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    LRRC14B leucine rich repeat containing 14B [ Homo sapiens (human) ]

    Gene ID: 389257, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LRRC14Bprovided by HGNC
    Official Full Name
    leucine rich repeat containing 14Bprovided by HGNC
    Primary source
    HGNC:HGNC:37268
    See related
    Ensembl:ENSG00000185028 AllianceGenome:HGNC:37268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a leucine-rich repeat containing protein that is a member of the PRAME family. [provided by RefSeq, Apr 2017]
    Expression
    Biased expression in heart (RPKM 5.9) and prostate (RPKM 0.8) See more
    Orthologs
    mouse all
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    Genomic context

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    See LRRC14B in Genome Data Viewer
    Location:
    5p15.33
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (191495..196334)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (182851..187790)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (191610..196449)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:72025-72555 Neighboring gene Spi-C transcription factor pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:77366-78265 Neighboring gene Sharpr-MPRA regulatory region 259 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:90483-91322 Neighboring gene NANOG hESC enhancer GRCh37_chr5:99879-100414 Neighboring gene pleckstrin homology and RhoGEF domain containing G4B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:137535-138040 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159786-160286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:160287-160787 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:169157-170356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170845-171358 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:171359-171872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:181876-182376 Neighboring gene Sharpr-MPRA regulatory region 15179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22268 Neighboring gene Sharpr-MPRA regulatory region 11960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22270 Neighboring gene uncharacterized LOC124900929 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:207882-208207 Neighboring gene coiled-coil domain containing 127 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:218445-219253 Neighboring gene succinate dehydrogenase complex flavoprotein subunit A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. Seo G, et al. Cell Rep, 2020 Jul 7. PMID 32640226, Free PMC Article
    2. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 14B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053103.1 RefSeqGene

      Range
      4985..9824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001080478.3 → NP_001073947.1  leucine-rich repeat-containing protein 14B

      See identical proteins and their annotated locations for NP_001073947.1

      Status: REVIEWED

      Source sequence(s)
      AC021087
      Consensus CDS
      CCDS47184.1
      UniProtKB/Swiss-Prot
      A6NHZ5
      Related
      ENSP00000327675.3, ENST00000328278.4
      Conserved Domains (3) summary
      cd00116
      Location:264 → 419
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:306 → 332
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:281 → 304
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      191495..196334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      182851..187790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NHZ5.3 GenPept UniProtKB/Swiss-Prot:A6NHZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials