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    Tnfrsf25 tumor necrosis factor receptor superfamily, member 25 [ Mus musculus (house mouse) ]

    Gene ID: 85030, updated on 12-May-2024

    Summary

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    Official Symbol
    Tnfrsf25provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 25provided by MGI
    Primary source
    MGI:MGI:1934667
    See related
    Ensembl:ENSMUSG00000024793 AllianceGenome:MGI:1934667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DR3; TR3; Wsl; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; Tnfrsf12
    Summary
    Predicted to be active in plasma membrane. Orthologous to human TNFRSF25 (TNF receptor superfamily member 25). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 5.7), spleen adult (RPKM 5.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnfrsf25 in Genome Data Viewer
    Location:
    4 E2; 4 82.89 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152199985..152204568)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152115528..152120119)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene nucleolar protein 9 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 5 Neighboring gene STARR-seq mESC enhancer starr_12195 Neighboring gene espin Neighboring gene espin-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10294 Neighboring gene STARR-positive B cell enhancer ABC_E4735 Neighboring gene predicted gene 13077

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells. Luo S, et al. Cell Mol Life Sci, 2023 Feb 27. PMID 36847849, Free PMC Article
    2. Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn's Disease-Like Ileitis. Li Z, et al. Front Immunol, 2018. PMID 29545797, Free PMC Article
    3. Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation. Singh RK, et al. Cell Immunol, 2017 Oct. PMID 28942944, Free PMC Article
    4. Death receptor 3 mediates TNFSF15- and TNFα-induced endothelial cell apoptosis. Xu LX, et al. Int J Biochem Cell Biol, 2014 Oct. PMID 25161149
    5. Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival. Wolf D, et al. Transplantation, 2012 Sep 27. PMID 22902792

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption.
      Title: Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption.
    2. The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells.
      Title: The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells.
    3. Host versus cell-dependent effects of beta-arrestin 1 expression in prostate tumorigenesis.
      Title: Host versus cell-dependent effects of β-arrestin 1 expression in prostate tumorigenesis.
    4. Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo.
      Title: Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo.
    5. The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens.
      Title: The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens.
    6. DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus.
      Title: DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus.
    7. Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease.
      Title: Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease.
    8. In contrast to pre-menopausal females, post-menopausal serum levels of TL1A are not significantly elevated and that DR3 expression is not induced on CD14+ monocytes. Murine ovariectomy (OVX) model of estrogen-deficiency revealed that early post-OVX expression of DR3 on CD4+ T cells is significantly elevated suggesting that DR3 and TL1A could play a potentially indirect role in early post-menopausal bone loss.
      Title: Oestrogen-deficiency induces bone loss by modulating CD14(+) monocyte and CD4(+) T cell DR3 expression and serum TL1A levels.
    9. this study shows that DR3 signaling modulates a multicellular network, encompassing Tregs, T effectors, and innate lymphoid cells, governing disease development and progression in SAMP mice with Crohn's disease-like ileitis
      Title: Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn's Disease-Like Ileitis.
    10. in vivo targeting of the TNF superfamily receptor TNFRSF25 using the TL1A-Ig fusion protein, along with IL-2, resulted in transient but massive Treg expansion in donor mice; transplantation of Treg-expanded donor cells facilitated transplant tolerance without GVHD, with complete sparing of graft-versus-malignancy.
      Title: Marked in Vivo Donor Regulatory T Cell Expansion via Interleukin-2 and TL1A-Ig Stimulation Ameliorates Graft-versus-Host Disease but Preserves Graft-versus-Leukemia in Recipients after Hematopoietic Stem Cell Transplantation.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 25
    Names
    tumor necrosis factor receptor superfamily, member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291010.2 → NP_001277939.1  tumor necrosis factor receptor superfamily member 25 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001277939.1

      Status: VALIDATED

      Source sequence(s)
      AL772240
      Consensus CDS
      CCDS71527.1
      UniProtKB/TrEMBL
      B1AWN9, Q99MM1
      Related
      ENSMUSP00000025706.4, ENSMUST00000025706.10
      Conserved Domains (2) summary
      cd13420
      Location:37 → 150
      TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
      cl14633
      Location:328 → 404
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. NM_033042.5 → NP_149031.2  tumor necrosis factor receptor superfamily member 25 isoform 2 precursor

      See identical proteins and their annotated locations for NP_149031.2

      Status: VALIDATED

      Source sequence(s)
      AL772240
      Consensus CDS
      CCDS38983.1
      UniProtKB/TrEMBL
      Q8VD70, Q99MM1
      Related
      ENSMUSP00000047823.8, ENSMUST00000035275.8
      Conserved Domains (2) summary
      cd13420
      Location:50 → 163
      TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
      cl14633
      Location:304 → 380
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      152199985..152204568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539318.2 → XP_006539381.1  tumor necrosis factor receptor superfamily member 25 isoform X1

      UniProtKB/TrEMBL
      Q99MM1
      Conserved Domains (2) summary
      cd13420
      Location:50 → 163
      TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
      cl14633
      Location:341 → 417
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. XM_030253942.1 → XP_030109802.1  tumor necrosis factor receptor superfamily member 25 isoform X4

      Conserved Domains (1) summary
      cl14633
      Location:157 → 233
      DD; Death Domain Superfamily of protein-protein interaction domains

    3. XM_011250362.1 → XP_011248664.1  tumor necrosis factor receptor superfamily member 25 isoform X3

      Conserved Domains (1) summary
      cl14633
      Location:177 → 253
      DD; Death Domain Superfamily of protein-protein interaction domains

    4. XM_006539319.2 → XP_006539382.1  tumor necrosis factor receptor superfamily member 25 isoform X2

      UniProtKB/TrEMBL
      Q99MM1
      Conserved Domains (2) summary
      cd13420
      Location:66 → 157
      TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
      cl14633
      Location:335 → 411
      DD; Death Domain Superfamily of protein-protein interaction domains

    RNA

    1. XR_004942012.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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