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    Ghdc GH3 domain containing [ Mus musculus (house mouse) ]

    Gene ID: 80860, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ghdcprovided by MGI
    Official Full Name
    GH3 domain containingprovided by MGI
    Primary source
    MGI:MGI:1931556
    See related
    Ensembl:ENSMUSG00000017747 AllianceGenome:MGI:1931556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D11Lgp1e
    Summary
    Predicted to enable acid-amino acid ligase activity. Located in endoplasmic reticulum. Orthologous to human GHDC (GH3 domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 11.2), kidney adult (RPKM 10.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ghdc in Genome Data Viewer
    Location:
    11 D; 11 63.6 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100656852..100661772, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100766026..100770973, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 4 Neighboring gene STARR-positive B cell enhancer ABC_E8452 Neighboring gene STARR-positive B cell enhancer ABC_E5278 Neighboring gene STARR-positive B cell enhancer ABC_E8453 Neighboring gene hypocretin Neighboring gene signal transducer and activator of transcription 5B Neighboring gene STARR-positive B cell enhancer ABC_E8454 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100681071-100681254 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100707044-100707332 Neighboring gene signal transducer and activator of transcription 5A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue. Cui Y, et al. Genomics, 2001 Dec. PMID 11735219
    2. Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse. Miyoshi K, et al. Genomics, 2001 Jan 15. PMID 11161808
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acid-amino acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GH3 domain-containing protein
    Names
    D11lgp1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418306.1 → NP_001405235.1  GH3 domain-containing protein isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL591466

    2. NM_031871.2 → NP_114077.1  GH3 domain-containing protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_114077.1

      Status: VALIDATED

      Source sequence(s)
      AL591466
      Consensus CDS
      CCDS25437.1
      UniProtKB/Swiss-Prot
      A2A5D7, Q99J23, Q99J92
      UniProtKB/TrEMBL
      Q3UNZ1, Q3UXS5
      Related
      ENSMUSP00000017891.8, ENSMUST00000017891.14
      Conserved Domains (2) summary
      cl21606
      Location:207 → 532
      PLN02247; indole-3-acetic acid-amido synthetase
      pfam03321
      Location:55 → 500
      GH3; GH3 auxin-responsive promoter

    RNA

    1. NR_184712.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591466

    2. NR_184713.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL591466

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100656852..100661772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99J23.2 GenPept UniProtKB/Swiss-Prot:Q99J23

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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