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    OR51B5 olfactory receptor family 51 subfamily B member 5 [ Homo sapiens (human) ]

    Gene ID: 282763, updated on 2-Nov-2024

    Summary

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    Official Symbol
    OR51B5provided by HGNC
    Official Full Name
    olfactory receptor family 51 subfamily B member 5provided by HGNC
    Primary source
    HGNC:HGNC:19599
    See related
    Ensembl:ENSG00000167355 AllianceGenome:HGNC:19599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR11-37; HOR5'Beta5
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See OR51B5 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5340318..5505652, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5399679..5564994, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5361548..5526882, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 51 subfamily B member 2 Neighboring gene olfactory receptor family 51 subfamily B member 8 pseudogene Neighboring gene amphiphysin pseudogene Neighboring gene olfactory receptor family 51 subfamily B member 6 Neighboring gene TMEM258 pseudogene 1 Neighboring gene beta-globin hypersensitive site -107 Neighboring gene beta-globin hypersensitive site -111 Neighboring gene olfactory receptor family 51 subfamily M member 1 Neighboring gene olfactory receptor family 51 subfamily J member 1 Neighboring gene olfactory receptor family 51 subfamily Q member 1 Neighboring gene olfactory receptor family 51 subfamily K member 1 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr11:5473662-5474235 Neighboring gene olfactory receptor family 51 subfamily I member 1 Neighboring gene olfactory receptor family 51 subfamily I member 2 Neighboring gene olfactory receptor family 51 subfamily A member 10 pseudogene Neighboring gene olfactory receptor family 52 subfamily D member 1 Neighboring gene ubiquilin 3 Neighboring gene ubiquilin like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Dermal Olfactory Receptor OR51B5 Is Essential for Survival and Collagen Synthesis in Human Dermal Fibroblast (Hs68 Cells). Son B, et al. Int J Mol Sci, 2021 Aug 27. PMID 34502185, Free PMC Article
    2. Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer. Sera T, et al. Anticancer Res, 2022 Nov. PMID 36288877
    3. Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. Tsai T, et al. Exp Dermatol, 2017 Jan. PMID 27315375
    4. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. Solovieff N, et al. Blood, 2010 Mar 4. PMID 20018918, Free PMC Article
    5. Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Bulger M, et al. Proc Natl Acad Sci U S A, 1999 Apr 27. PMID 10220430, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer.
      Title: Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development of Scirrhous-type Gastric Cancer.
    2. Dermal Olfactory Receptor OR51B5 Is Essential for Survival and Collagen Synthesis in Human Dermal Fibroblast (Hs68 Cells).
      Title: Dermal Olfactory Receptor OR51B5 Is Essential for Survival and Collagen Synthesis in Human Dermal Fibroblast (Hs68 Cells).
    3. OR51B5 and ISO play important roles in HaCaT and keratinocyte migration, thereby influencing wound healing.
      Title: Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.
    4. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of smell NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 51B5
    Names
    odorant receptor HOR5'beta5
    olfactory receptor OR11-37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005567.3 → NP_001005567.2  olfactory receptor 51B5

      See identical proteins and their annotated locations for NP_001005567.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the olfactory receptor 51B5.
      Source sequence(s)
      AC087380, AC104389
      Consensus CDS
      CCDS31378.1
      UniProtKB/Swiss-Prot
      B2RN59, Q9H339
      UniProtKB/TrEMBL
      A0A126GWB8
      Conserved Domains (1) summary
      cd15222
      Location:23 → 297
      7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001395252.1 → NP_001382181.1  olfactory receptor 51B5

      Status: VALIDATED

      Source sequence(s)
      AC104389
      Consensus CDS
      CCDS31378.1
      UniProtKB/Swiss-Prot
      B2RN59, Q9H339
      UniProtKB/TrEMBL
      A0A126GWB8
      Related
      ENSP00000300773.2, ENST00000300773.3
      Conserved Domains (1) summary
      cd15222
      Location:23 → 297
      7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. NR_038321.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 3' exon and is a non-coding transcript compared to variant 1.
      Source sequence(s)
      AC104389, BG776801
      Related
      ENST00000415970.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      5340318..5505652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      5399679..5564994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H339.2 GenPept UniProtKB/Swiss-Prot:Q9H339

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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