Mcfd2 multiple coagulation factor deficiency 2, ER cargo receptor complex subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mcfd2provided by RGD
Official Full Name: multiple coagulation factor deficiency 2, ER cargo receptor complex subunitprovided by RGD
Primary source: RGD:628690
See related: EnsemblRapid:ENSRNOG00000015059 AllianceGenome:RGD:628690
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sdnsf
Summary: Predicted to enable calcium ion binding activity. Involved in brain development and negative regulation of cell death. Acts upstream of or within carboxylic acid metabolic process. Located in extracellular region. Biomarker of transient cerebral ischemia. Orthologous to human MCFD2 (multiple coagulation factor deficiency 2, ER cargo receptor complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1098.5), Adrenal (RPKM 401.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (13028036..13039388)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (7274469..7285841)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (10887303..10899221, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SDNSF is expressed in the gray matter of spinal cord. The expression of SDNSF mRNA in the spinal cord varies with injured time. (2) The nestin-positive cells proliferate accompanied with spinal cord injury repair, but do not secrete SDNSF.
Title: Expression change of stem cell-derived neural stem/progenitor cell supporting factor gene in injured spinal cord of rats.
role as an autocrine/paracrine factor in maintaining stem cell potential and lifelong neurogenesis in adult central nervous system
Title: Stem cell-derived neural stem/progenitor cell supporting factor is an autocrine/paracrine survival factor for adult neural stem/progenitor cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carboxylic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: multiple coagulation factor deficiency protein 2 homolog

Names: neural stem cell-derived neuronal survival protein; stem cell derived neuronal survival protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139253.2 → NP_640346.2 multiple coagulation factor deficiency protein 2 homolog precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q8K5B3

UniProtKB/TrEMBL

A0A0G2JWG5, Q6GQY2

Related

ENSRNOP00000069872.1, ENSRNOT00000089104.3

Conserved Domains (1) summary

pfam13499
Location:76 → 142

EF-hand_7; EF-hand domain pair