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    MCEMP1 mast cell expressed membrane protein 1 [ Homo sapiens (human) ]

    Gene ID: 199675, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MCEMP1provided by HGNC
    Official Full Name
    mast cell expressed membrane protein 1provided by HGNC
    Primary source
    HGNC:HGNC:27291
    See related
    Ensembl:ENSG00000183019 MIM:609565; AllianceGenome:HGNC:27291
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C19orf59
    Summary
    This gene encodes a single-pass transmembrane protein. Based on its expression pattern, it is speculated to be involved in regulating mast cell differentiation or immune responses. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in lung (RPKM 39.7), bone marrow (RPKM 28.1) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See MCEMP1 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7677090..7679829)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7677976..7680714)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7741976..7744715)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RPS27A pseudogene 19 Neighboring gene resistin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9990 Neighboring gene Sharpr-MPRA regulatory region 435 Neighboring gene trafficking protein particle complex subunit 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:7749795-7749977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13895 Neighboring gene Fc epsilon receptor II Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13897

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Mast-cell expressed membrane protein-1 is expressed in classical monocytes and alveolar macrophages in idiopathic pulmonary fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ-dependent manner. Perrot CY, et al. Am J Physiol Cell Physiol, 2024 Mar 1. PMID 38189137, Free PMC Article
    2. Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis. Raman K, et al. Stroke, 2016 Mar. PMID 26846866
    3. Identification and expression of a new type II transmembrane protein in human mast cells. Li K, et al. Genomics, 2005 Jul. PMID 15953541
    4. Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. Denner J, et al. PLoS One, 2013. PMID 23383108, Free PMC Article
    5. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mast-cell expressed membrane protein-1 is expressed in classical monocytes and alveolar macrophages in idiopathic pulmonary fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFbeta-dependent manner.
      Title: Mast-cell expressed membrane protein-1 is expressed in classical monocytes and alveolar macrophages in idiopathic pulmonary fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ-dependent manner.
    2. The expression of the gene MCEMP1 had the strongest association with stroke of 11,181 genes tested.
      Title: Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke Prognosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of chromosome 19 open reading frame 59 (C19orf59; MCEMP1) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC132456

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    mast cell-expressed membrane protein 1
    Names
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174918.3 → NP_777578.3  mast cell-expressed membrane protein 1

      Status: REVIEWED

      Source sequence(s)
      AC008763
      Consensus CDS
      CCDS12183.2
      UniProtKB/Swiss-Prot
      Q8IX19, Q8IX20
      UniProtKB/TrEMBL
      A0A384NYE9
      Related
      ENSP00000329920.3, ENST00000333598.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      7677090..7679829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      7677976..7680714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IX19.1 GenPept UniProtKB/Swiss-Prot:Q8IX19

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