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    LACTB2 lactamase beta 2 [ Homo sapiens (human) ]

    Gene ID: 51110, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LACTB2provided by HGNC
    Official Full Name
    lactamase beta 2provided by HGNC
    Primary source
    HGNC:HGNC:18512
    See related
    Ensembl:ENSG00000147592 MIM:618921; AllianceGenome:HGNC:18512
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-83
    Summary
    Enables RNA endonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 25.7), kidney (RPKM 23.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LACTB2 in Genome Data Viewer
    Location:
    8q13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (70637266..70669185, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (71067173..71099092, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (71549501..71581420, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375890 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:71453867-71454367 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27508 Neighboring gene LACTB2 antisense RNA 1 Neighboring gene translocation associated membrane protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27510 Neighboring gene RNA, 7SL, cytoplasmic 19, pseudogene Neighboring gene XK related 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:71660008-71660508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27511 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:71716960-71717817 Neighboring gene uncharacterized LOC124901960 Neighboring gene NANOG hESC enhancer GRCh37_chr8:71971312-71971813 Neighboring gene uncharacterized LOC124901959

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease. Levy S, et al. Nucleic Acids Res, 2016 Feb 29. PMID 26826708, Free PMC Article
    2. Genome wide association study identifies two loci associated with cadmium in erythrocytes among never-smokers. Borné Y, et al. Hum Mol Genet, 2016 Jun 1. PMID 27005419
    3. LACTB2 renders radioresistance by activating PINK1/Parkin-dependent mitophagy in nasopharyngeal carcinoma. Chen Q, et al. Cancer Lett, 2021 Oct 10. PMID 34271102
    4. Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal cancer. Yu J, et al. Oncogene, 2016 Jan 14. PMID 25823027, Free PMC Article
    5. Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-interacting proteins. Zheng YX, et al. Acta Biochim Biophys Sin (Shanghai), 2021 Aug 31. PMID 34159380

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LACTB2 renders radioresistance by activating PINK1/Parkin-dependent mitophagy in nasopharyngeal carcinoma.
      Title: LACTB2 renders radioresistance by activating PINK1/Parkin-dependent mitophagy in nasopharyngeal carcinoma.
    2. This genome-wide study of never smokers from the general population identified two independent regions related to erythrocyte cadmium. The strongest locus covers the XKR9 and LACTB2 genes, which both could have related functions in cadmium absorption and metabolism
      Title: Genome wide association study identifies two loci associated with cadmium in erythrocytes among never-smokers.
    3. this study discovered that LACTB2 is an endoribonuclease that is involved in the turnover of mitochondrial RNA, and is essential for mitochondrial function in human cells.
      Title: Identification of LACTB2, a metallo-β-lactamase protein, as a human mitochondrial endoribonuclease.
    4. Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal cancer
      Title: Disruption of NCOA2 by recurrent fusion with LACTB2 in colorectal cancer.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HTP PubMed 

    General protein information

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    Preferred Names
    endoribonuclease LACTB2
    Names
    beta-lactamase-like protein 2
    testicular secretory protein Li 23
    NP_057111.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016027.3 → NP_057111.1  endoribonuclease LACTB2

      See identical proteins and their annotated locations for NP_057111.1

      Status: VALIDATED

      Source sequence(s)
      AC022731, AF151841, DB445101
      Consensus CDS
      CCDS6208.1
      UniProtKB/Swiss-Prot
      A8K2D6, Q53H82, Q9Y392
      UniProtKB/TrEMBL
      A0A024R811
      Related
      ENSP00000276590.4, ENST00000276590.5
      Conserved Domains (1) summary
      cd07722
      Location:14 → 203
      LACTB2-like_MBL-fold; uncharacterized subgroup which includes human lactamase beta 2 and related proteins; MBL-fold metallo hydrolase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      70637266..70669185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      71067173..71099092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53H82.2 GenPept UniProtKB/Swiss-Prot:Q53H82

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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