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    C11orf24 chromosome 11 open reading frame 24 [ Homo sapiens (human) ]

    Gene ID: 53838, updated on 2-Nov-2024

    Summary

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    Official Symbol
    C11orf24provided by HGNC
    Official Full Name
    chromosome 11 open reading frame 24provided by HGNC
    Primary source
    HGNC:HGNC:1174
    See related
    Ensembl:ENSG00000171067 MIM:610880; AllianceGenome:HGNC:1174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DM4E3
    Summary
    Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in small intestine (RPKM 25.6), duodenum (RPKM 22.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C11orf24 in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (68261338..68271973, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (68264928..68276330, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68028806..68039441, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67888828-67889593 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67889594-67890360 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:67907579-67907779 Neighboring gene CHKA divergent transcript Neighboring gene lysine methyltransferase 5B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67981441-67982143 Neighboring gene Sharpr-MPRA regulatory region 2086 Neighboring gene MPRA-validated peak1319 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:68034746-68035945 Neighboring gene uncharacterized LOC105369363 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68039550-68040404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5134 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68066209-68066956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68067706-68068453 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68080045-68080920 Neighboring gene uncharacterized LOC124900302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68080921-68081795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68082507-68083006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68084075-68084742 Neighboring gene LDL receptor related protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. C11ORF24 is a novel type I membrane protein that cycles between the Golgi apparatus and the plasma membrane in Rab6-positive vesicles. Fraisier V, et al. PLoS One, 2013. PMID 24312644, Free PMC Article
    2. The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13. Twells RC, et al. Genomics, 2001 Mar 15. PMID 11401438
    3. Large-scale cDNA transfection screening for genes related to cancer development and progression. Wan D, et al. Proc Natl Acad Sci U S A, 2004 Nov 2. PMID 15498874, Free PMC Article
    4. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article
    5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein C11orf24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300913.2 → NP_001287842.1  uncharacterized protein C11orf24 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001287842.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AP002813, BC011765, BI862360, BX384793, DB471655
      Consensus CDS
      CCDS73338.1
      UniProtKB/TrEMBL
      E9PRU5

    2. NM_022338.4 → NP_071733.1  uncharacterized protein C11orf24 isoform 1 precursor

      See identical proteins and their annotated locations for NP_071733.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF264781, BC011765, BG701401
      Consensus CDS
      CCDS8180.1
      UniProtKB/Swiss-Prot
      Q96F05, Q9H2K4
      Related
      ENSP00000307264.6, ENST00000304271.11
      Conserved Domains (1) summary
      PHA03247
      Location:133 → 391
      PHA03247; large tegument protein UL36; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      68261338..68271973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427129.1 → XP_047283085.1  uncharacterized protein C11orf24 isoform X3

      UniProtKB/TrEMBL
      E9PRU5
      Related
      ENSP00000434144.1, ENST00000533310.5

    2. XM_005274053.5 → XP_005274110.1  uncharacterized protein C11orf24 isoform X1

      See identical proteins and their annotated locations for XP_005274110.1

      UniProtKB/Swiss-Prot
      Q96F05, Q9H2K4
      Conserved Domains (1) summary
      PHA03247
      Location:133 → 391
      PHA03247; large tegument protein UL36; Provisional

    3. XM_011545103.4 → XP_011543405.1  uncharacterized protein C11orf24 isoform X2

      Conserved Domains (1) summary
      PHA03247
      Location:101 → 359
      PHA03247; large tegument protein UL36; Provisional

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      68264928..68276330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369136.1 → XP_054225111.1  uncharacterized protein C11orf24 isoform X1

      UniProtKB/Swiss-Prot
      Q96F05, Q9H2K4

    2. XM_054369138.1 → XP_054225113.1  uncharacterized protein C11orf24 isoform X3

      UniProtKB/TrEMBL
      E9PRU5

    3. XM_054369137.1 → XP_054225112.1  uncharacterized protein C11orf24 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96F05.2 GenPept UniProtKB/Swiss-Prot:Q96F05

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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