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    SSH2 slingshot protein phosphatase 2 [ Homo sapiens (human) ]

    Gene ID: 85464, updated on 3-Dec-2024

    Summary

    Official Symbol
    SSH2provided by HGNC
    Official Full Name
    slingshot protein phosphatase 2provided by HGNC
    Primary source
    HGNC:HGNC:30580
    See related
    Ensembl:ENSG00000141298 MIM:606779; AllianceGenome:HGNC:30580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SSH-2; SSH-2L
    Summary
    This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Broad expression in lymph node (RPKM 6.2), appendix (RPKM 6.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SSH2 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (29625938..29930228, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (30568840..30873583, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27952956..28257246, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27940429-27941292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27942158-27943021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8384 Neighboring gene Sharpr-MPRA regulatory region 12866 Neighboring gene ankyrin repeat domain 13B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8385 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:27950531-27951730 Neighboring gene NANOG hESC enhancer GRCh37_chr17:27960948-27961512 Neighboring gene Sharpr-MPRA regulatory region 11433 Neighboring gene uncharacterized LOC107984990 Neighboring gene Sharpr-MPRA regulatory region 3347 Neighboring gene RNA, U6 small nuclear 920, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7669 Neighboring gene coronin 6 Neighboring gene VISTA enhancer hs1675 Neighboring gene MPRA-validated peak2783 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:28040137-28040766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8386 Neighboring gene ribosomal protein L21 pseudogene 123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8387 Neighboring gene RNA terminal phosphate cyclase like 1 pseudogene Neighboring gene uncharacterized LOC124900394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11987 Neighboring gene uncharacterized LOC124900390 Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein L9 pseudogene 30 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8388 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8391 Neighboring gene Sharpr-MPRA regulatory region 3195 Neighboring gene EF-hand calcium binding domain 5 Neighboring gene Sharpr-MPRA regulatory region 15362 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:28367348-28368547 Neighboring gene RNY4 pseudogene 13 Neighboring gene syntaxin 18 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1725, MGC78588

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein phosphatase Slingshot homolog 2
    Names
    SSH-like protein 2
    NP_001269058.1
    NP_001269059.1
    NP_001269060.1
    NP_203747.2
    XP_005258115.1
    XP_005258116.1
    XP_005258117.1
    XP_006722212.1
    XP_011523706.1
    XP_011523709.1
    XP_016880742.1
    XP_047292923.1
    XP_047292924.1
    XP_047292925.1
    XP_047292926.1
    XP_047292927.1
    XP_054173595.1
    XP_054173596.1
    XP_054173597.1
    XP_054173598.1
    XP_054173599.1
    XP_054173600.1
    XP_054173601.1
    XP_054173602.1
    XP_054173603.1
    XP_054173604.1
    XP_054173605.1
    XP_054173606.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282129.2NP_001269058.1  protein phosphatase Slingshot homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_001269058.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB099290, AC104982, AI609950, AK296413, DA749059
      Consensus CDS
      CCDS74024.1
      UniProtKB/TrEMBL
      B4DK64, F5H527
      Related
      ENSP00000444743.1, ENST00000540801.6
      Conserved Domains (3) summary
      cd11652
      Location:38263
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:335470
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:278329
      DEK_C; DEK C terminal domain
    2. NM_001282130.2NP_001269059.1  protein phosphatase Slingshot homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001269059.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks multiple coding exons and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC104564, AC104982, BC008941, DA749059
      UniProtKB/Swiss-Prot
      Q76I76
      Conserved Domains (1) summary
      cd11652
      Location:3178
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    3. NM_001282131.2NP_001269060.1  protein phosphatase Slingshot homolog 2 isoform 4

      See identical proteins and their annotated locations for NP_001269060.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains multiple differences in the UTRs and coding region, compared to variant 1, including the lack of multiple 5' and 3' coding exons. It represents use of an internal promoter and initiates translation at an alternate start codon. The encoded isoform (4) is shorter and has distinct N- and C- termini, compared to isoform 1.
      Source sequence(s)
      AC104564, BC008941, BC011636, DA861985
      Consensus CDS
      CCDS92286.1
      UniProtKB/TrEMBL
      A0A3B3ITS1
      Related
      ENSP00000497894.1, ENST00000324677.12
      Conserved Domains (1) summary
      cd11652
      Location:37185
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    4. NM_033389.3NP_203747.2  protein phosphatase Slingshot homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_203747.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB099290, AC104564, AI609950, DA749059
      Consensus CDS
      CCDS11253.1
      UniProtKB/Swiss-Prot
      Q76I76, Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8
      UniProtKB/TrEMBL
      B4DK64
      Related
      ENSP00000269033.3, ENST00000269033.7
      Conserved Domains (3) summary
      cd11652
      Location:3236
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:308443
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:251302
      DEK_C; DEK C terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      29625938..29930228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436967.1XP_047292923.1  protein phosphatase Slingshot homolog 2 isoform X3

      UniProtKB/Swiss-Prot
      Q76I76, Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8
      UniProtKB/TrEMBL
      B4DK64
    2. XM_005258058.4XP_005258115.1  protein phosphatase Slingshot homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_005258115.1

      UniProtKB/TrEMBL
      B4DK64, F5H527
      Conserved Domains (3) summary
      cd11652
      Location:38263
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:335470
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:278329
      DEK_C; DEK C terminal domain
    3. XM_047436968.1XP_047292924.1  protein phosphatase Slingshot homolog 2 isoform X11

      UniProtKB/TrEMBL
      A0A3B3IS79
    4. XM_011525407.1XP_011523709.1  protein phosphatase Slingshot homolog 2 isoform X6

      See identical proteins and their annotated locations for XP_011523709.1

      UniProtKB/TrEMBL
      A0A3B3IS79
      Conserved Domains (3) summary
      cd11652
      Location:17160
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:232367
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:175226
      DEK_C; DEK C terminal domain
    5. XM_005258059.3XP_005258116.1  protein phosphatase Slingshot homolog 2 isoform X2

      See identical proteins and their annotated locations for XP_005258116.1

      UniProtKB/TrEMBL
      A0A3B3IS79
      Related
      ENSP00000497148.1, ENST00000649863.1
      Conserved Domains (3) summary
      cd11652
      Location:37243
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:315450
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:258309
      DEK_C; DEK C terminal domain
    6. XM_047436969.1XP_047292925.1  protein phosphatase Slingshot homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A3B3IS79
    7. XM_006722149.5XP_006722212.1  protein phosphatase Slingshot homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A3B3IS79
      Conserved Domains (3) summary
      cd11652
      Location:14214
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:286421
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:229280
      DEK_C; DEK C terminal domain
    8. XM_011525404.3XP_011523706.1  protein phosphatase Slingshot homolog 2 isoform X4

      UniProtKB/TrEMBL
      A0A3B3IS79
      Conserved Domains (3) summary
      cd11652
      Location:18218
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:290425
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:233284
      DEK_C; DEK C terminal domain
    9. XM_005258060.4XP_005258117.1  protein phosphatase Slingshot homolog 2 isoform X7

      UniProtKB/TrEMBL
      B3KRE8
    10. XM_047436970.1XP_047292926.1  protein phosphatase Slingshot homolog 2 isoform X9

    11. XM_017025253.3XP_016880742.1  protein phosphatase Slingshot homolog 2 isoform X8

    12. XM_047436971.1XP_047292927.1  protein phosphatase Slingshot homolog 2 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      30568840..30873583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317622.1XP_054173597.1  protein phosphatase Slingshot homolog 2 isoform X3

      UniProtKB/TrEMBL
      B4DK64
    2. XM_054317620.1XP_054173595.1  protein phosphatase Slingshot homolog 2 isoform X1

      UniProtKB/TrEMBL
      B4DK64
    3. XM_054317627.1XP_054173602.1  protein phosphatase Slingshot homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A3B3IS79
    4. XM_054317626.1XP_054173601.1  protein phosphatase Slingshot homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A3B3IS79
    5. XM_054317625.1XP_054173600.1  protein phosphatase Slingshot homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A3B3IS79
    6. XM_054317621.1XP_054173596.1  protein phosphatase Slingshot homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IS79
    7. XM_054317624.1XP_054173599.1  protein phosphatase Slingshot homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A3B3IS79
    8. XM_054317623.1XP_054173598.1  protein phosphatase Slingshot homolog 2 isoform X4

      UniProtKB/TrEMBL
      A0A3B3IS79
    9. XM_054317628.1XP_054173603.1  protein phosphatase Slingshot homolog 2 isoform X7

      UniProtKB/TrEMBL
      B3KRE8
    10. XM_054317630.1XP_054173605.1  protein phosphatase Slingshot homolog 2 isoform X9

    11. XM_054317629.1XP_054173604.1  protein phosphatase Slingshot homolog 2 isoform X8

    12. XM_054317631.1XP_054173606.1  protein phosphatase Slingshot homolog 2 isoform X10