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    ODR4 odr-4 GPCR localization factor homolog [ Homo sapiens (human) ]

    Gene ID: 54953, updated on 9-Dec-2024

    Summary

    Official Symbol
    ODR4provided by HGNC
    Official Full Name
    odr-4 GPCR localization factor homologprovided by HGNC
    Primary source
    HGNC:HGNC:24299
    See related
    Ensembl:ENSG00000157181 MIM:609335; AllianceGenome:HGNC:24299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TTG1; odr-4; C1orf27
    Summary
    Predicted to be involved in protein localization. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 12.6), prostate (RPKM 9.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ODR4 in Genome Data Viewer
    Location:
    1q31.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (186375838..186435031)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (185730569..185776136)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (186344970..186390507)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904471 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:186214031-186214197 Neighboring gene RNA, U6 small nuclear 1240, pseudogene Neighboring gene proteoglycan 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:186312648-186313847 Neighboring gene MPRA-validated peak515 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:186323778-186324977 Neighboring gene translocated promoter region, nuclear basket protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2248 Neighboring gene PDC antisense RNA 1 Neighboring gene phosducin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:186481023-186481524 Neighboring gene parkin coregulated like pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20505

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein odr-4 homolog
    Names
    LAG1-interacting protein
    odorant response abnormal 4
    transactivated by recombinant transforming growth factor beta 1
    transactivated by transforming growth factor beta protein 1
    NP_001157717.1
    NP_001157718.1
    NP_060317.3
    XP_011507962.1
    XP_016857032.1
    XP_047279394.1
    XP_047279395.1
    XP_047279396.1
    XP_054193232.1
    XP_054193233.1
    XP_054193234.1
    XP_054193235.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164245.2NP_001157717.1  protein odr-4 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AL596220, AY854248, BC003397, DB116803, DQ529299
      Consensus CDS
      CCDS53449.1
      UniProtKB/Swiss-Prot
      Q5SWX8
      Related
      ENSP00000356440.3, ENST00000367470.8
      Conserved Domains (1) summary
      pfam14778
      Location:28362
      ODR4-like; Olfactory receptor 4-like
    2. NM_001164246.2NP_001157718.1  protein odr-4 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK298107, AL596220, AY854248, BC003397, DB116803
      Consensus CDS
      CCDS53450.1
      UniProtKB/Swiss-Prot
      Q5SWX8
      Related
      ENSP00000395084.3, ENST00000419367.8
      Conserved Domains (1) summary
      pfam14778
      Location:28353
      ODR4-like; Olfactory receptor 4-like
    3. NM_017847.6NP_060317.3  protein odr-4 homolog isoform 1

      See identical proteins and their annotated locations for NP_060317.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL596220, AY854248, BC003397, DB116803
      Consensus CDS
      CCDS53448.1
      UniProtKB/Swiss-Prot
      B4DNY0, E9PFR7, Q19CC6, Q5SWX8, Q8WYB6, Q9BTS2, Q9H6A6, Q9NX06
      Related
      ENSP00000287859.6, ENST00000287859.11
      Conserved Domains (1) summary
      pfam14778
      Location:28385
      ODR4-like; Olfactory receptor 4-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      186375838..186435031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423438.1XP_047279394.1  protein odr-4 homolog isoform X1

      UniProtKB/Swiss-Prot
      B4DNY0, E9PFR7, Q19CC6, Q5SWX8, Q8WYB6, Q9BTS2, Q9H6A6, Q9NX06
    2. XM_011509660.3XP_011507962.1  protein odr-4 homolog isoform X1

      See identical proteins and their annotated locations for XP_011507962.1

      UniProtKB/Swiss-Prot
      B4DNY0, E9PFR7, Q19CC6, Q5SWX8, Q8WYB6, Q9BTS2, Q9H6A6, Q9NX06
      Conserved Domains (1) summary
      pfam14778
      Location:28385
      ODR4-like; Olfactory receptor 4-like
    3. XM_047423439.1XP_047279395.1  protein odr-4 homolog isoform X2

    4. XM_047423440.1XP_047279396.1  protein odr-4 homolog isoform X3

    5. XM_017001543.3XP_016857032.1  protein odr-4 homolog isoform X4

    RNA

    1. XR_007061319.1 RNA Sequence

    2. XR_007061320.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      185730569..185776136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337257.1XP_054193232.1  protein odr-4 homolog isoform X1

    2. XM_054337258.1XP_054193233.1  protein odr-4 homolog isoform X2

    3. XM_054337259.1XP_054193234.1  protein odr-4 homolog isoform X3

    4. XM_054337260.1XP_054193235.1  protein odr-4 homolog isoform X4

    RNA

    1. XR_008486081.1 RNA Sequence