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    GTSE1 G2 and S-phase expressed 1 [ Homo sapiens (human) ]

    Gene ID: 51512, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GTSE1provided by HGNC
    Official Full Name
    G2 and S-phase expressed 1provided by HGNC
    Primary source
    HGNC:HGNC:13698
    See related
    Ensembl:ENSG00000075218 MIM:607477; AllianceGenome:HGNC:13698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B99
    Summary
    The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 2.8), lymph node (RPKM 2.7) and 15 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GTSE1 in Genome Data Viewer
    Location:
    22q13.31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (46296870..46330810)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (46781567..46815510)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (46692767..46726707)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13908 Neighboring gene tetratricopeptide repeat domain 38 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19234 Neighboring gene GTSE1 divergent transcript Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:46718535-46719734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:46731701-46732200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46757719-46758220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46758221-46758720 Neighboring gene tRNA mitochondrial 2-thiouridylase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19236 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:46772879-46774078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46777489-46777988 Neighboring gene cadherin EGF LAG seven-pass G-type receptor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:46780176-46780359 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:46782038-46783237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:46787203-46788025 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46805763-46806264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19238 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:46838653-46839604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46849165-46849747 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:46849748-46850331 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:46851429-46851929 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:46858535-46859734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46867173-46867992 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:46868263-46868432 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46875081-46875610 Neighboring gene family with sequence similarity 136 member A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells. Subhash VV, et al. BMC Cancer, 2015 Jul 25. PMID 26209226, Free PMC Article
    2. GTSE1: A potential prognostic and diagnostic biomarker in various tumors including lung adenocarcinoma. Yan G, et al. Clin Respir J, 2024 May. PMID 38715380, Free PMC Article
    3. GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration. Scolz M, et al. PLoS One, 2012. PMID 23236459, Free PMC Article
    4. Silencing GTSE-1 expression inhibits proliferation and invasion of hepatocellular carcinoma cells. Guo L, et al. Cell Biol Toxicol, 2016 Aug. PMID 27240802, Free PMC Article
    5. Up-regulation of GTSE1 lacks a relationship with clinical data in lung cancer. Tian T, et al. Asian Pac J Cancer Prev, 2011. PMID 22292647

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GTSE1: A potential prognostic and diagnostic biomarker in various tumors including lung adenocarcinoma.
      Title: GTSE1: A potential prognostic and diagnostic biomarker in various tumors including lung adenocarcinoma.
    2. GTSE1 is possibly involved in the DNA damage repair and cisplatin resistance in osteosarcoma.
      Title: GTSE1 is possibly involved in the DNA damage repair and cisplatin resistance in osteosarcoma.
    3. Destabilization of Long Astral Microtubules via Cdk1-Dependent Removal of GTSE1 from Their Plus Ends Facilitates Prometaphase Spindle Orientation.
      Title: Destabilization of Long Astral Microtubules via Cdk1-Dependent Removal of GTSE1 from Their Plus Ends Facilitates Prometaphase Spindle Orientation.
    4. GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling.
      Title: GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling.
    5. Downregulation of GTSE1 leads to the inhibition of proliferation, migration, and Warburg effect in cervical cancer by blocking LHDA expression.
      Title: Downregulation of GTSE1 leads to the inhibition of proliferation, migration, and Warburg effect in cervical cancer by blocking LHDA expression.
    6. MiR-509-3-5p inhibits colon cancer malignancy by suppressing GTSE1.
      Title: MiR-509-3-5p inhibits colon cancer malignancy by suppressing GTSE1.
    7. GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
      Title: GTSE1 promotes SNAIL1 degradation by facilitating its nuclear export in hepatocellular carcin oma cells.
    8. G2 and S phase-expressed-1 acts as a putative tumor promoter in cervical cancer by enhancing Wnt/beta-catenin signaling via modulation of GSK-3beta.
      Title: G2 and S phase-expressed-1 acts as a putative tumor promoter in cervical cancer by enhancing Wnt/β-catenin signaling via modulation of GSK-3β.
    9. GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway.
      Title: GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway.
    10. GTSE1, together with CDC20, PCNA, and MCM6, may synergistically promote adverse prognosis in hepatocellular carcinoma by activating cell cycle.
      Title: GTSE1, CDC20, PCNA, and MCM6 Synergistically Affect Regulations in Cell Cycle and Indicate Poor Prognosis in Liver Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule-based process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    G2 and S phase-expressed protein 1
    Names
    G-2 and S-phase expressed 1
    Lnc_bc060912
    protein B99 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016426.7 → NP_057510.5  G2 and S phase-expressed protein 1

      Status: REVIEWED

      Source sequence(s)
      AL031588, Z93024
      Consensus CDS
      CCDS14074.2
      UniProtKB/Swiss-Prot
      B0QYM3, Q20WK2, Q53GX5, Q5R3I6, Q6DHX4, Q9BRE0, Q9NYZ3, Q9UGZ9, Q9Y557
      UniProtKB/TrEMBL
      B4DZT6
      Related
      ENSP00000415430.1, ENST00000454366.2
      Conserved Domains (2) summary
      pfam15259
      Location:28 → 171
      GTSE1_N; G-2 and S-phase expressed 1
      cl26464
      Location:169 → 662
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      46296870..46330810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441391.1 → XP_047297347.1  G2 and S phase-expressed protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B0QYM3, Q20WK2, Q53GX5, Q5R3I6, Q6DHX4, Q9BRE0, Q9NYZ3, Q9UGZ9, Q9Y557
      UniProtKB/TrEMBL
      B4DZT6

    2. XM_047441392.1 → XP_047297348.1  G2 and S phase-expressed protein 1 isoform X2

    RNA

    1. XR_007067974.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      46781567..46815510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325674.1 → XP_054181649.1  G2 and S phase-expressed protein 1 isoform X2

    RNA

    1. XR_008485399.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NYZ3.4 GenPept UniProtKB/Swiss-Prot:Q9NYZ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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