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    RAPGEF1 Rap guanine nucleotide exchange factor 1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 715272, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RAPGEF1provided by VGNC
    Official Full Name
    Rap guanine nucleotide exchange factor 1provided by VGNC
    Primary source
    VGNC:VGNC:76582
    See related
    Ensembl:ENSMMUG00000006479
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See RAPGEF1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 15 NC_041768.1 (8679452..8838334)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 15 NC_027907.1 (6803378..6935057)

    Chromosome 15 - NC_041768.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106993585 Neighboring gene uncharacterized LOC106993588 Neighboring gene uncharacterized LOC114672712 Neighboring gene proline rich transmembrane protein 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rap guanine nucleotide exchange factor 1
    Names
    Rap guanine nucleotide exchange factor (GEF) 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041768.1 Reference Mmul_10 Primary Assembly

      Range
      8679452..8838334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_028834702.1 → XP_028690535.1  rap guanine nucleotide exchange factor 1 isoform X8

      UniProtKB/TrEMBL
      F6XRX7
      Conserved Domains (5) summary
      smart00147
      Location:985 → 1214
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:837 → 978
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03169
      Location:677 → 844
      PHA03169; hypothetical protein; Provisional
      PHA03247
      Location:192 → 300
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:194 → 452
      PHA03307; transcriptional regulator ICP4; Provisional

    2. XM_028834699.1 → XP_028690532.1  rap guanine nucleotide exchange factor 1 isoform X2

      UniProtKB/TrEMBL
      F6XRX7, F7HBI2
      Related
      ENSMMUP00000008536.4, ENSMMUT00000009087.4
      Conserved Domains (5) summary
      smart00147
      Location:1023 → 1252
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:875 → 1016
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03169
      Location:715 → 882
      PHA03169; hypothetical protein; Provisional
      PHA03247
      Location:230 → 338
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:232 → 490
      PHA03307; transcriptional regulator ICP4; Provisional

    3. XM_028834703.1 → XP_028690536.1  rap guanine nucleotide exchange factor 1 isoform X12

      UniProtKB/TrEMBL
      F6XRX7
      Related
      ENSMMUP00000040043.3, ENSMMUT00000047013.3
      Conserved Domains (4) summary
      smart00147
      Location:853 → 1082
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:705 → 846
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03247
      Location:230 → 338
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:232 → 538
      PHA03307; transcriptional regulator ICP4; Provisional

    4. XM_028834700.1 → XP_028690533.1  rap guanine nucleotide exchange factor 1 isoform X4

      UniProtKB/TrEMBL
      F6XRX7
      Conserved Domains (5) summary
      smart00147
      Location:1008 → 1237
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:876 → 1020
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      PHA03169
      Location:716 → 883
      PHA03169; hypothetical protein; Provisional
      PHA03247
      Location:231 → 339
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:233 → 539
      PHA03307; transcriptional regulator ICP4; Provisional

    5. XM_015116520.2 → XP_014972006.1  rap guanine nucleotide exchange factor 1 isoform X1

      UniProtKB/TrEMBL
      F6XRX7
      Conserved Domains (2) summary
      smart00147
      Location:1024 → 1253
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:876 → 1017
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    6. XM_015116521.2 → XP_014972007.1  rap guanine nucleotide exchange factor 1 isoform X3

      UniProtKB/TrEMBL
      F6XRX7
      Conserved Domains (2) summary
      smart00147
      Location:1023 → 1252
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:875 → 1016
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    7. XM_015116525.2 → XP_014972011.1  rap guanine nucleotide exchange factor 1 isoform X7

      UniProtKB/TrEMBL
      F6XRX7
      Conserved Domains (2) summary
      smart00147
      Location:986 → 1215
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:838 → 979
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    8. XM_015116522.2 → XP_014972008.1  rap guanine nucleotide exchange factor 1 isoform X5

      UniProtKB/TrEMBL
      F6XRX7
      Conserved Domains (2) summary
      smart00147
      Location:993 → 1222
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:845 → 986
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    9. XM_015116524.2 → XP_014972010.1  rap guanine nucleotide exchange factor 1 isoform X6

      UniProtKB/TrEMBL
      F6XRX7
      Conserved Domains (2) summary
      smart00147
      Location:992 → 1221
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:844 → 985
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    10. XM_015116526.2 → XP_014972012.1  rap guanine nucleotide exchange factor 1 isoform X9

      UniProtKB/TrEMBL
      F6XRX7
      Conserved Domains (2) summary
      smart00147
      Location:907 → 1136
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:759 → 900
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    11. XM_015116527.2 → XP_014972013.1  rap guanine nucleotide exchange factor 1 isoform X10

      UniProtKB/TrEMBL
      F6XRX7
      Conserved Domains (2) summary
      smart00147
      Location:906 → 1135
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:758 → 899
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    12. XM_015116528.2 → XP_014972014.1  rap guanine nucleotide exchange factor 1 isoform X11

      UniProtKB/TrEMBL
      F6XRQ1, G7NFI0, H9Z804
      Related
      ENSMMUP00000040047.3, ENSMMUT00000047017.3
      Conserved Domains (2) summary
      smart00147
      Location:854 → 1083
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:706 → 847
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    Nucleotide Protein
    Heading Accession and Version

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