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    Herpud2 HERPUD family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 80517, updated on 11-Nov-2024

    Summary

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    Official Symbol
    Herpud2provided by MGI
    Official Full Name
    HERPUD family member 2provided by MGI
    Primary source
    MGI:MGI:1915393
    See related
    Ensembl:ENSMUSG00000008429 AllianceGenome:MGI:1915393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5031400M07Rik
    Summary
    Involved in spermatogenesis. Predicted to be located in membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human HERPUD2 (HERPUD family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 53.4), adrenal adult (RPKM 48.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Herpud2 in Genome Data Viewer
    Location:
    9 A4; 9 10.25 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (25012412..25063109, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (25108126..25151813, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130101E03 gene Neighboring gene transmembrane protein 126B pseudogene Neighboring gene STARR-seq mESC enhancer starr_23595 Neighboring gene STARR-seq mESC enhancer starr_23596 Neighboring gene predicted gene 29642 Neighboring gene STARR-seq mESC enhancer starr_23597 Neighboring gene RIKEN cDNA 9130004C02 gene Neighboring gene high mobility group box 2 pseudogene Neighboring gene septin 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species. Tonelli Gombalová Z, et al. J Comp Neurol, 2020 Oct 15. PMID 32212159
    2. Identification of differentially expressed genes in mouse spermatogenesis. Pang AL, et al. J Androl, 2003 Nov-Dec. PMID 14581517
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Spontaneous (1)  1 citation
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020586.2 → NP_065611.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein

      See identical proteins and their annotated locations for NP_065611.1

      Status: VALIDATED

      Source sequence(s)
      AC113082, CT025561
      Consensus CDS
      CCDS22934.1
      UniProtKB/Swiss-Prot
      Q8K2W2, Q9CSZ4, Q9D2D0, Q9JJC9
      Related
      ENSMUSP00000008573.8, ENSMUST00000008573.9
      Conserved Domains (2) summary
      cd01790
      Location:9 → 87
      Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
      smart00213
      Location:10 → 87
      UBQ; Ubiquitin homologues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      25012412..25063109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510706.4 → XP_006510769.1  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein isoform X1

      Conserved Domains (1) summary
      cd17119
      Location:9 → 85
      Ubl_HERP2; ubiquitin-like (Ubl) domain found in homocysteine-inducible endoplasmic reticulum stress protein HERP2 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJC9.1 GenPept UniProtKB/Swiss-Prot:Q9JJC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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