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    EIF4E3 eukaryotic translation initiation factor 4E family member 3 [ Homo sapiens (human) ]

    Gene ID: 317649, updated on 2-Nov-2024

    Summary

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    Official Symbol
    EIF4E3provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4E family member 3provided by HGNC
    Primary source
    HGNC:HGNC:31837
    See related
    Ensembl:ENSG00000163412 MIM:609896; AllianceGenome:HGNC:31837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    eIF-4E3; eIF4E-3
    Summary
    EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in fat (RPKM 11.9), brain (RPKM 7.2) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See EIF4E3 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (71659363..71754773, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (71698509..71794043, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71724565..71803924, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene FOXP1 divergent transcript Neighboring gene uncharacterized LOC105377155 Neighboring gene NANOG hESC enhancer GRCh37_chr3:71694238-71694747 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71752927-71753508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14522 Neighboring gene Sharpr-MPRA regulatory region 3624 Neighboring gene G protein-coupled receptor 27 Neighboring gene uncharacterized LOC105377156 Neighboring gene prokineticin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome. Weiss B, et al. Nucleic Acids Res, 2021 May 21. PMID 33893802, Free PMC Article
    2. eIF4E3, a new actor in mRNA metabolism and tumor suppression. Volpon L, et al. Cell Cycle, 2013 Apr 15. PMID 23587918, Free PMC Article
    3. Major splice variants and multiple polyadenylation site utilization in mRNAs encoding human translation initiation factors eIF4E1 and eIF4E3 regulate the translational regulators? Mrvová S, et al. Mol Genet Genomics, 2018 Feb. PMID 28942592
    4. Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules. Frydryskova K, et al. BMC Mol Biol, 2016 Aug 30. PMID 27578149, Free PMC Article
    5. eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition. Osborne MJ, et al. Proc Natl Acad Sci U S A, 2013 Mar 5. PMID 23431134, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. m7G-related genes-NCBP2 and EIF4E3 determine immune contexture in head and neck squamous cell carcinoma by regulating CCL4/CCL5 expression.
      Title: m7G-related genes-NCBP2 and EIF4E3 determine immune contexture in head and neck squamous cell carcinoma by regulating CCL4/CCL5 expression.
    2. eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome.
      Title: eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome.
    3. We performed bioinformatics analyses of ESTs and the 3'UTRs of the main transcript splice variants of the translational initiation factor eIF4E1 and its family members, eIF4E2 and eIF4E3. We propose to elucidate the minor splice variants of eIF4E2 and eIF4E3 in great detail because they might produce proteins with modified features that fulfill different cellular roles from their major counterparts.
      Title: Major splice variants and multiple polyadenylation site utilization in mRNAs encoding human translation initiation factors eIF4E1 and eIF4E3 regulate the translational regulators?
    4. Following heat shock, eIF4E2 is found in both processing bodies and stress granules, whereas eIF4E3_A relocates only to stress granules.
      Title: Distinct recruitment of human eIF4E isoforms to processing bodies and stress granules.
    5. MNK1 and MNK2 inhibition ablates eIF4E1 phosphorylation and concurrently enhances eIF4E3 expression in diffuse large B-cell lymphoma.
      Title: MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.
    6. eIF4E3 impedes oncogenic transformation and its expression is lost in some cancers.
      Title: eIF4E3, a new actor in mRNA metabolism and tumor suppression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of eukaryotic translation initiation factor 4E family member 3 (EIF4E3) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC39820, MGC86971

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E type 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134649.3 → NP_001128121.1  eukaryotic translation initiation factor 4E type 3 isoform b

      See identical proteins and their annotated locations for NP_001128121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
      Source sequence(s)
      AC096970, AC097634, BC068443, DN990553
      Consensus CDS
      CCDS33786.1
      UniProtKB/Swiss-Prot
      Q8N5X7
      Related
      ENSP00000410350.1, ENST00000448225.5
      Conserved Domains (1) summary
      pfam01652
      Location:6 → 92
      IF4E; Eukaryotic initiation factor 4E

    2. NM_001134650.1 → NP_001128122.1  eukaryotic translation initiation factor 4E type 3 isoform b

      See identical proteins and their annotated locations for NP_001128122.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
      Source sequence(s)
      AC097634, AL161983, BC068443, DA227887, DA394405
      Consensus CDS
      CCDS33786.1
      UniProtKB/Swiss-Prot
      Q8N5X7
      Related
      ENSP00000374476.3, ENST00000389826.7
      Conserved Domains (1) summary
      pfam01652
      Location:6 → 92
      IF4E; Eukaryotic initiation factor 4E

    3. NM_001134651.2 → NP_001128123.1  eukaryotic translation initiation factor 4E type 3 isoform a

      See identical proteins and their annotated locations for NP_001128123.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC097634, AC134770, AK126999, AL161983, DR159502
      Consensus CDS
      CCDS46867.1
      UniProtKB/Swiss-Prot
      B2R963, Q6NUT1, Q8N5X7
      Related
      ENSP00000393324.2, ENST00000425534.8
      Conserved Domains (1) summary
      pfam01652
      Location:48 → 198
      IF4E; Eukaryotic initiation factor 4E

    4. NM_001282886.2 → NP_001269815.1  eukaryotic translation initiation factor 4E type 3 isoform b

      See identical proteins and their annotated locations for NP_001269815.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
      Source sequence(s)
      AC096970, AC097634, BC068443
      Consensus CDS
      CCDS33786.1
      UniProtKB/Swiss-Prot
      Q8N5X7
      Related
      ENSP00000295612.3, ENST00000295612.7
      Conserved Domains (1) summary
      pfam01652
      Location:6 → 92
      IF4E; Eukaryotic initiation factor 4E

    5. NM_173359.5 → NP_775495.1  eukaryotic translation initiation factor 4E type 3 isoform b

      See identical proteins and their annotated locations for NP_775495.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2-5 encode the same isoform.
      Source sequence(s)
      AC097634, AK313656, AL161983, BC068443
      Consensus CDS
      CCDS33786.1
      UniProtKB/Swiss-Prot
      Q8N5X7
      Related
      ENSP00000411762.2, ENST00000421769.6
      Conserved Domains (1) summary
      pfam01652
      Location:6 → 92
      IF4E; Eukaryotic initiation factor 4E

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      71659363..71754773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448061.1 → XP_047304017.1  eukaryotic translation initiation factor 4E type 3 isoform X2

    2. XM_047448060.1 → XP_047304016.1  eukaryotic translation initiation factor 4E type 3 isoform X1

    3. XM_047448063.1 → XP_047304019.1  eukaryotic translation initiation factor 4E type 3 isoform X4

    4. XM_047448062.1 → XP_047304018.1  eukaryotic translation initiation factor 4E type 3 isoform X4

    5. XM_011533651.4 → XP_011531953.1  eukaryotic translation initiation factor 4E type 3 isoform X3

      Conserved Domains (1) summary
      pfam01652
      Location:51 → 146
      IF4E; Eukaryotic initiation factor 4E

    6. XM_047448064.1 → XP_047304020.1  eukaryotic translation initiation factor 4E type 3 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      71698509..71794043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346403.1 → XP_054202378.1  eukaryotic translation initiation factor 4E type 3 isoform X2

    2. XM_054346402.1 → XP_054202377.1  eukaryotic translation initiation factor 4E type 3 isoform X1

    3. XM_054346405.1 → XP_054202380.1  eukaryotic translation initiation factor 4E type 3 isoform X4

    4. XM_054346404.1 → XP_054202379.1  eukaryotic translation initiation factor 4E type 3 isoform X3

    5. XM_054346406.1 → XP_054202381.1  eukaryotic translation initiation factor 4E type 3 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N5X7.4 GenPept UniProtKB/Swiss-Prot:Q8N5X7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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