Free PMC Article
    2. Homodimeric and heterodimeric aryl sulfotransferases catalyze the sulfuric acid esterification of N-hydroxy-2-acetylaminofluorene. Kiehlbauch CC, et al. J Biol Chem, 1995 Aug 11. PMID 7642552
    3. Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization. Her C, et al. Genomics, 1997 May 1. PMID 9169148
    4. Molecular characterization of ST1C1-related human sulfotransferase. Yoshinari K, et al. Carcinogenesis, 1998 May. PMID 9635888
    5. Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)*. Li X, et al. Biochem Pharmacol, 2000 Dec 1. PMID 11077054

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Sulfotransferase SULT1C2 Is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and Is Associated with Patient Outcome in Lung Adenocarcinoma.
      Title: The Sulfotransferase SULT1C2 Is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and Is Associated with Patient Outcome in Lung Adenocarcinoma.
    2. Vitamin D receptor can interact directly with the SULT1C2 VDRE sequence to transcriptionally regulation SULT1C2 expression in colorectal tumor cells.
      Title: Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells.
    3. Our findings are the first to characterize the regulation of human SULT1C2 and SULT1C3 expression by several transcription factor activators.
      Title: Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by nuclear signaling pathways in LS180 colorectal adenocarcinoma cells.
    4. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.
    6. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia.
    7. gene resequencing and functional genomic studies
      Title: Human sulfotransferase SULT1C1 pharmacogenetics: gene resequencing and functional genomic studies.
    8. crystal structures of two members of SULT1 family, SULT1B1 and SULT1C1, both in complex with the product of the PAPS cofactor, adenosine-3-5-diphosphate (PAP).
      Title: Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aryl sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amine metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 1C2
    Names
    SULT1C#1
    sulfotransferase 1C1
    sulfotransferase family, cytosolic, 1C, member 1
    sulfotransferase family, cytosolic, 1C, member 2
    NP_001047.1
    NP_789795.1
    XP_005264070.1
    XP_054199546.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001056.4 → NP_001047.1  sulfotransferase 1C2 isoform a

      See identical proteins and their annotated locations for NP_001047.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and it encodes isoform a.
      Source sequence(s)
      AA856596, AC019100, AF186252
      Consensus CDS
      CCDS2075.1
      UniProtKB/Swiss-Prot
      B2R813, O00338, Q53SG4
      UniProtKB/TrEMBL
      B4DLP0
      Related
      ENSP00000251481.6, ENST00000251481.11
      Conserved Domains (1) summary
      pfam00685
      Location:39 → 288
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_176825.3 → NP_789795.1  sulfotransferase 1C2 isoform b

      See identical proteins and their annotated locations for NP_789795.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains one alternate in-frame segment and uses a different splice site in an adjacent exon when compared to variant 1. The resulting isoform (b) is longer with a different internal protein sequence when compared to isoform a.
      Source sequence(s)
      AA856596, AC019100, AF186255
      Consensus CDS
      CCDS2076.1
      UniProtKB/TrEMBL
      B4DLP0
      Related
      ENSP00000319622.5, ENST00000326853.9
      Conserved Domains (1) summary
      pfam00685
      Location:39 → 299
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      108288895..108309915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264013.5 → XP_005264070.1  sulfotransferase 1C2 isoform X1

      UniProtKB/TrEMBL
      B4DLP0
      Conserved Domains (1) summary
      pfam00685
      Location:39 → 290
      Sulfotransfer_1; Sulfotransferase domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      108749770..108770814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343571.1 → XP_054199546.1  sulfotransferase 1C2 isoform X1

      UniProtKB/TrEMBL
      B4DLP0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00338.1 GenPept UniProtKB/Swiss-Prot:O00338

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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