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    GGT7 gamma-glutamyltransferase 7 [ Homo sapiens (human) ]

    Gene ID: 2686, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GGT7provided by HGNC
    Official Full Name
    gamma-glutamyltransferase 7provided by HGNC
    Primary source
    HGNC:HGNC:4259
    See related
    Ensembl:ENSG00000131067 MIM:612342; AllianceGenome:HGNC:4259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GGT4; GGTL3; GGTL5; D20S101
    Summary
    This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 10.3), thyroid (RPKM 7.4) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See GGT7 in Genome Data Viewer
    Location:
    20q11.22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (34844720..34872856, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (36565362..36593497, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33432523..33460659, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene nuclear receptor coactivator 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33384717-33385693 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33385694-33386669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12848 Neighboring gene high mobility group box 3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33450836-33451387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12849 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12851 Neighboring gene acyl-CoA synthetase short chain family member 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:33508643-33509842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17771 Neighboring gene glutathione synthetase Neighboring gene myosin heavy chain 7B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Activity determination, kinetic analyses and isoenzyme identification of gamma glutamyltransferase in human neutrophils. Sener A, et al. J Biochem Mol Biol, 2005 May 31. PMID 15943911
    2. Gamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy. Wang X, et al. Oncogene, 2022 Jun. PMID 35662282
    3. [The role of polymorphic variants rs11546155 and rs6119534 of the GGT7 gene and risk factors in the development of acute pancreatitis]. Samgina TA, et al. Vopr Pitan, 2022. PMID 35596634
    4. γ-Glutamyl transferase 7 is a novel regulator of glioblastoma growth. Bui TT, et al. BMC Cancer, 2015 Apr 7. PMID 25884624, Free PMC Article
    5. A genome-wide association study identifies novel association between genetic variants in GGT7 and LINC00944 and hypertension. Tan C, et al. Clin Transl Med, 2021 May. PMID 34047475, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy.
      Title: Gamma-glutamyltransferase 7 suppresses gastric cancer by cooperating with RAB7 to induce mitophagy.
    2. [The role of polymorphic variants rs11546155 and rs6119534 of the GGT7 gene and risk factors in the development of acute pancreatitis].
      Title: [The role of polymorphic variants rs11546155 and rs6119534 of the GGT7 gene and risk factors in the development of acute pancreatitis].
    3. A genome-wide association study identifies novel association between genetic variants in GGT7 and LINC00944 and hypertension.
      Title: A genome-wide association study identifies novel association between genetic variants in GGT7 and LINC00944 and hypertension.
    4. Our study demonstrates that GGT7 is a novel player in GBM growth and that GGT7 can play a critical role in tumorigenesis by regulating anti-oxidative damage.
      Title: γ-Glutamyl transferase 7 is a novel regulator of glioblastoma growth.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. GGTL3 protein interacts with CT120, a plasma membrane-associated protein possibly involved in lung carcinogenesis.
      Title: Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • dJ18C9.2

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene C4 gamma-glutamyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene D4 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione hydrolase 7
    Names
    GGT 7
    gamma-glutamyltransferase 4
    gamma-glutamyltransferase-like 3
    gamma-glutamyltransferase-like 5
    gamma-glutamyltranspeptidase 7
    gamma-glutamyltranspeptidase-like 3
    NP_001338631.1
    NP_821158.2
    XP_011527084.1
    XP_011527085.1
    XP_016883300.1
    XP_047296063.1
    XP_047296064.1
    XP_047296065.1
    XP_047296066.1
    XP_047296067.1
    XP_054179331.1
    XP_054179332.1
    XP_054179333.1
    XP_054179334.1
    XP_054179335.1
    XP_054179336.1
    XP_054179337.1
    XP_054179338.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351702.2 → NP_001338631.1  glutathione hydrolase 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice in the 3' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) has a novel C-terminus and is shorter than isoform 1
      Source sequence(s)
      AL049709
      UniProtKB/TrEMBL
      A4FU32
      Conserved Domains (1) summary
      pfam01019
      Location:155 → 607
      G_glu_transpept; Gamma-glutamyltranspeptidase

    2. NM_178026.3 → NP_821158.2  glutathione hydrolase 7 isoform 1

      See identical proteins and their annotated locations for NP_821158.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL049709, BC033745, BX401449, DA117929
      Consensus CDS
      CCDS13242.2
      UniProtKB/Swiss-Prot
      Q8N899, Q8NF66, Q9BYP5, Q9BYP6, Q9UJ14
      UniProtKB/TrEMBL
      A5D8W8
      Related
      ENSP00000338964.5, ENST00000336431.10
      Conserved Domains (1) summary
      pfam01019
      Location:155 → 654
      G_glu_transpept; Gamma-glutamyltranspeptidase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      34844720..34872856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440107.1 → XP_047296063.1  glutathione hydrolase 7 isoform X1

      UniProtKB/TrEMBL
      A5D8W8

    2. XM_011528782.3 → XP_011527084.1  glutathione hydrolase 7 isoform X7

      Conserved Domains (1) summary
      cl19223
      Location:1 → 420
      G_glu_transpept; Gamma-glutamyltranspeptidase

    3. XM_047440111.1 → XP_047296067.1  glutathione hydrolase 7 isoform X6

    4. XM_011528783.4 → XP_011527085.1  glutathione hydrolase 7 isoform X8

      Conserved Domains (1) summary
      cl19223
      Location:1 → 371
      G_glu_transpept; Gamma-glutamyltranspeptidase

    5. XM_047440110.1 → XP_047296066.1  glutathione hydrolase 7 isoform X4

      UniProtKB/TrEMBL
      A0PJJ9

    6. XM_047440109.1 → XP_047296065.1  glutathione hydrolase 7 isoform X3

      UniProtKB/TrEMBL
      A0PJJ9

    7. XM_047440108.1 → XP_047296064.1  glutathione hydrolase 7 isoform X2

      UniProtKB/TrEMBL
      A0PJJ9

    8. XM_017027811.2 → XP_016883300.1  glutathione hydrolase 7 isoform X5

      UniProtKB/TrEMBL
      A0PJJ9
      Conserved Domains (1) summary
      cl19223
      Location:155 → 528
      G_glu_transpept; Gamma-glutamyltranspeptidase

    RNA

    1. XR_001754240.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      36565362..36593497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323356.1 → XP_054179331.1  glutathione hydrolase 7 isoform X1

      UniProtKB/TrEMBL
      A5D8W8

    2. XM_054323362.1 → XP_054179337.1  glutathione hydrolase 7 isoform X7

    3. XM_054323361.1 → XP_054179336.1  glutathione hydrolase 7 isoform X6

    4. XM_054323363.1 → XP_054179338.1  glutathione hydrolase 7 isoform X8

    5. XM_054323359.1 → XP_054179334.1  glutathione hydrolase 7 isoform X4

      UniProtKB/TrEMBL
      A0PJJ9

    6. XM_054323358.1 → XP_054179333.1  glutathione hydrolase 7 isoform X3

      UniProtKB/TrEMBL
      A0PJJ9

    7. XM_054323357.1 → XP_054179332.1  glutathione hydrolase 7 isoform X2

      UniProtKB/TrEMBL
      A0PJJ9

    8. XM_054323360.1 → XP_054179335.1  glutathione hydrolase 7 isoform X5

      UniProtKB/TrEMBL
      A0PJJ9

    RNA

    1. XR_008485251.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178025.1: Suppressed sequence

      Description
      NM_178025.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UJ14.2 GenPept UniProtKB/Swiss-Prot:Q9UJ14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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