LATS2 large tumor suppressor kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LATS2provided by HGNC
Official Full Name: large tumor suppressor kinase 2provided by HGNC
Primary source: HGNC:HGNC:6515
See related: Ensembl:ENSG00000150457 MIM:604861; AllianceGenome:HGNC:6515
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KPM
Summary: This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 10.9), gall bladder (RPKM 10.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q12.11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (20973036..21061586, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (20166164..20254674, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (21547175..21635725, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
Title: A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2.
Title: MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2.
RNF106 aggravates esophageal squamous cell carcinoma progression through LATS2/YAP axis.
Title: RNF106 aggravates esophageal squamous cell carcinoma progression through LATS2/YAP axis.
Mir-629 Repressed LATS2 Expression and Promoted the Proliferation of Prostate Cancer Cells.
Title: Mir-629 Repressed LATS2 Expression and Promoted the Proliferation of Prostate Cancer Cells.
FBXO22 Accelerates Pancreatic Cancer Growth by Deactivation of the Hippo Pathway via Destabilizing LATS2.
Title: FBXO22 Accelerates Pancreatic Cancer Growth by Deactivation of the Hippo Pathway via Destabilizing LATS2.
The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation regulates angiogenesis and liver metastasis in colorectal cancer.
Title: The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation regulates angiogenesis and liver metastasis in colorectal cancer.
circPKD2 inhibits the glioma cell proliferation, invasion and glycolytic metabolism through regulating the miR-1278/LATS2 axis.
Title: circPKD2 inhibits the glioma cell proliferation, invasion and glycolytic metabolism through regulating the miR-1278/LATS2 axis.
Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.
Title: Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.
LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells.
Title: LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells.
Deathly triangle for pancreatic beta-cells: Hippo pathway-MTORC1-autophagy.
Title: Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy.

Submit: New GeneRIF Correction See all GeneRIFs (138)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-33925 (e-PCR)
- UniSTS:25674

L18426 (e-PCR)
- UniSTS:34648

D1S1423 (e-PCR)
- UniSTS:149619

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in hippo signaling	TAS Traceable Author Statement more info
involved_in hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in inner cell mass cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in inner cell mass cellular morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IDA Inferred from Direct Assay more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase LATS2

Names: LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 2; kinase phosphorylated during mitosis protein; large tumor suppressor homolog 2; serine/threonine kinase KPM; serine/threonine-protein kinase kpm; warts-like kinase

NP_055387.2

EC 2.7.11.1

XP_005266399.1

EC 2.7.11.1

XP_011533344.1

EC 2.7.11.1

XP_016876030.1

EC 2.7.11.1

XP_016876031.1

EC 2.7.11.1

XP_047286222.1

EC 2.7.11.1

XP_047286223.1

EC 2.7.11.1

XP_054230417.1

EC 2.7.11.1

XP_054230418.1

EC 2.7.11.1

XP_054230419.1

EC 2.7.11.1

XP_054230420.1

EC 2.7.11.1

XP_054230421.1

EC 2.7.11.1

XP_054230422.1

EC 2.7.11.1

XP_054230423.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014572.3 → NP_055387.2 serine/threonine-protein kinase LATS2

See identical proteins and their annotated locations for NP_055387.2

Status: REVIEWED

Source sequence(s)

AF207547, AL161613, AL356285, BQ774580, DB452765

Consensus CDS

CCDS9294.1

UniProtKB/Swiss-Prot

B1AM47, Q9NRM7, Q9P2X1

UniProtKB/TrEMBL

Q59EB4

Related

ENSP00000372035.4, ENST00000382592.5

Conserved Domains (3) summary

cd05626
Location:666 → 1046

STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2

smart00220
Location:668 → 973

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14398
Location:101 → 141

UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000013.11 Reference GRCh38.p14 Primary Assembly

Range

20973036..21061586 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017020542.2 → XP_016876031.1 serine/threonine-protein kinase LATS2 isoform X4

UniProtKB/TrEMBL

Q59EB4
XM_005266342.1 → XP_005266399.1 serine/threonine-protein kinase LATS2 isoform X1

See identical proteins and their annotated locations for XP_005266399.1

UniProtKB/Swiss-Prot

B1AM47, Q9NRM7, Q9P2X1

UniProtKB/TrEMBL

Q59EB4

Conserved Domains (3) summary

cd05626
Location:666 → 1046

STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2

smart00220
Location:668 → 973

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14398
Location:101 → 141

UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
XM_047430266.1 → XP_047286222.1 serine/threonine-protein kinase LATS2 isoform X1

UniProtKB/Swiss-Prot

B1AM47, Q9NRM7, Q9P2X1
XM_047430267.1 → XP_047286223.1 serine/threonine-protein kinase LATS2 isoform X4
XM_017020541.2 → XP_016876030.1 serine/threonine-protein kinase LATS2 isoform X3

UniProtKB/TrEMBL

Q59EB4
XM_011535042.3 → XP_011533344.1 serine/threonine-protein kinase LATS2 isoform X2

Conserved Domains (3) summary

cd05626
Location:579 → 959

STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2

smart00220
Location:581 → 886

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21463
Location:24 → 54

UBA_like_SF; UBA domain-like superfamily

Alternate T2T-CHM13v2.0

Genomic

NC_060937.1 Alternate T2T-CHM13v2.0

Range

20166164..20254674 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054374447.1 → XP_054230422.1 serine/threonine-protein kinase LATS2 isoform X4
XM_054374443.1 → XP_054230418.1 serine/threonine-protein kinase LATS2 isoform X1
XM_054374444.1 → XP_054230419.1 serine/threonine-protein kinase LATS2 isoform X1
XM_054374448.1 → XP_054230423.1 serine/threonine-protein kinase LATS2 isoform X4
XM_054374442.1 → XP_054230417.1 serine/threonine-protein kinase LATS2 isoform X1
XM_054374446.1 → XP_054230421.1 serine/threonine-protein kinase LATS2 isoform X3
XM_054374445.1 → XP_054230420.1 serine/threonine-protein kinase LATS2 isoform X2