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    IKZF1 IKAROS family zinc finger 1 [ Homo sapiens (human) ]

    Gene ID: 10320, updated on 26-Nov-2024

    Summary

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    Official Symbol
    IKZF1provided by HGNC
    Official Full Name
    IKAROS family zinc finger 1provided by HGNC
    Primary source
    HGNC:HGNC:13176
    See related
    Ensembl:ENSG00000185811 MIM:603023; AllianceGenome:HGNC:13176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452
    Summary
    This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
    Expression
    Biased expression in lymph node (RPKM 13.3), appendix (RPKM 8.6) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IKZF1 in Genome Data Viewer
    Location:
    7p12.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (50303455..50405101)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (50464429..50566317)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (50343660..50472799)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901630 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18176 Neighboring gene sperm microtubule inner protein 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50246159-50247088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50251182-50251682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50251683-50252183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50342269-50342770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50354096-50354596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50356151-50356651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25999 Neighboring gene conserved acetylation island sequence 3 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:50427949-50428468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:50428469-50428986 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:50446466-50446972 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:50446973-50447478 Neighboring gene uncharacterized LOC124901631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:50477534-50478034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26005 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26007 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:50488572-50489105 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:50514049-50515248 Neighboring gene Sharpr-MPRA regulatory region 9826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18183 Neighboring gene RNA, U6 small nuclear 1091, pseudogene Neighboring gene fidgetin like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Ikaros (IKZF1) alterations and minimal residual disease at day 15 assessed by flow cytometry predict prognosis of childhood BCR/ABL-negative acute lymphoblastic leukemia. Volejnikova J, et al. Pediatr Blood Cancer, 2013 Mar. PMID 22997141
    2. Microdeletion of 7p12.1p13, including IKZF1, causes intellectual impairment, overgrowth, and susceptibility to leukaemia. Järviaho T, et al. Br J Haematol, 2019 Apr. PMID 30004112
    3. Immunomodulatory drugs downregulate IKZF1 leading to expansion of hematopoietic progenitors with concomitant block of megakaryocytic maturation. Liu A, et al. Haematologica, 2018 Oct. PMID 29954930, Free PMC Article
    4. Ikaros family zinc-finger 1 mutation is an independent factor for the poor prognosis of adult B-cell acute lymphoblastic leukemia, and allogeneic hematopoietic stem cell transplantation can improve clinical outcomes. Tang S, et al. Bone Marrow Transplant, 2019 Feb. PMID 29942002
    5. IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol. Dörge P, et al. Haematologica, 2013 Mar. PMID 22875627, Free PMC Article

    See all (395) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity.
      Title: Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity.
    2. IgG4-related disease and B-cell malignancy due to an IKZF1 gain-of-function variant.
      Title: IgG4-related disease and B-cell malignancy due to an IKZF1 gain-of-function variant.
    3. IKZF1[PLUS] alterations contribute to outcome disparities in Hispanic/Latino children with B-lymphoblastic leukemia.
      Title: IKZF1(PLUS) alterations contribute to outcome disparities in Hispanic/Latino children with B-lymphoblastic leukemia.
    4. CCL2 mediated IKZF1 expression promotes M2 polarization of glioma-associated macrophages through CD84-SHP2 pathway.
      Title: CCL2 mediated IKZF1 expression promotes M2 polarization of glioma-associated macrophages through CD84-SHP2 pathway.
    5. IKZF1 and UBR4 gene variants drive autoimmunity and Th2 polarization in IgG4-related disease.
      Title: IKZF1 and UBR4 gene variants drive autoimmunity and Th2 polarization in IgG4-related disease.
    6. The GWAS SNP rs80207740 modulates erythrocyte traits via allele-specific binding of IKZF1 and targeting XPO7 gene.
      Title: The GWAS SNP rs80207740 modulates erythrocyte traits via allele-specific binding of IKZF1 and targeting XPO7 gene.
    7. Loss-of-phosphorylation of IKZF1 results in gain-of-function associated with immune dysregulation.
      Title: Loss-of-phosphorylation of IKZF1 results in gain-of-function associated with immune dysregulation.
    8. A novel IKZF1 variant in a family with autosomal dominant CVID: A case for expanding exon coverage in inborn errors of immunity.
      Title: A novel IKZF1 variant in a family with autosomal dominant CVID: A case for expanding exon coverage in inborn errors of immunity.
    9. IKZF1 rs4132601 and rs11978267 gene polymorphisms and paediatric systemic lupus erythematosus; relation to lupus nephritis.
      Title: IKZF1 rs4132601 and rs11978267 gene polymorphisms and paediatric systemic lupus erythematosus; relation to lupus nephritis.
    10. A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children.
      Title: A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children.
    Submit: New GeneRIF Correction See all GeneRIFs (301)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Pancytopenia due to IKZF1 mutations
    MedGen: C4225173 OMIM: 616873 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Confirmation of Childhood Acute Lymphoblastic Leukemia Variants, ARID5B and IKZF1, and Interaction with Parental Environmental Exposures.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Germline genomic variants associated with childhood acute lymphoblastic leukemia.
    EBI GWAS Catalog
    Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog
    Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.
    EBI GWAS Catalog
    Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
    EBI GWAS Catalog
    Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
    EBI GWAS Catalog
    Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
    EBI GWAS Catalog
    Seventy-five genetic loci influencing the human red blood cell.
    EBI GWAS Catalog
    Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Ikaros is identified to interact with HIV-1 Tat in Jurkat cell by GST pull-down and by WB PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lymphocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding protein Ikaros
    Names
    CLL-associated antigen KW-6
    ikaros family zinc finger protein 1
    lymphoid transcription factor LyF-1
    protein phosphatase 1, regulatory subunit 92
    zinc finger protein, subfamily 1A, 1 (Ikaros)

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034231.1 RefSeqGene

      Range
      5634..106019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1121

    mRNA and Protein(s)

    1. NM_001220765.3 → NP_001207694.1  DNA-binding protein Ikaros isoform 2

      See identical proteins and their annotated locations for NP_001207694.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2, also known as Ikx) is shorter than isoform 1, and it contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:11489963). Both variants 2 and 14 encode isoform 2.
      Source sequence(s)
      AY377974, BC018349, BM148203, JX459579
      Consensus CDS
      CCDS59055.1
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Related
      ENSP00000352123.5, ENST00000359197.9
      Conserved Domains (2) summary
      sd00017
      Location:119 → 139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132 → 156
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001220767.2 → NP_001207696.1  DNA-binding protein Ikaros isoform 4

      See identical proteins and their annotated locations for NP_001207696.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (4, also known as Ik-2(del) as described in PMID:9892693) is shorter than isoform 1. This isoform contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/TrEMBL
      A0A8V8TMF3
      Conserved Domains (2) summary
      COG5048
      Location:1 → 131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001220768.2 → NP_001207697.1  DNA-binding protein Ikaros isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (5, also known as Ik-3 as described in PMID:12937159) is shorter than isoform 1. This isoform contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Conserved Domains (2) summary
      sd00017
      Location:119 → 139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132 → 156
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001220770.2 → NP_001207699.1  DNA-binding protein Ikaros isoform 7

      See identical proteins and their annotated locations for NP_001207699.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon in both the 5' and central coding regions, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (7, also known as Ik-4(del) as described in PMID:9892693), is shorter than isoform 1. This isoform contains only two N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/TrEMBL
      A0A8V8TMF3
      Conserved Domains (4) summary
      COG5048
      Location:1 → 112
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:58 → 80
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:72 → 97
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001220771.2 → NP_001207700.1  DNA-binding protein Ikaros isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks three consecutive alternate in-frame exons in the central coding region, compared to variant 1. The encoded isoform (8, also known as Ik-5 as described in PMID:12937159) is shorter than isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant-negative isoform.
      Source sequence(s)
      BC018349, JX459579
      Consensus CDS
      CCDS69299.1
      UniProtKB/TrEMBL
      A0A8V8TMF3
      Related
      ENSP00000513806.1, ENST00000698575.1

    6. NM_001291837.2 → NP_001278766.1  DNA-binding protein Ikaros isoform 2

      See identical proteins and their annotated locations for NP_001278766.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2, also known as Ikx) is shorter than isoform 1, and it contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:11489963). Both variants 2 and 14 encode isoform 2.
      Source sequence(s)
      BC018349, DB122945, JX459579
      Consensus CDS
      CCDS59055.1
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Related
      ENSP00000413025.1, ENST00000439701.2
      Conserved Domains (2) summary
      sd00017
      Location:119 → 139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132 → 156
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001291838.2 → NP_001278767.1  DNA-binding protein Ikaros isoform 3

      See identical proteins and their annotated locations for NP_001278767.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-2) differs in the 5' UTR, and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (3, also known as Ik-2) is shorter than isoform 1, and is localized to the nucleus and contains three N-terminal zinc finger motifs for high affinity DNA binding (PMID:9892693).
      Source sequence(s)
      AK303586, DB122945, JX459579
      Consensus CDS
      CCDS78233.1
      UniProtKB/Swiss-Prot
      Q13422
      UniProtKB/TrEMBL
      R9R4D9
      Related
      ENSP00000396554.1, ENST00000438033.5
      Conserved Domains (2) summary
      COG5048
      Location:1 → 131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001291839.2 → NP_001278768.1  DNA-binding protein Ikaros isoform 6

      See identical proteins and their annotated locations for NP_001278768.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-4) differs in the 5' UTR, and lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1. The encoded isoform (6, also known as Ik-4 as described in PMID:12937159), is shorter than isoform 1. This isoform contains only two N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
      Source sequence(s)
      AC233268, BC018349, DC391353, JX459579
      UniProtKB/TrEMBL
      A0A8V8TMF3
      Conserved Domains (4) summary
      COG5048
      Location:1 → 112
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:58 → 80
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:72 → 97
      zf-H2C2_2; Zinc-finger double domain

    9. NM_001291840.1 → NP_001278769.1  DNA-binding protein Ikaros isoform Ik-6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-6) lacks four consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Ik-6) is shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs, is localized to the cytoplasm and functions as a non-DNA-binding, dominant-negative isoform (PMIDs:12937159, 10463586).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/TrEMBL
      A0A0A0MRA0

    10. NM_001291841.1 → NP_001278770.1  DNA-binding protein Ikaros isoform Ik-7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-7) lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Ik-7) is shorter than isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/TrEMBL
      A0A087WU46
      Related
      ENSP00000478368.1, ENST00000615491.4
      Conserved Domains (1) summary
      sd00017
      Location:60 → 81
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. NM_001291842.1 → NP_001278771.1  DNA-binding protein Ikaros isoform Ik-7(del)

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-7(del)) lacks two consecutive in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (Ik-7(del)) is shorter than isoform 1. This isoform contains only one N-terminal zinc finger motif, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/TrEMBL
      A0A087WU46
      Conserved Domains (1) summary
      sd00017
      Location:60 → 81
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. NM_001291843.1 → NP_001278772.1  DNA-binding protein Ikaros isoform Ik-8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-8) lacks three consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Ik-8) is shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/TrEMBL
      A0A087WU46

    13. NM_001291844.1 → NP_001278773.1  DNA-binding protein Ikaros isoform Ik-8(del)

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Ik-8(del)) lacks three consecutive in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (Ik-8(del)) is shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs, and represents a non-DNA-binding, dominant-negative isoform (PMID:9892693).
      Source sequence(s)
      JX459579, U40462
      UniProtKB/TrEMBL
      A0A087WU46

    14. NM_001291845.2 → NP_001278774.1  DNA-binding protein Ikaros isoform 15

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) lacks five 3' exons but contains an alternate 3' terminal exon, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (15) has a distinct C-terminus and is significantly shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs and is likely non-DNA-binding.
      Source sequence(s)
      AC124014, BC064594, DB148957
      Consensus CDS
      CCDS78232.1
      UniProtKB/TrEMBL
      C9JTB0
      Related
      ENSP00000388478.1, ENST00000413698.5

    15. NM_001291846.2 → NP_001278775.1  DNA-binding protein Ikaros isoform 16

      See identical proteins and their annotated locations for NP_001278775.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) lacks five 3' exons but contains two alternate 3' exons, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (16) has a distinct C-terminus and is significantly shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs and is likely non-DNA-binding. Both variants 16 and 17 encode isoform 16.
      Source sequence(s)
      AW337855, BM148203, BU537824
      Consensus CDS
      CCDS87502.1
      UniProtKB/TrEMBL
      A0A2R8Y4D3
      Related
      ENSP00000493696.1, ENST00000646110.1

    16. NM_001291847.2 → NP_001278776.1  DNA-binding protein Ikaros isoform 16

      See identical proteins and their annotated locations for NP_001278776.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) differs in the 5' UTR, and lacks five 3' exons but contains two alternate 3' exons, and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (16) has a distinct C-terminus and is significantly shorter than isoform 1. This isoform contains no N-terminal zinc finger motifs and is likely non-DNA-binding. Both variants 16 and 17 encode isoform 16.
      Source sequence(s)
      AW337855, BU537824, DB122945
      Consensus CDS
      CCDS87502.1
      UniProtKB/TrEMBL
      A0A2R8Y4D3
      Related
      ENSP00000494180.1, ENST00000492782.6

    17. NM_001410879.1 → NP_001397808.1  DNA-binding protein Ikaros isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC124014, AC233268
      Consensus CDS
      CCDS94102.1
      UniProtKB/TrEMBL
      A0A8V8TNQ0

    18. NM_006060.6 → NP_006051.1  DNA-binding protein Ikaros isoform 1

      See identical proteins and their annotated locations for NP_006051.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1 (also known as Ik-1 as described in PMID:12937159). This isoform contains four N-terminal zinc finger motifs, binds DNA, and is localized to the nucleus.
      Source sequence(s)
      BM148203, JX459579, U40462
      Consensus CDS
      CCDS75596.1
      UniProtKB/Swiss-Prot
      A4D260, B4E0Z1, D3DVM5, O00598, Q13422, Q53XL2, Q69BM4, Q8WVA3
      Related
      ENSP00000331614.3, ENST00000331340.8
      Conserved Domains (2) summary
      sd00017
      Location:119 → 139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132 → 156
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      50303455..50405101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515058.3 → XP_011513360.1  DNA-binding protein Ikaros isoform X1

      See identical proteins and their annotated locations for XP_011513360.1

      Conserved Domains (3) summary
      COG5048
      Location:187 → 343
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:163 → 183
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:176 → 200
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011515059.4 → XP_011513361.1  DNA-binding protein Ikaros isoform X2

      See identical proteins and their annotated locations for XP_011513361.1

      Conserved Domains (3) summary
      COG5048
      Location:187 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:163 → 183
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:176 → 200
      zf-H2C2_2; Zinc-finger double domain

    3. XM_011515067.4 → XP_011513369.1  DNA-binding protein Ikaros isoform X8

      See identical proteins and their annotated locations for XP_011513369.1

      Conserved Domains (2) summary
      sd00017
      Location:163 → 183
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:176 → 200
      zf-H2C2_2; Zinc-finger double domain

    4. XM_047419727.1 → XP_047275683.1  DNA-binding protein Ikaros isoform X10

    5. XM_011515071.3 → XP_011513373.1  DNA-binding protein Ikaros isoform X17

      See identical proteins and their annotated locations for XP_011513373.1

      Conserved Domains (4) summary
      COG5048
      Location:101 → 175
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:104 → 124
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:102 → 124
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:116 → 141
      zf-H2C2_2; Zinc-finger double domain

    6. XM_047419739.1 → XP_047275695.1  DNA-binding protein Ikaros isoform X19

    7. XM_011515061.4 → XP_011513363.1  DNA-binding protein Ikaros isoform X4

      See identical proteins and their annotated locations for XP_011513363.1

      Conserved Domains (3) summary
      COG5048
      Location:167 → 323
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:143 → 163
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156 → 180
      zf-H2C2_2; Zinc-finger double domain

    8. XM_047419723.1 → XP_047275679.1  DNA-binding protein Ikaros isoform X6

    9. XM_011515070.3 → XP_011513372.1  DNA-binding protein Ikaros isoform X12

      See identical proteins and their annotated locations for XP_011513372.1

      Conserved Domains (2) summary
      sd00017
      Location:143 → 163
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156 → 180
      zf-H2C2_2; Zinc-finger double domain

    10. XM_047419731.1 → XP_047275687.1  DNA-binding protein Ikaros isoform X14

    11. XM_011515072.3 → XP_011513374.1  DNA-binding protein Ikaros isoform X20

      See identical proteins and their annotated locations for XP_011513374.1

      Conserved Domains (2) summary
      COG5048
      Location:25 → 155
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:84 → 104
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. XM_011515074.3 → XP_011513376.1  DNA-binding protein Ikaros isoform X23

      See identical proteins and their annotated locations for XP_011513376.1

      Conserved Domains (2) summary
      COG5048
      Location:25 → 155
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:84 → 104
      ZF_C2H2; C2H2 Zn finger [structural motif]

    13. XM_011515077.3 → XP_011513379.1  DNA-binding protein Ikaros isoform X27

      See identical proteins and their annotated locations for XP_011513379.1

      UniProtKB/TrEMBL
      A0A8V8TMF3
      Conserved Domains (4) summary
      COG5048
      Location:25 → 136
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:84 → 104
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:82 → 104
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:96 → 121
      zf-H2C2_2; Zinc-finger double domain

    14. XM_011515078.3 → XP_011513380.1  DNA-binding protein Ikaros isoform X29

      See identical proteins and their annotated locations for XP_011513380.1

      UniProtKB/TrEMBL
      A0A8V8TMF3
      Conserved Domains (4) summary
      COG5048
      Location:25 → 136
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:84 → 104
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:82 → 104
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:96 → 121
      zf-H2C2_2; Zinc-finger double domain

    15. XM_047419726.1 → XP_047275682.1  DNA-binding protein Ikaros isoform X9

      UniProtKB/Swiss-Prot
      A4D260, B4E0Z1, D3DVM5, O00598, Q13422, Q53XL2, Q69BM4, Q8WVA3

    16. XM_047419729.1 → XP_047275685.1  DNA-binding protein Ikaros isoform X11

    17. XM_047419734.1 → XP_047275690.1  DNA-binding protein Ikaros isoform X16

    18. XM_047419736.1 → XP_047275692.1  DNA-binding protein Ikaros isoform X18

    19. XM_047419745.1 → XP_047275701.1  DNA-binding protein Ikaros isoform X25

    20. XM_047419747.1 → XP_047275703.1  DNA-binding protein Ikaros isoform X26

    21. XM_011515063.3 → XP_011513365.1  DNA-binding protein Ikaros isoform X5

      See identical proteins and their annotated locations for XP_011513365.1

      UniProtKB/TrEMBL
      A0A8V8TNQ0
      Related
      ENSP00000513805.1, ENST00000698574.1
      Conserved Domains (2) summary
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152 → 176
      zf-H2C2_2; Zinc-finger double domain

    22. XM_047419744.1 → XP_047275700.1  DNA-binding protein Ikaros isoform X24

    23. XM_047419735.1 → XP_047275691.1  DNA-binding protein Ikaros isoform X18

    24. XM_011515065.3 → XP_011513367.1  DNA-binding protein Ikaros isoform X5

      See identical proteins and their annotated locations for XP_011513367.1

      UniProtKB/TrEMBL
      A0A8V8TNQ0
      Conserved Domains (2) summary
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152 → 176
      zf-H2C2_2; Zinc-finger double domain

    25. XM_047419724.1 → XP_047275680.1  DNA-binding protein Ikaros isoform X7

    26. XM_047419730.1 → XP_047275686.1  DNA-binding protein Ikaros isoform X13

      Conserved Domains (2) summary
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152 → 176
      zf-H2C2_2; Zinc-finger double domain

    27. XM_047419732.1 → XP_047275688.1  DNA-binding protein Ikaros isoform X15

    28. XM_047419740.1 → XP_047275696.1  DNA-binding protein Ikaros isoform X21

      UniProtKB/TrEMBL
      A0A2R8YFR0
      Related
      ENSP00000496655.2, ENST00000642219.2

    29. XM_047419725.1 → XP_047275681.1  DNA-binding protein Ikaros isoform X9

      UniProtKB/Swiss-Prot
      A4D260, B4E0Z1, D3DVM5, O00598, Q13422, Q53XL2, Q69BM4, Q8WVA3

    30. XM_047419728.1 → XP_047275684.1  DNA-binding protein Ikaros isoform X11

    31. XM_047419733.1 → XP_047275689.1  DNA-binding protein Ikaros isoform X16

    32. XM_047419738.1 → XP_047275694.1  DNA-binding protein Ikaros isoform X18

    33. XM_017011668.2 → XP_016867157.1  DNA-binding protein Ikaros isoform X25

      UniProtKB/Swiss-Prot
      Q13422
      Conserved Domains (2) summary
      COG5048
      Location:1 → 131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]

    34. XM_047419746.1 → XP_047275702.1  DNA-binding protein Ikaros isoform X26

    35. XM_047419750.1 → XP_047275706.1  DNA-binding protein Ikaros isoform X31

      Related
      ENSP00000513804.1, ENST00000698573.1

    36. XM_011515062.3 → XP_011513364.1  DNA-binding protein Ikaros isoform X5

      See identical proteins and their annotated locations for XP_011513364.1

      UniProtKB/TrEMBL
      A0A8V8TNQ0
      Conserved Domains (2) summary
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152 → 176
      zf-H2C2_2; Zinc-finger double domain

    37. XM_011515073.3 → XP_011513375.1  DNA-binding protein Ikaros isoform X21

      UniProtKB/TrEMBL
      A0A2R8YFR0
      Conserved Domains (3) summary
      sd00017
      Location:80 → 100
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:78 → 100
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:92 → 117
      zf-H2C2_2; Zinc-finger double domain

    38. XM_047419748.1 → XP_047275704.1  DNA-binding protein Ikaros isoform X28

    39. XM_011515064.4 → XP_011513366.1  DNA-binding protein Ikaros isoform X5

      See identical proteins and their annotated locations for XP_011513366.1

      UniProtKB/TrEMBL
      A0A8V8TNQ0
      Conserved Domains (2) summary
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152 → 176
      zf-H2C2_2; Zinc-finger double domain

    40. XM_011515060.3 → XP_011513362.1  DNA-binding protein Ikaros isoform X3

      See identical proteins and their annotated locations for XP_011513362.1

      Conserved Domains (2) summary
      sd00017
      Location:149 → 169
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:162 → 186
      zf-H2C2_2; Zinc-finger double domain

    41. XM_047419749.1 → XP_047275705.1  DNA-binding protein Ikaros isoform X30

      Conserved Domains (4) summary
      COG5048
      Location:2 → 122
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:70 → 90
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:68 → 90
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:82 → 107
      zf-H2C2_2; Zinc-finger double domain

    42. XM_047419741.1 → XP_047275697.1  DNA-binding protein Ikaros isoform X22

    43. XM_047419742.1 → XP_047275698.1  DNA-binding protein Ikaros isoform X22

    44. XM_047419743.1 → XP_047275699.1  DNA-binding protein Ikaros isoform X22

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      50464429..50566317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357028.1 → XP_054213003.1  DNA-binding protein Ikaros isoform X20

    2. XM_054357009.1 → XP_054212984.1  DNA-binding protein Ikaros isoform X6

    3. XM_054357041.1 → XP_054213016.1  DNA-binding protein Ikaros isoform X29

    4. XM_054357014.1 → XP_054212989.1  DNA-binding protein Ikaros isoform X10

    5. XM_054357027.1 → XP_054213002.1  DNA-binding protein Ikaros isoform X19

    6. XM_054357019.1 → XP_054212994.1  DNA-binding protein Ikaros isoform X14

    7. XM_054357011.1 → XP_054212986.1  DNA-binding protein Ikaros isoform X13

    8. XM_054357039.1 → XP_054213014.1  DNA-binding protein Ikaros isoform X32

    9. XM_054357002.1 → XP_054212977.1  DNA-binding protein Ikaros isoform X7

    10. XM_054357033.1 → XP_054213008.1  DNA-binding protein Ikaros isoform X26

    11. XM_054357017.1 → XP_054212992.1  DNA-binding protein Ikaros isoform X16

    12. XM_054357023.1 → XP_054212998.1  DNA-binding protein Ikaros isoform X21

      UniProtKB/TrEMBL
      A0A2R8YFR0

    13. XM_054357001.1 → XP_054212976.1  DNA-binding protein Ikaros isoform X5

      UniProtKB/TrEMBL
      A0A8V8TNQ0

    14. XM_054357004.1 → XP_054212979.1  DNA-binding protein Ikaros isoform X9

      UniProtKB/Swiss-Prot
      A4D260, B4E0Z1, D3DVM5, O00598, Q13422, Q53XL2, Q69BM4, Q8WVA3

    15. XM_054357005.1 → XP_054212980.1  DNA-binding protein Ikaros isoform X5

      UniProtKB/TrEMBL
      A0A8V8TNQ0

    16. XM_054357010.1 → XP_054212985.1  DNA-binding protein Ikaros isoform X7

    17. XM_054357018.1 → XP_054212993.1  DNA-binding protein Ikaros isoform X13

    18. XM_054357020.1 → XP_054212995.1  DNA-binding protein Ikaros isoform X15

    19. XM_054357029.1 → XP_054213004.1  DNA-binding protein Ikaros isoform X21

      UniProtKB/TrEMBL
      A0A2R8YFR0

    20. XM_054357012.1 → XP_054212987.1  DNA-binding protein Ikaros isoform X9

      UniProtKB/Swiss-Prot
      A4D260, B4E0Z1, D3DVM5, O00598, Q13422, Q53XL2, Q69BM4, Q8WVA3

    21. XM_054357015.1 → XP_054212990.1  DNA-binding protein Ikaros isoform X11

    22. XM_054357021.1 → XP_054212996.1  DNA-binding protein Ikaros isoform X16

    23. XM_054357026.1 → XP_054213001.1  DNA-binding protein Ikaros isoform X18

    24. XM_054357035.1 → XP_054213010.1  DNA-binding protein Ikaros isoform X25

    25. XM_054357037.1 → XP_054213012.1  DNA-binding protein Ikaros isoform X26

    26. XM_054357043.1 → XP_054213018.1  DNA-binding protein Ikaros isoform X31

    27. XM_054357025.1 → XP_054213000.1  DNA-binding protein Ikaros isoform X18

    28. XM_054357024.1 → XP_054212999.1  DNA-binding protein Ikaros isoform X18

    29. XM_054357034.1 → XP_054213009.1  DNA-binding protein Ikaros isoform X24

    30. XM_054357038.1 → XP_054213013.1  DNA-binding protein Ikaros isoform X26

    31. XM_054357016.1 → XP_054212991.1  DNA-binding protein Ikaros isoform X11

    32. XM_054357022.1 → XP_054212997.1  DNA-binding protein Ikaros isoform X16

    33. XM_054357008.1 → XP_054212983.1  DNA-binding protein Ikaros isoform X5

      UniProtKB/TrEMBL
      A0A8V8TNQ0

    34. XM_054357036.1 → XP_054213011.1  DNA-binding protein Ikaros isoform X25

    35. XM_054357013.1 → XP_054212988.1  DNA-binding protein Ikaros isoform X9

      UniProtKB/Swiss-Prot
      A4D260, B4E0Z1, D3DVM5, O00598, Q13422, Q53XL2, Q69BM4, Q8WVA3

    36. XM_054357006.1 → XP_054212981.1  DNA-binding protein Ikaros isoform X5

      UniProtKB/TrEMBL
      A0A8V8TNQ0

    37. XM_054357030.1 → XP_054213005.1  DNA-binding protein Ikaros isoform X21

      UniProtKB/TrEMBL
      A0A2R8YFR0

    38. XM_054357040.1 → XP_054213015.1  DNA-binding protein Ikaros isoform X28

    39. XM_054357007.1 → XP_054212982.1  DNA-binding protein Ikaros isoform X5

      UniProtKB/TrEMBL
      A0A8V8TNQ0

    40. XM_054357003.1 → XP_054212978.1  DNA-binding protein Ikaros isoform X3

    41. XM_054357042.1 → XP_054213017.1  DNA-binding protein Ikaros isoform X30

    42. XM_054357031.1 → XP_054213006.1  DNA-binding protein Ikaros isoform X22

    43. XM_054357032.1 → XP_054213007.1  DNA-binding protein Ikaros isoform X22

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001220766.1: Suppressed sequence

      Description
      NM_001220766.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

    2. NM_001220769.1: Suppressed sequence

      Description
      NM_001220769.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

    3. NM_001220772.1: Suppressed sequence

      Description
      NM_001220772.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    4. NM_001220773.1: Suppressed sequence

      Description
      NM_001220773.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    5. NM_001220774.1: Suppressed sequence

      Description
      NM_001220774.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    6. NM_001220775.1: Suppressed sequence

      Description
      NM_001220775.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    7. NM_001220776.1: Suppressed sequence

      Description
      NM_001220776.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13422.1 GenPept UniProtKB/Swiss-Prot:Q13422

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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