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    TNFRSF1B TNF receptor superfamily member 1B [ Homo sapiens (human) ]

    Gene ID: 7133, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TNFRSF1Bprovided by HGNC
    Official Full Name
    TNF receptor superfamily member 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:11917
    See related
    Ensembl:ENSG00000028137 MIM:191191; AllianceGenome:HGNC:11917
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II
    Summary
    The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 31.9), spleen (RPKM 25.2) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TNFRSF1B in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (12166991..12209220)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (11711114..11753352)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12227048..12269277)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12138073-12139071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 200 Neighboring gene RNA, U6 small nuclear 777, pseudogene Neighboring gene ribosomal protein L23a pseudogene 89 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 206 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12220881-12221390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12221391-12221900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12221901-12222410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 284 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 285 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12227474-12228115 Neighboring gene Sharpr-MPRA regulatory region 6671 Neighboring gene uncharacterized LOC124903844 Neighboring gene microRNA 7846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:12238957-12239924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:12248891-12249428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:12251775-12252326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12261613-12262147 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12262148-12262681 Neighboring gene microRNA 4632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:12267047-12267547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 286 Neighboring gene uncharacterized LOC124900427 Neighboring gene ribosomal protein L10 pseudogene 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Serum level of soluble tumor necrosis factor receptor 2 is associated with the outcome of patients with diffuse large B-cell lymphoma treated with the R-CHOP regimen. Nakamura N, et al. Eur J Haematol, 2013 Oct. PMID 23672298
    2. Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis. Morita C, et al. Arthritis Rheum, 2001 Dec. PMID 11762942
    3. Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology. Putko BN, et al. PLoS One, 2014. PMID 24923671, Free PMC Article
    4. Synergism between circulating tumor necrosis factor receptor 2 and HbA(1c) in determining renal decline during 5-18 years of follow-up in patients with type 1 diabetes and proteinuria. Skupien J, et al. Diabetes Care, 2014 Sep. PMID 24898299, Free PMC Article
    5. Circulating TNF receptor 2 is closely associated with the kidney function in non-diabetic Japanese subjects. Kurashina T, et al. J Atheroscler Thromb, 2014. PMID 24717758

    See all (545) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tumor necrosis factor receptor 2 promotes endothelial cell-mediated suppression of CD8+ T cells through tuning glycolysis in chemoresistance of breast cancer.
      Title: Tumor necrosis factor receptor 2 promotes endothelial cell-mediated suppression of CD8+ T cells through tuning glycolysis in chemoresistance of breast cancer.
    2. TNFR2 pathways are fully active in cancer regulatory T cells.
      Title: TNFR2 pathways are fully active in cancer regulatory T cells.
    3. Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation.
      Title: Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation.
    4. Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients.
      Title: Association of polymorphisms in the TNFA, TNFRSF1A and TNFRSF1B genes with lepromatous leprosy in Western Mexican patients.
    5. Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients.
      Title: Circulating TNF-RII, IP-10 and HGF are associated with severity of COVID-19 in oncologic patients.
    6. Progesterone modulates TNF receptors expression by Jurkat cells cultured with plasma from pregnant women with preeclampsia.
      Title: Progesterone modulates TNF receptors expression by Jurkat cells cultured with plasma from pregnant women with preeclampsia.
    7. TNFRSF1B Gene Variants in Clinicopathological Aspects and Prognosis of Patients with Cutaneous Melanoma.
      Title: TNFRSF1B Gene Variants in Clinicopathological Aspects and Prognosis of Patients with Cutaneous Melanoma.
    8. Tregs from human blood differentiate into nonlymphoid tissue-resident effector cells upon TNFR2 costimulation.
      Title: Tregs from human blood differentiate into nonlymphoid tissue-resident effector cells upon TNFR2 costimulation.
    9. Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion.
      Title: Microglial TNFR2 signaling regulates the inflammatory response after CNS injury in a sex-specific fashion.
    10. Knockouts of TNFRSF1A and TNFRSF1B Genes in K562 Cell Line Lead to Diverse Long-Lasting Responses to TNF-alpha.
      Title: Knockouts of TNFRSF1A and TNFRSF1B Genes in K562 Cell Line Lead to Diverse Long-Lasting Responses to TNF-α.
    Submit: New GeneRIF Correction See all GeneRIFs (374)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV/tuberculosis coinfection upregulates TNFRSF1B expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with tuberculosis only) PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Apoptosis of CD8+ cells is mediated by the interaction between TNF-alpha bound to the membrane of macrophages (mbTNF) and a receptor on CD8+ T cells (TNF-receptor II, or TNFRII), which is upregulated by treatment with recombinant HIV-1 gp120 or SDF-1 PubMed
    env HIV-1 gp120 upregulates mu opioid receptor (MOR) expression in TPA-differentiated HL-60 cells; treatment with TNF-alpha neutralizing antibody as well as anti-TNF-alpha receptor type II (TNFR-II) antibody, inhibits gp120-induced upregulation of MOR PubMed
    Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B, CD120b) PubMed
    Tat tat HIV-1 Tat downregulates the cell surface expression of the p80 form of the tumor necrosis factor receptor (TNFR2) PubMed
    Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B, CD120b) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tumor necrosis factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tumor necrosis factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tumor necrosis factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA destabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aortic valve development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glial cell-neuron signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cardiac muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of extracellular matrix constituent secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neuroinflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of apoptotic process involved in morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of membrane protein ectodomain proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of oligodendrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of oligodendrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pulmonary valve development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of T cell cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of T cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cytokine production involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of tumor necrosis factor receptor superfamily complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in varicosity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 1B
    Names
    TNF-R2
    TNF-RII
    p75 TNF receptor
    p80 TNF-alpha receptor
    tumor necrosis factor beta receptor
    tumor necrosis factor binding protein 2
    tumor necrosis factor receptor 2
    tumor necrosis factor receptor type II

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029791.1 RefSeqGene

      Range
      4989..47218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001066.3 → NP_001057.1  tumor necrosis factor receptor superfamily member 1B precursor

      See identical proteins and their annotated locations for NP_001057.1

      Status: REVIEWED

      Source sequence(s)
      AL031276, AL357835
      Consensus CDS
      CCDS145.1
      UniProtKB/Swiss-Prot
      B1AJZ3, P20333, Q16042, Q6YI29, Q9UIH1
      UniProtKB/TrEMBL
      Q8IVS6
      Related
      ENSP00000365435.3, ENST00000376259.7
      Conserved Domains (1) summary
      cd10577
      Location:40 → 201
      TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      12166991..12209220
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542060.3 → XP_011540362.1  tumor necrosis factor receptor superfamily member 1B isoform X1

      UniProtKB/TrEMBL
      Q8IVS6
      Conserved Domains (1) summary
      cd10577
      Location:40 → 201
      TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2

    2. XM_047429422.1 → XP_047285378.1  tumor necrosis factor receptor superfamily member 1B isoform X2

      UniProtKB/TrEMBL
      Q8IVS6

    3. XM_011542063.3 → XP_011540365.1  tumor necrosis factor receptor superfamily member 1B isoform X4

      UniProtKB/TrEMBL
      Q8IVS6
      Conserved Domains (1) summary
      cd10577
      Location:40 → 201
      TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2

    4. XM_047429424.1 → XP_047285380.1  tumor necrosis factor receptor superfamily member 1B isoform X5

      UniProtKB/TrEMBL
      Q8IVS6

    5. XM_047429423.1 → XP_047285379.1  tumor necrosis factor receptor superfamily member 1B isoform X3

      UniProtKB/TrEMBL
      Q8IVS6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      11711114..11753352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338566.1 → XP_054194541.1  tumor necrosis factor receptor superfamily member 1B isoform X1

      UniProtKB/TrEMBL
      Q8IVS6

    2. XM_054338567.1 → XP_054194542.1  tumor necrosis factor receptor superfamily member 1B isoform X2

      UniProtKB/TrEMBL
      Q8IVS6

    3. XM_054338569.1 → XP_054194544.1  tumor necrosis factor receptor superfamily member 1B isoform X4

      UniProtKB/TrEMBL
      Q8IVS6

    4. XM_054338568.1 → XP_054194543.1  tumor necrosis factor receptor superfamily member 1B isoform X3

      UniProtKB/TrEMBL
      Q8IVS6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20333.3 GenPept UniProtKB/Swiss-Prot:P20333

    Gene LinkOut

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