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    Sytl5 synaptotagmin-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 236643, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sytl5provided by MGI
    Official Full Name
    synaptotagmin-like 5provided by MGI
    Primary source
    MGI:MGI:2668451
    See related
    Ensembl:ENSMUSG00000054453 AllianceGenome:MGI:2668451
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    slp5
    Summary
    Predicted to enable neurexin family protein binding activity. Acts upstream of or within exocytosis. Predicted to be located in membrane. Predicted to be active in exocytic vesicle and plasma membrane. Orthologous to human SYTL5 (synaptotagmin like 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 1.4), liver E18 (RPKM 0.5) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sytl5 in Genome Data Viewer
    Location:
    X A1.1; X 4.62 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (9613851..9871268)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (9747622..9998864)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46712 Neighboring gene H2A histone family member L1O Neighboring gene STARR-seq mESC enhancer starr_46713 Neighboring gene dynein light chain Tctex-type 3 Neighboring gene STARR-seq mESC enhancer starr_46715 Neighboring gene H2A histone family member L3 Neighboring gene H2A.P histone Neighboring gene STARR-seq mESC enhancer starr_46716 Neighboring gene predicted gene 5754 Neighboring gene STARR-seq mESC enhancer starr_46717 Neighboring gene sushi-repeat-containing protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains. Kuroda TS, et al. Biochem Biophys Res Commun, 2002 May 10. PMID 12051743
    2. Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. Fukuda M. J Biol Chem, 2003 Apr 25. PMID 12590134
    3. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA. Scavuzzo MA, et al. Cell Rep, 2018 Dec 26. PMID 30590051
    4. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
    5. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-like protein 5

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290728.1 → NP_001277657.1  synaptotagmin-like protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001277657.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL672031, BX547929
      Consensus CDS
      CCDS72342.1
      UniProtKB/Swiss-Prot
      Q80T23
      Related
      ENSMUSP00000083339.4, ENSMUST00000086165.4
      Conserved Domains (4) summary
      cd04020
      Location:545 → 723
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:408 → 531
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    2. NM_177704.3 → NP_808372.1  synaptotagmin-like protein 5 isoform 1

      See identical proteins and their annotated locations for NP_808372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL672031, BX547929
      Consensus CDS
      CCDS40860.1
      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Related
      ENSMUSP00000064826.3, ENSMUST00000067529.9
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      9613851..9871268
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318467.3 → XP_017173956.1  synaptotagmin-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    2. XM_011247463.4 → XP_011245765.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011245765.1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    3. XM_011247469.4 → XP_011245771.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011245771.1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    4. XM_036161915.1 → XP_036017808.1  synaptotagmin-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    5. XM_006527604.5 → XP_006527667.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006527667.1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    6. XM_006527608.5 → XP_006527671.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006527671.1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    7. XM_011247470.4 → XP_011245772.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011245772.1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    8. XM_036161913.1 → XP_036017806.1  synaptotagmin-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    9. XM_011247473.2 → XP_011245775.1  synaptotagmin-like protein 5 isoform X2

      See identical proteins and their annotated locations for XP_011245775.1

      UniProtKB/Swiss-Prot
      Q80T23
      Conserved Domains (4) summary
      cd04020
      Location:545 → 723
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:408 → 531
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    10. XM_011247468.2 → XP_011245770.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011245770.1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    11. XM_011247465.2 → XP_011245767.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011245767.1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    12. XM_036161914.1 → XP_036017807.1  synaptotagmin-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    13. XM_011247464.2 → XP_011245766.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011245766.1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    14. XM_011247460.3 → XP_011245762.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011245762.1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    15. XM_011247471.3 → XP_011245773.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011245773.1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    16. XM_006527607.4 → XP_006527670.1  synaptotagmin-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006527670.1

      UniProtKB/Swiss-Prot
      A2AF59, Q80T23, Q812E5
      UniProtKB/TrEMBL
      A2AF58
      Conserved Domains (4) summary
      cd04020
      Location:567 → 745
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:430 → 553
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
      cd15766
      Location:62 → 108
      FYVE_Slp5; FYVE-related domain found in synaptotagmin-like protein 5 (Slp5) and similar proteins
      cl22851
      Location:11 → 123
      PHD_SF; PHD finger superfamily

    17. XM_030251313.2 → XP_030107173.1  synaptotagmin-like protein 5 isoform X3

      Conserved Domains (2) summary
      cd04020
      Location:283 → 461
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cd04029
      Location:146 → 269
      C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80T23.1 GenPept UniProtKB/Swiss-Prot:Q80T23

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