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    TLR4 toll like receptor 4 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 574360, updated on 17-Aug-2024

    Summary

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    Official Symbol
    TLR4provided by VGNC
    Official Full Name
    toll like receptor 4provided by VGNC
    Primary source
    VGNC:VGNC:78375
    Locus tag
    EGK_07381
    See related
    Ensembl:ENSMMUG00000009112
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    hToll
    Orthologs
    human mouse all
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    Genomic context

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    See TLR4 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (25088083..25105816, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (21608829..21625226, complement)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene translationally-controlled tumor protein Neighboring gene uncharacterized LOC106993624 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC114672628 Neighboring gene astrotactin 2 Neighboring gene tripartite motif containing 32

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased expression of TLR3 in lymph nodes during simian immunodeficiency virus infection: implications for inflammation and immunodeficiency. Sanghavi SK, et al. J Immunol, 2005 Oct 15. PMID 16210637
    2. Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions. Mothapo KM, et al. J Neurovirol, 2017 Apr. PMID 27882497
    3. Genetic analysis of Toll/Interleukin-1 Receptor (TIR) domain sequences from rhesus macaque Toll-like receptors (TLRs) 1-10 reveals high homology to human TLR/TIR sequences. Sanghavi SK, et al. Immunogenetics, 2004 Dec. PMID 15578265
    4. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Mandl JN, et al. Nat Med, 2008 Oct. PMID 18806803
    5. Natural selection in the TLR-related genes in the course of primate evolution. Nakajima T, et al. Immunogenetics, 2008 Dec. PMID 18810425

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cerebrospinal fluid soluble TLR2 and TLR4 may play a role in HIV/SIV-related neuroinflammation and subsequent neuropathology.
      Title: Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipopolysaccharide immune receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toll-like receptor 4
    NP_001032169.1
    XP_014972446.2
    XP_028690038.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037092.1 → NP_001032169.1  toll-like receptor 4 precursor

      See identical proteins and their annotated locations for NP_001032169.1

      Status: PROVISIONAL

      Source sequence(s)
      AB445644
      UniProtKB/TrEMBL
      A0A8J8XMT1, B3Y632, F7E9T3, F7HU26, G7NG29
      Related
      ENSMMUP00000039787.3, ENSMMUT00000046758.3
      Conserved Domains (7) summary
      smart00082
      Location:579 → 625
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:674 → 815
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:55 → 195
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:56 → 79
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:375 → 400
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:496 → 539
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:57 → 114
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      25088083..25105816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015116960.2 → XP_014972446.2  toll-like receptor 4 isoform X1

      UniProtKB/TrEMBL
      A0A5F8A174, Q3BBY2
      Related
      ENSMMUP00000071666.1, ENSMMUT00000084166.1
      Conserved Domains (6) summary
      smart00082
      Location:539 → 585
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:634 → 775
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:7 → 492
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00031
      Location:16 → 39
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:335 → 360
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:481 → 541
      LRR_8; Leucine rich repeat

    2. XM_028834205.1 → XP_028690038.1  toll-like receptor 4 isoform X2

      UniProtKB/TrEMBL
      B6CJZ2
      Conserved Domains (5) summary
      smart00082
      Location:379 → 425
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:474 → 615
      TIR; Toll - interleukin 1 - resistance
      PLN00113
      Location:152 → 332
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:175 → 200
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:321 → 381
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version

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