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    MEIOC meiosis specific with coiled-coil domain [ Homo sapiens (human) ]

    Gene ID: 284071, updated on 27-Nov-2024

    Summary

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    Official Symbol
    MEIOCprovided by HGNC
    Official Full Name
    meiosis specific with coiled-coil domainprovided by HGNC
    Primary source
    HGNC:HGNC:26670
    See related
    Ensembl:ENSG00000180336 MIM:616934; AllianceGenome:HGNC:26670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C17orf104
    Summary
    Predicted to be involved in several processes, including germ cell development; germline cell cycle switching, mitotic to meiotic cell cycle; and meiosis I. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 25.4) See more
    Orthologs
    mouse all
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    Genomic context

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    See MEIOC in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (44656468..44677087)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (45510420..45531046)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42733836..42753169)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:42634117-42634884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42635102-42636062 Neighboring gene MPRA-validated peak2866 silencer Neighboring gene frizzled class receptor 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:42664661-42665226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:42675147-42675724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:42684805-42685416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8598 Neighboring gene long intergenic non-protein coding RNA 1180 Neighboring gene single-pass membrane protein with coiled-coil domains 4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8599 Neighboring gene uncharacterized LOC105371792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:42766877-42767466 Neighboring gene uncharacterized LOC124904010 Neighboring gene coiled-coil domain containing 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts. Abby E, et al. Nat Commun, 2016 Jan 8. PMID 26742488, Free PMC Article
    2. TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease. Seo BA, et al. Neuron, 2021 Dec 1. PMID 34644545, Free PMC Article
    3. RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy. Radaszkiewicz T, et al. Elife, 2021 Oct 27. PMID 34702444, Free PMC Article
    4. Proximity labeling reveals dynamic changes in the SQSTM1 protein network. Rondón-Ortiz AN, et al. J Biol Chem, 2024 Sep. PMID 39098523, Free PMC Article
    5. Generation and analysis of 280,000 human expressed sequence tags. Hillier LD, et al. Genome Res, 1996 Sep. PMID 8889549

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Meioc is expressed in germ cells during meiotic prophase I. MEIOC prevents meiotic transcript degradation and interacts with an RNA helicase that binds numerous meiotic mRNAs.
      Title: Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35848, FLJ40428, MGC43301

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in chromosome organization involved in meiotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female meiosis I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germline cell cycle switching, mitotic to meiotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male meiosis I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase chromosome alignment IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptonemal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    meiosis-specific coiled-coil domain-containing protein MEIOC
    Names
    meiosis-specific with coiled-coil domain protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145080.3 → NP_001138552.2  meiosis-specific coiled-coil domain-containing protein MEIOC

      See identical proteins and their annotated locations for NP_001138552.2

      Status: VALIDATED

      Source sequence(s)
      AA205120, AC091152, BC041481, DB460166, DV080633
      Consensus CDS
      CCDS45703.2
      UniProtKB/Swiss-Prot
      A2RUB1, B4DXJ2, B5MD93, B9EGQ6, C4AM97, Q4G0Y1, Q8IVZ7, Q8NA45
      Related
      ENSP00000386452.1, ENST00000409122.7
      Conserved Domains (1) summary
      pfam15189
      Location:747 → 912
      DUF4582; Domain of unknown function (DUF4582)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      44656468..44677087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257236.4 → XP_005257293.1  meiosis-specific coiled-coil domain-containing protein MEIOC isoform X1

      Conserved Domains (1) summary
      pfam15189
      Location:747 → 912
      DUF4582; Domain of unknown function (DUF4582)

    2. XM_047435802.1 → XP_047291758.1  meiosis-specific coiled-coil domain-containing protein MEIOC isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      45510420..45531046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315781.1 → XP_054171756.1  meiosis-specific coiled-coil domain-containing protein MEIOC isoform X1

    2. XM_054315782.1 → XP_054171757.1  meiosis-specific coiled-coil domain-containing protein MEIOC isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033659.2: Suppressed sequence

      Description
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RUB1.3 GenPept UniProtKB/Swiss-Prot:A2RUB1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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