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    Dnah14 dynein, axonemal, heavy chain 14 [ Mus musculus (house mouse) ]

    Gene ID: 240960, updated on 9-Aug-2024

    Summary

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    Official Symbol
    Dnah14provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 14provided by MGI
    Primary source
    MGI:MGI:2444525
    See related
    Ensembl:ENSMUSG00000047369 AllianceGenome:MGI:2444525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm980; Dnahc14; Gm18554; A230079K17Rik
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of dynein complex. Orthologous to human DNAH14 (dynein axonemal heavy chain 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 3.8) and cortex adult (RPKM 0.1) See more
    Orthologs
    human all
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    Genomic context

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    See Dnah14 in Genome Data Viewer
    Location:
    1 H4- H5; 1 84.83 cM
    Exon count:
    87
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (181404158..181642306)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (181576593..181814932)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 121, retrogene 1 Neighboring gene STARR-seq mESC enhancer starr_03239 Neighboring gene STARR-positive B cell enhancer mm9_chr1:183475630-183475931 Neighboring gene predicted gene, 32767 Neighboring gene STARR-seq mESC enhancer starr_03241 Neighboring gene predicted gene, 33612 Neighboring gene STARR-seq mESC enhancer starr_03242 Neighboring gene predicted gene, 23690 Neighboring gene STARR-positive B cell enhancer ABC_E5877 Neighboring gene STARR-positive B cell enhancer ABC_E3345 Neighboring gene lamin B receptor Neighboring gene predicted gene 5533

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal heavy chain 14
    Names
    dynein, axonemal, heavy chain 14 pseudogene
    NP_001363968.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377039.1 → NP_001363968.1  dynein axonemal heavy chain 14

      Status: VALIDATED

      Source sequence(s)
      AC113509, AC120366, AC165229
      UniProtKB/TrEMBL
      A0A571BGC3
      Related
      ENSMUSP00000158787.3, ENSMUST00000238412.3
      Conserved Domains (6) summary
      COG5245
      Location:1202 → 4193
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08393
      Location:973 → 1378
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1511 → 1845
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12781
      Location:3348 → 3563
      AAA_9; ATP-binding dynein motor region D5
      pfam18199
      Location:4202 → 4595
      Dynein_C; Dynein heavy chain C-terminal domain
      pfam13767
      Location:328 → 391
      DUF4168; Domain of unknown function (DUF4168)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      181404158..181642306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_018673.1: Suppressed sequence

      Description
      NG_018673.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.

    2. NM_172846.2: Suppressed sequence

      Description
      NM_172846.2: This RefSeq was temporarily suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version

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