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    ZNF714 zinc finger protein 714 [ Homo sapiens (human) ]

    Gene ID: 148206, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ZNF714provided by HGNC
    Official Full Name
    zinc finger protein 714provided by HGNC
    Primary source
    HGNC:HGNC:27124
    See related
    Ensembl:ENSG00000160352 AllianceGenome:HGNC:27124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thyroid (RPKM 4.5), ovary (RPKM 3.5) and 21 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF714 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (21082203..21125094)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (21220849..21263764)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21265009..21307897)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:21203153-21203746 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:21203747-21204338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:21206984-21207484 Neighboring gene zinc finger protein 430 Neighboring gene vomeronasal 1 receptor 80 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14381 Neighboring gene RNA, 5S ribosomal pseudogene 469 Neighboring gene CRISPRi-validated cis-regulatory element chr19.3196 Neighboring gene MPRA-validated peak3406 silencer Neighboring gene vomeronasal 1 receptor 81 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14382 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:21326130-21327329 Neighboring gene zinc finger protein 431 Neighboring gene ribosomal protein L7a pseudogene 10 Neighboring gene vomeronasal 1 receptor 82 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF714 Supports Pro-Oncogenic Features in Lung Cancer Cells.
      Title: ZNF714 Supports Pro-Oncogenic Features in Lung Cancer Cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33668, FLJ43674, DKFZp547O168

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 714

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182515.4 → NP_872321.2  zinc finger protein 714

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein.
      Source sequence(s)
      AC010620, BC022527, BC050468, DB028091
      Consensus CDS
      CCDS54239.1
      UniProtKB/TrEMBL
      A0A087WU35
      Related
      ENSP00000478345.1, ENST00000456283.7
      Conserved Domains (4) summary
      smart00349
      Location:2 → 36
      KRAB; krueppel associated box
      COG5048
      Location:171 → 504
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:399 → 419
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:439 → 464
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_117086.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site, contains an additional internal exon, and splices out part of the 3' region resulting in an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC010620, AC012627, BC022527, KF573658
      Related
      ENST00000613286.4

    2. NR_117087.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) splices out part of the 3' region resulting in an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC010620, BC050468, DA026469

    3. NR_117088.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for non-stop mRNA decay (NSD).
      Source sequence(s)
      BC022527, CN341038, DA026469

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      21082203..21125094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      21220849..21263764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96N38.3 GenPept UniProtKB/Swiss-Prot:Q96N38

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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