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    CDK11B cyclin dependent kinase 11B [ Homo sapiens (human) ]

    Gene ID: 984, updated on 3-Dec-2024

    Summary

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    Official Symbol
    CDK11Bprovided by HGNC
    Official Full Name
    cyclin dependent kinase 11Bprovided by HGNC
    Primary source
    HGNC:HGNC:1729
    See related
    Ensembl:ENSG00000248333 MIM:176873; AllianceGenome:HGNC:1729
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p58; PK58; CDK11; CLK-1; CDC2L1; PITSLREA; p58CLK-1; CDK11-p46; CDK11-p58; p58CDC2L1; CDK11-p110
    Summary
    This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
    Expression
    Ubiquitous expression in testis (RPKM 20.1), bone marrow (RPKM 18.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDK11B in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1635225..1659004, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1069728..1093685, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1570603..1590465, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MIB E3 ubiquitin protein ligase 2 Neighboring gene uncharacterized LOC124903821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1565596-1566158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1568259-1569070 Neighboring gene matrix metallopeptidase 23B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1590308-1591030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30 Neighboring gene solute carrier family 35 member E2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1601211-1601711 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 31 Neighboring gene Sharpr-MPRA regulatory region 10763 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:1618619-1618776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1619919-1620419 Neighboring gene Sharpr-MPRA regulatory region 15043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 88 Neighboring gene matrix metallopeptidase 23A (pseudogene)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DNA methylation of the CDC2L1 gene promoter region decreases the expression of the CDK11p58 protein and reduces apoptosis in keloid fibroblasts. Zhang G, et al. Arch Dermatol Res, 2018 Mar. PMID 29204684
    2. Targeting CDK11 in osteosarcoma cells using the CRISPR-Cas9 system. Feng Y, et al. J Orthop Res, 2015 Feb. PMID 25348612, Free PMC Article
    3. Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells. Jia B, et al. Cancer Lett, 2014 Jan 1. PMID 24007862, Free PMC Article
    4. Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation. Duan Z, et al. Clin Cancer Res, 2012 Sep 1. PMID 22791884
    5. Analyses of CDC2L1 gene mutations in keloid tissue. Zhang G, et al. Clin Exp Dermatol, 2012 Apr. PMID 22188294

    See all (139) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDK11 facilitates centromeric transcription to maintain centromeric cohesion during mitosis.
      Title: CDK11 facilitates centromeric transcription to maintain centromeric cohesion during mitosis.
    2. CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's Disease Encephalic Samples.
      Title: CDK10, CDK11, FOXO1, and FOXO3 Gene Expression in Alzheimer's Disease Encephalic Samples.
    3. Therapeutic potential of CDK11 in cancer.
      Title: Therapeutic potential of CDK11 in cancer.
    4. CDK11 negatively regulates Wnt/beta-catenin signaling in the endosomal compartment by affecting microtubule stability.
      Title: CDK11 negatively regulates Wnt/β-catenin signaling in the endosomal compartment by affecting microtubule stability.
    5. A cyclin-dependent kinase, CDK11/p58, represses cap-dependent translation during mitosis.
      Title: A cyclin-dependent kinase, CDK11/p58, represses cap-dependent translation during mitosis.
    6. CDK11 is required for transcription of replication-dependent histone genes.
      Title: CDK11 is required for transcription of replication-dependent histone genes.
    7. Transcriptional activation of CBFbeta by CDK11(p110) is necessary to promote osteosarcoma cell proliferation
      Title: Transcriptional activation of CBFβ by CDK11(p110) is necessary to promote osteosarcoma cell proliferation.
    8. These results provided evidence that CDK11(p110) play a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells, which suggests that CDK11(p110) may be a promising therapeutic target in esophageal squamous cell carcinoma.
      Title: CDK11(p110) plays a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells and is a potential drug target.
    9. These findings suggest that CDK11 is involved in the regulation of AR pathway and AR can be a potential novel prognostic marker and therapeutic target for osteosarcoma treatment.
      Title: Androgen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11.
    10. DNA methylation exists in the CDC2L1 gene promoter region in keloid tissue fibroblasts. DNA methylation of the CDC2L1 gene promoter region dramatically inhibits the expression of CDK11p58 protein in keloid tissues.
      Title: DNA methylation of the CDC2L1 gene promoter region decreases the expression of the CDK11p58 protein and reduces apoptosis in keloid fibroblasts.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat CDK11 depletion reduces protein expression of CDK9 and HEXIM1 and Tat transactivation of HIV-1 provirus PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ59152

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell growth IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of centrosome cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-dependent kinase 11B
    Names
    CDC-related protein kinase p58
    PITSLRE serine/threonine-protein kinase CDC2L1
    cell division cycle 2-like 1 (PITSLRE proteins)
    cell division protein kinase 11B
    galactosyltransferase-associated protein kinase p58/GTA
    p58 CLK-1
    NP_001278274.1
    NP_001778.2
    NP_277021.2
    NP_277022.1
    NP_277024.2
    NP_277025.1
    XP_006711128.1
    XP_011540792.1
    XP_011540793.1
    XP_011540794.1
    XP_011540795.1
    XP_011540796.1
    XP_016858414.1
    XP_016858415.1
    XP_016858417.1
    XP_024306958.1
    XP_047291284.1
    XP_047291286.1
    XP_047291311.1
    XP_047291316.1
    XP_047291317.1
    XP_047291318.1
    XP_047291319.1
    XP_047291323.1
    XP_047291324.1
    XP_047291325.1
    XP_047291327.1
    XP_054195777.1
    XP_054195778.1
    XP_054195779.1
    XP_054195780.1
    XP_054195781.1
    XP_054195782.1
    XP_054195783.1
    XP_054195784.1
    XP_054195785.1
    XP_054195786.1
    XP_054195787.1
    XP_054195788.1
    XP_054195789.1
    XP_054195790.1
    XP_054195791.1
    XP_054195792.1
    XP_054195793.1
    XP_054195794.1
    XP_054195795.1
    XP_054195796.1
    XP_054195797.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291345.2 → NP_001278274.1  cyclin-dependent kinase 11B isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses two alternate splice sites in the central coding region, compared to variant 1. The encoded isoform (10) is shorter, compared to isoform 1.
      Source sequence(s)
      AA778148, AK000081, BC140714, DB516340, DC295949, DC362247, FO704657
      UniProtKB/TrEMBL
      B4E3D9
      Conserved Domains (2) summary
      cd07843
      Location:409 → 700
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:412 → 702
      PLN00009; cyclin-dependent kinase A; Provisional

    2. NM_001787.3 → NP_001778.2  cyclin-dependent kinase 11B isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA778148, AK000081, BC140714, DB516340, DC362247, FO704657
      Consensus CDS
      CCDS72683.1
      UniProtKB/Swiss-Prot
      B7ZVY7, J3KTL7, J3QR29, J3QR44, O95265, P21127, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59
      UniProtKB/TrEMBL
      B4E3D9
      Related
      ENSP00000464036.2, ENST00000407249.7
      Conserved Domains (1) summary
      cd07843
      Location:432 → 723
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    3. NM_033486.3 → NP_277021.2  cyclin-dependent kinase 11B isoform 2

      See identical proteins and their annotated locations for NP_277021.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AA778148, AK000081, BC140714, DB516340, DC362247, FO704657
      Consensus CDS
      CCDS72684.1
      UniProtKB/TrEMBL
      B4E3D9
      Related
      ENSP00000463048.2, ENST00000341832.11
      Conserved Domains (2) summary
      cd07843
      Location:419 → 710
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:422 → 712
      PLN00009; cyclin-dependent kinase A; Provisional

    4. NM_033487.3 → NP_277022.1  cyclin-dependent kinase 11B isoform 3

      See identical proteins and their annotated locations for NP_277022.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA778148, AK000081, BC140714, DB516340, DC362247, FO704657
      UniProtKB/TrEMBL
      A4VCI5
      Conserved Domains (2) summary
      cd07843
      Location:163 → 454
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:166 → 456
      PLN00009; cyclin-dependent kinase A; Provisional

    5. NM_033489.3 → NP_277024.2  cyclin-dependent kinase 11B isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR and 5' coding region, and uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AA778148, AK000081, AK295607, BC140714, DB516340, DC362247, FO704657
      Consensus CDS
      CCDS72682.1
      UniProtKB/TrEMBL
      Q5QPR4
      Related
      ENSP00000464016.2, ENST00000340677.9
      Conserved Domains (2) summary
      cd07843
      Location:385 → 676
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:388 → 678
      PLN00009; cyclin-dependent kinase A; Provisional

    6. NM_033490.3 → NP_277025.1  cyclin-dependent kinase 11B isoform 6

      See identical proteins and their annotated locations for NP_277025.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in its 5' UTR, uses a downstream start codon, and uses an alternate splice site in its 5' coding region, compared to variant 1. The encoded isoform (6) is shorter, compared to isoform 1.
      Source sequence(s)
      AA778148, AK000081, BC140714, DB516340, DC362247, FO704657
      UniProtKB/TrEMBL
      A4VCI5
      Conserved Domains (2) summary
      cd07843
      Location:202 → 493
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:205 → 495
      PLN00009; cyclin-dependent kinase A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      1635225..1659004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711065.5 → XP_006711128.1  cyclin-dependent kinase 11B isoform X5

      UniProtKB/TrEMBL
      B4E3D9
      Conserved Domains (2) summary
      cd07843
      Location:422 → 713
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:425 → 715
      PLN00009; cyclin-dependent kinase A; Provisional

    2. XM_017002926.3 → XP_016858415.1  cyclin-dependent kinase 11B isoform X6

      UniProtKB/TrEMBL
      B4E3D9
      Related
      ENSP00000485705.1, ENST00000626918.2

    3. XM_011542493.4 → XP_011540795.1  cyclin-dependent kinase 11B isoform X3

      UniProtKB/TrEMBL
      B4E3D9
      Conserved Domains (2) summary
      cd07843
      Location:431 → 722
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:434 → 724
      PLN00009; cyclin-dependent kinase A; Provisional

    4. XM_017002925.3 → XP_016858414.1  cyclin-dependent kinase 11B isoform X4

      UniProtKB/TrEMBL
      B4E3D9

    5. XM_011542490.4 → XP_011540792.1  cyclin-dependent kinase 11B isoform X1

      See identical proteins and their annotated locations for XP_011540792.1

      UniProtKB/TrEMBL
      B4E3D9
      Conserved Domains (2) summary
      cd07843
      Location:441 → 732
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:444 → 734
      PLN00009; cyclin-dependent kinase A; Provisional

    6. XM_047435361.1 → XP_047291317.1  cyclin-dependent kinase 11B isoform X11

      UniProtKB/TrEMBL
      B4E3D9

    7. XM_047435330.1 → XP_047291286.1  cyclin-dependent kinase 11B isoform X2

      UniProtKB/Swiss-Prot
      B7ZVY7, J3KTL7, J3QR29, J3QR44, O95265, P21127, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59
      UniProtKB/TrEMBL
      B4E3D9

    8. XM_011542492.3 → XP_011540794.1  cyclin-dependent kinase 11B isoform X1

      See identical proteins and their annotated locations for XP_011540794.1

      UniProtKB/TrEMBL
      B4E3D9
      Conserved Domains (2) summary
      cd07843
      Location:441 → 732
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:444 → 734
      PLN00009; cyclin-dependent kinase A; Provisional

    9. XM_047435328.1 → XP_047291284.1  cyclin-dependent kinase 11B isoform X2

      UniProtKB/Swiss-Prot
      B7ZVY7, J3KTL7, J3QR29, J3QR44, O95265, P21127, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59
      UniProtKB/TrEMBL
      B4E3D9

    10. XM_011542491.3 → XP_011540793.1  cyclin-dependent kinase 11B isoform X1

      See identical proteins and their annotated locations for XP_011540793.1

      UniProtKB/TrEMBL
      B4E3D9
      Conserved Domains (2) summary
      cd07843
      Location:441 → 732
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:444 → 734
      PLN00009; cyclin-dependent kinase A; Provisional

    11. XM_047435362.1 → XP_047291318.1  cyclin-dependent kinase 11B isoform X12

      UniProtKB/TrEMBL
      B4E3D9

    12. XM_047435360.1 → XP_047291316.1  cyclin-dependent kinase 11B isoform X10

      UniProtKB/TrEMBL
      Q5QPR4

    13. XM_047435355.1 → XP_047291311.1  cyclin-dependent kinase 11B isoform X9

      UniProtKB/TrEMBL
      Q5QPR4

    14. XM_017002928.3 → XP_016858417.1  cyclin-dependent kinase 11B isoform X8

      UniProtKB/TrEMBL
      Q5QPR4

    15. XM_011542494.4 → XP_011540796.1  cyclin-dependent kinase 11B isoform X7

      UniProtKB/TrEMBL
      Q5QPR4
      Conserved Domains (1) summary
      cd07843
      Location:407 → 698
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    16. XM_047435367.1 → XP_047291323.1  cyclin-dependent kinase 11B isoform X14

      UniProtKB/TrEMBL
      A4VCI5

    17. XM_024451190.2 → XP_024306958.1  cyclin-dependent kinase 11B isoform X18

      UniProtKB/TrEMBL
      Q96CA8
      Conserved Domains (1) summary
      cd07843
      Location:34 → 325
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1

    18. XM_047435363.1 → XP_047291319.1  cyclin-dependent kinase 11B isoform X13

    19. XM_047435371.1 → XP_047291327.1  cyclin-dependent kinase 11B isoform X17

      UniProtKB/TrEMBL
      J3KS35

    20. XM_047435369.1 → XP_047291325.1  cyclin-dependent kinase 11B isoform X16

    21. XM_047435368.1 → XP_047291324.1  cyclin-dependent kinase 11B isoform X15

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      1069728..1093685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339805.1 → XP_054195780.1  cyclin-dependent kinase 11B isoform X2

      UniProtKB/Swiss-Prot
      B7ZVY7, J3KTL7, J3QR29, J3QR44, O95265, P21127, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59
      UniProtKB/TrEMBL
      B4E3D9

    2. XM_054339809.1 → XP_054195784.1  cyclin-dependent kinase 11B isoform X5

      UniProtKB/TrEMBL
      B4E3D9

    3. XM_054339810.1 → XP_054195785.1  cyclin-dependent kinase 11B isoform X6

      UniProtKB/TrEMBL
      B4E3D9

    4. XM_054339807.1 → XP_054195782.1  cyclin-dependent kinase 11B isoform X3

      UniProtKB/TrEMBL
      B4E3D9

    5. XM_054339808.1 → XP_054195783.1  cyclin-dependent kinase 11B isoform X4

      UniProtKB/TrEMBL
      B4E3D9

    6. XM_054339802.1 → XP_054195777.1  cyclin-dependent kinase 11B isoform X1

      UniProtKB/TrEMBL
      B4E3D9

    7. XM_054339804.1 → XP_054195779.1  cyclin-dependent kinase 11B isoform X1

      UniProtKB/TrEMBL
      B4E3D9

    8. XM_054339803.1 → XP_054195778.1  cyclin-dependent kinase 11B isoform X1

      UniProtKB/TrEMBL
      B4E3D9

    9. XM_054339815.1 → XP_054195790.1  cyclin-dependent kinase 11B isoform X11

      UniProtKB/TrEMBL
      B4E3D9

    10. XM_054339806.1 → XP_054195781.1  cyclin-dependent kinase 11B isoform X2

      UniProtKB/Swiss-Prot
      B7ZVY7, J3KTL7, J3QR29, J3QR44, O95265, P21127, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59
      UniProtKB/TrEMBL
      B4E3D9

    11. XM_054339816.1 → XP_054195791.1  cyclin-dependent kinase 11B isoform X12

      UniProtKB/TrEMBL
      B4E3D9

    12. XM_054339814.1 → XP_054195789.1  cyclin-dependent kinase 11B isoform X10

      UniProtKB/TrEMBL
      Q5QPR4

    13. XM_054339813.1 → XP_054195788.1  cyclin-dependent kinase 11B isoform X9

      UniProtKB/TrEMBL
      Q5QPR4

    14. XM_054339812.1 → XP_054195787.1  cyclin-dependent kinase 11B isoform X8

      UniProtKB/TrEMBL
      Q5QPR4

    15. XM_054339811.1 → XP_054195786.1  cyclin-dependent kinase 11B isoform X7

      UniProtKB/TrEMBL
      Q5QPR4

    16. XM_054339818.1 → XP_054195793.1  cyclin-dependent kinase 11B isoform X14

      UniProtKB/TrEMBL
      A4VCI5

    17. XM_054339822.1 → XP_054195797.1  cyclin-dependent kinase 11B isoform X18

      UniProtKB/TrEMBL
      Q96CA8

    18. XM_054339817.1 → XP_054195792.1  cyclin-dependent kinase 11B isoform X13

    19. XM_054339821.1 → XP_054195796.1  cyclin-dependent kinase 11B isoform X17

      UniProtKB/TrEMBL
      J3KS35

    20. XM_054339820.1 → XP_054195795.1  cyclin-dependent kinase 11B isoform X16

    21. XM_054339819.1 → XP_054195794.1  cyclin-dependent kinase 11B isoform X15

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033488.1: Suppressed sequence

      Description
      NM_033488.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_033492.1: Suppressed sequence

      Description
      NM_033492.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    3. NM_033493.1: Suppressed sequence

      Description
      NM_033493.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21127.4 GenPept UniProtKB/Swiss-Prot:P21127

    Gene LinkOut

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